Search Results for "Fingolimod Hplc Method"

11:58 EDT 1st August 2014 | BioPortfolio

Original Source: Simultaneous identification and validated quantification of 11 oral hypoglycaemic drugs in plasma by electrospray ionisation liquid chromatography-mass spectrometry.

The detection of diabetic metabolism disorders raises problems in forensic practice and sudden death with a subsequent negative autopsy finding is a common problem. In the case of an unclear hypoglycaemia, the detection of oral antidiabetics allows the differentiation of hypoglycaemia due to oral antidiabetics from that due to other reasons (insulin-induced, insulinoma). The development of an electrospray ionisation (ESI) liquid chromatography-tandem mass spectrometry (LC-MS/MS) procedure for the simultaneo...

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DNA-FISH Probes

Fluorescent in situ hybridization (FISH) is a sensitive and accurate technique that allows the detection of chromosome aberrations. In this method, a single-stranded fluorescent-labeled nucleic acid...

Spirometry Test

The gold standard in lung testing In the same way that blood pressure measurements provide a simple yet effective screening method for cardiovascular disease, spirometry tests can help to unmask t...

Drug Delivery - news, views, blogs

Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals.  Drug delivery technologies are patent protected formulat...

Herpes simplex virus HSV 1 HSV 2 HHV 1 HHV 2

Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as Human herpes virus 1 and 2 (HHV-1 and -2), are two members of the herpes virus family that infect humans. HSV-1 and HSV-2 cause the vira...

Testicular Cancer

Testicular cancer represents only 1 per cent of all cancers in men, but it is the single biggest cause of cancer-related deaths in men aged 15-35 years in the UK. The causes of testicular cancer and...

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HPLC/UHPLC Method Development

Shimadzu Scientific Instruments has introduced the Nexera Method Scouting System. Capable of automatically investigating up to 96 combinations of mobile phases, gradients and columns, it improves HPLC...

Shimadzu's New Nexera Method Scouting System Maximizes Efficiency In HPLC/UHPLC Method Development

Shimadzu Scientific Instruments (SSI) has introduced the Nexera Method Scouting System. Capable of automatically investigating up to 96 combinations of mobile phases, gradients and columns, it signifi...

[Comment] Effects of fingolimod in relapsing-remitting multiple sclerosis

Fingolimod, a sphingosine-1-phosphate receptor modulator, was the first oral drug to be approved for treatment of relapsing-remitting multiple sclerosis. Its approval was based on findings from the pl...

Ultra-high Speed HPLC Analysis of USP Methods within the New USP General Chapter 621 Allowed Limits

This paper examines the key parameters of allowed HPLC adjustments in the current and revised USP general chapter 621. It then demonstrates the successful transfer to an ultra-high-speed method, r...

Simultaneous Determination of Amlodipine and Its Counterion Besylate

Thermo Fisher Scientific has developed a simple, rapid, reliable, and accurate high-performance liquid chromatography (HPLC) method for the simultaneous determination of amlodipine and besyl...

Determination of Related Substances in Pemetrexed Disodium (Form-IV) in Bulk Drug Samples by HPLC

The authors describe the development of a stability-indicating reverse-phase high-performance liquid chromatographic (RP?HPLC) method for the quantitative determination of potential genotoxic impu...

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

Fingolimod is a sphingosine-1 phosphate (S1P) receptor modulator and an immune modulator in use as a treatment for the remitting-relapsing form of multiple sclerosis. Hait et al. show that the active...

[Articles] Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial

Our findings expand knowledge of the safety profile of fingolimod and strengthen evidence for its beneficial effects on relapse rates in patients with relapsing-remitting multiple sclerosis. We saw no...

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Paroxysmal atrial fibrillation after initiation of fingolimod for multiple sclerosis treatment.

Fingolimod (FTY720, Gilenya, Novartis Pharma AG, Basel, Switzerland) is an oral disease-modifying therapy (DMT), approved for relapsing multiple sclerosis (MS), which acts via modulation of the sphing...

Sensitive and rapid determination of elemental nanosulfur/sulfur by liquid chromatography.

In order to identify the most suitable method for the estimation of nanosulfur for studying its residue dynamics, the present work was taken up. HPLC and GC methods were explored for its analysis. A c...

Fingolimod in a patient with heart failure on the background of pulmonary arterial hypertension and coronary artery disease.

Fingolimod is the first oral immunomodulatory therapy approved for highly active relapsing remitting multiple sclerosis. Based on the distribution pattern of fingolimod interacting sphingosine-1-phosp...

Successful treatment of fingolimod-associated macular edema with intravitreal triamcinolone with continued fingolimod use.

The occurrence of macular edema as an adverse effect of fingolimod is well documented. Treatment modalities used to manage fingolimod-associated macular edema (FAME) have included nonsteroidal anti-in...

Comparing major alkaloids of Fritillariae Hupehensis Bulbs (FHB) and congeneric plants by HPLC-ELSD and HPLC-ESI-MS(n.)

In the study, the major alkaloids from Fritillariae Hupehensis Bulbs (FHB) have been analysed for the first time by the combined use of the following two methods: the simultaneous quantitation of thre...

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