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Search Results for "Fingolimod Hplc Method"

23:20 EDT 19th April 2014 | BioPortfolio

Original Source: Simultaneous identification and validated quantification of 11 oral hypoglycaemic drugs in plasma by electrospray ionisation liquid chromatography-mass spectrometry.

The detection of diabetic metabolism disorders raises problems in forensic practice and sudden death with a subsequent negative autopsy finding is a common problem. In the case of an unclear hypoglycaemia, the detection of oral antidiabetics allows the differentiation of hypoglycaemia due to oral antidiabetics from that due to other reasons (insulin-induced, insulinoma). The development of an electrospray ionisation (ESI) liquid chromatography-tandem mass spectrometry (LC-MS/MS) procedure for the simultaneo...

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DNA-FISH Probes

Fluorescent in situ hybridization (FISH) is a sensitive and accurate technique that allows the detection of chromosome aberrations. In this method, a single-stranded fluorescent-labeled nucleic acid...

Spirometry Test

The gold standard in lung testing In the same way that blood pressure measurements provide a simple yet effective screening method for cardiovascular disease, spirometry tests can help to unmask t...

Drug Delivery - news, views, blogs

Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals.  Drug delivery technologies are patent protected formulat...

Herpes simplex virus HSV 1 HSV 2 HHV 1 HHV 2

Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as Human herpes virus 1 and 2 (HHV-1 and -2), are two members of the herpes virus family that infect humans. HSV-1 and HSV-2 cause the vira...

Testicular Cancer

Testicular cancer represents only 1 per cent of all cancers in men, but it is the single biggest cause of cancer-related deaths in men aged 15-35 years in the UK. The causes of testicular cancer and...

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HPLC/UHPLC Method Development

Shimadzu Scientific Instruments has introduced the Nexera Method Scouting System. Capable of automatically investigating up to 96 combinations of mobile phases, gradients and columns, it improves HPLC...

Shimadzu's New Nexera Method Scouting System Maximizes Efficiency In HPLC/UHPLC Method Development

Shimadzu Scientific Instruments (SSI) has introduced the Nexera Method Scouting System. Capable of automatically investigating up to 96 combinations of mobile phases, gradients and columns, it signifi...

[Comment] Effects of fingolimod in relapsing-remitting multiple sclerosis

Fingolimod, a sphingosine-1-phosphate receptor modulator, was the first oral drug to be approved for treatment of relapsing-remitting multiple sclerosis. Its approval was based on findings from the pl...

HPLC Determination of Target Explosive Compounds in Water

Thermo Fisher Scientific has developed an on-line solid phase extraction (SPE)high-performance liquid chromatography (HPLC) with ultraviolet absorbance detection method to determine the 14 explosives...

HPLC Columns

JM Science offers a complete line of Shiseido HPLC CAPCELL PAK columnsRead more about HPLC Columns

HPLC Determination of Carbendazim in Orange Juice

Thermo Fisher Scientific has developed a reproducible and accurate high-performance liquid chromatography (HPLC) method combined with on-line solid-phase extraction for the sensitive determination of...

[Articles] Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial

Our findings expand knowledge of the safety profile of fingolimod and strengthen evidence for its beneficial effects on relapse rates in patients with relapsing-remitting multiple sclerosis. We saw no...

Determination of Related Substances in Pemetrexed Disodium (Form-IV) in Bulk Drug Samples by HPLC

The authors describe the development of a stability-indicating reverse-phase high-performance liquid chromatographic (RP?HPLC) method for the quantitative determination of potential genotoxic impu...

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Paroxysmal atrial fibrillation after initiation of fingolimod for multiple sclerosis treatment.

Fingolimod (FTY720, Gilenya, Novartis Pharma AG, Basel, Switzerland) is an oral disease-modifying therapy (DMT), approved for relapsing multiple sclerosis (MS), which acts via modulation of the sphing...

Sensitive and rapid determination of elemental nanosulfur/sulfur by liquid chromatography.

In order to identify the most suitable method for the estimation of nanosulfur for studying its residue dynamics, the present work was taken up. HPLC and GC methods were explored for its analysis. A c...

Successful treatment of fingolimod-associated macular edema with intravitreal triamcinolone with continued fingolimod use.

The occurrence of macular edema as an adverse effect of fingolimod is well documented. Treatment modalities used to manage fingolimod-associated macular edema (FAME) have included nonsteroidal anti-in...

Comparison of four different methods for the determination of sulfites in foods marketed in South Korea.

Sulfites in foods were analysed using four methods: optimised Monier-Williams (official method), modified Rankine, HPLC and ion-exchange chromatography (IEC). The modified Rankine and HPLC methods wer...

Development and Optimisation of an HPLC-DAD-ESI-Q-ToF Method for the Determination of Phenolic Acids and Derivatives.

A method for the HPLC-MS/MS analysis of phenols, including phenolic acids and naphtoquinones, using an amide-embedded phase column was developed and compared to the literature methods based on classic...

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