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Low-dose flutamide doesn't eliminate hepatotoxicity risk

NEW YORK (Reuters Health) - Low or ultralow doses of flutamide don't entirely eliminate the drug's potential for injuring the liver, researchers saw in a study of women with polycystic ovary syndr...

Pharmaceutical Research: Micellar Delivery of Flutamide Via Milk Protein Nanovehicles Enhances its Anti-Tumor Efficacy in Androgen-Dependent Prostate Cancer Rat Model

Type: Original PaperPurposeThis article describes the preparation, physicochemical characterization and in vivo assessment of parenteral colloidal formulation of flutamide (FLT) based on biocompatible...

PCF Funding Contributed to the Development and Approval of Xtandi

Xtandi, formerly known as MDV3100, today received approval from the U.S. Food and Drug Administration (FDA). This drug is a new-generation anti-androgen treatment that can prolong...

Involvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injury.

Drug-induced liver injury is a growing concern for pharmaceutical companies and patients because numerous drugs have been linked to hepatotoxicity and it is the most common reason for a drug to be wit...

The Expression of FSH Receptor (FSHR) in the Neonatal Porcine Ovary and its Regulation by Flutamide.

Contents This study was designed to reveal the FSHR mRNA and protein expression in the neonatal porcine ovary and to determine whether maternal administration of antiandrogen flutamide may affect FSHR...

Effect of methanol extract of Basella alba L. (Basellaceae) on the fecundity and testosterone level in male rats exposed to flutamide in utero.

We evaluated the effect of the methanol extract of Basella alba (MEBa) on testosterone level and fecundity/fertility in male rats exposed in utero to flutamide - an androgen receptor antagonist. For t...

Flutamide, an androgen receptor antagonist, improves heatstroke outcomes in mice.

Flutamide has been used as an adjunct for decreasing the mortality from subsequent sepsis. Heatstroke resembles septic shock in many aspects. We hypothesized that heat-induced multiple organ dysfuncti...

Administration of Flutamide Alters Sperm Ultrastructure, Sperm Plasma Membrane Integrity and its Stability, and Sperm Mitochondrial Oxidative Capability in the Boar: In Vivo and In Vitro Approach.

Our previous work has shown that an anti-androgen flutamide administered pre- and post-natally induced adverse effects on the epididymal morphology and function of adult boars. The present investigati...