Search Results for "Fingolimod Hplc Method"

02:04 EDT 1st November 2014 | BioPortfolio

Original Source: Simultaneous identification and validated quantification of 11 oral hypoglycaemic drugs in plasma by electrospray ionisation liquid chromatography-mass spectrometry.

The detection of diabetic metabolism disorders raises problems in forensic practice and sudden death with a subsequent negative autopsy finding is a common problem. In the case of an unclear hypoglycaemia, the detection of oral antidiabetics allows the differentiation of hypoglycaemia due to oral antidiabetics from that due to other reasons (insulin-induced, insulinoma). The development of an electrospray ionisation (ESI) liquid chromatography-tandem mass spectrometry (LC-MS/MS) procedure for the simultaneo...

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DNA-FISH Probes

Fluorescent in situ hybridization (FISH) is a sensitive and accurate technique that allows the detection of chromosome aberrations. In this method, a single-stranded fluorescent-labeled nucleic acid...

Spirometry Test

The gold standard in lung testing In the same way that blood pressure measurements provide a simple yet effective screening method for cardiovascular disease, spirometry tests can help to unmask t...

Drug Delivery - news, views, blogs

Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals.  Drug delivery technologies are patent protected formulat...

Herpes simplex virus HSV 1 HSV 2 HHV 1 HHV 2

Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as Human herpes virus 1 and 2 (HHV-1 and -2), are two members of the herpes virus family that infect humans. HSV-1 and HSV-2 cause the vira...

Testicular Cancer

Testicular cancer represents only 1 per cent of all cancers in men, but it is the single biggest cause of cancer-related deaths in men aged 15-35 years in the UK. The causes of testicular cancer and...

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Universal solution for automated HPLC method development

Universal solution for automated HPLC method development Shimadzu?s Nexera Method Scouting system provides an outstanding platform for efficient HPLC method development and implementation. It is b...

Shimadzu

Universal solution for automated HPLC method development Shimadzu?s Nexera Method Scouting system provides an outstanding platform for efficient HPLC method development and implementation. It is b...

Ultra-high Speed HPLC Analysis of USP Methods within the New USP General Chapter 621 Allowed Limits

This paper examines the key parameters of allowed HPLC adjustments in the current and revised USP general chapter 621. It then demonstrates the successful transfer to an ultra-high-speed method, r...

Simultaneous Determination of Amlodipine and Its Counterion Besylate

Thermo Fisher Scientific has developed a simple, rapid, reliable, and accurate high-performance liquid chromatography (HPLC) method for the simultaneous determination of amlodipine and besyl...

Fingolimod for chronic inflammatory demyelinating polyneuropathy – second line

Fingolimod is intended to be used as second line therapy for the treatment of patients with chronic inflammatory demyelinating polyneuropathy (CIDP). If licensed, fingolimod would offer an additional ...

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

Fingolimod is a sphingosine-1 phosphate (S1P) receptor modulator and an immune modulator in use as a treatment for the remitting-relapsing form of multiple sclerosis. Hait et al. show that the active ...

Can HPLC assay methods really be considered quality critical tests?

Analytical method specificity is assessed using ICH (International Conference on Harmonisation) Q2 (2005). Although, certain methods are not specific enough for their intended purposes, they may have ...

Switching From MS Injectables to Fingolimod

Dr. Andrew Wilner speaks with lead author Bruce Cree about a study that examined patient satisfaction and clinician perceptions after a switch from injectable MS drugs to fingolimod. Medscape Neurol...

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Paroxysmal atrial fibrillation after initiation of fingolimod for multiple sclerosis treatment.

Fingolimod (FTY720, Gilenya, Novartis Pharma AG, Basel, Switzerland) is an oral disease-modifying therapy (DMT), approved for relapsing multiple sclerosis (MS), which acts via modulation of the sphing...

Sensitive and rapid determination of elemental nanosulfur/sulfur by liquid chromatography.

In order to identify the most suitable method for the estimation of nanosulfur for studying its residue dynamics, the present work was taken up. HPLC and GC methods were explored for its analysis. A c...

Fingolimod in a patient with heart failure on the background of pulmonary arterial hypertension and coronary artery disease.

Fingolimod is the first oral immunomodulatory therapy approved for highly active relapsing remitting multiple sclerosis. Based on the distribution pattern of fingolimod interacting sphingosine-1-phosp...

Successful treatment of fingolimod-associated macular edema with intravitreal triamcinolone with continued fingolimod use.

The occurrence of macular edema as an adverse effect of fingolimod is well documented. Treatment modalities used to manage fingolimod-associated macular edema (FAME) have included nonsteroidal anti-in...

Experience with Fingolimod in Clinical Practice.

Aim: To report experience with fingolimod in clinical practice. Design/Methods: Patients in an academic medical center who were prescribed fingolimod from October 2010 to August 2011 were identified t...

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