Metabotropic Glutamate Receptor 4 (mGluR4)

Metabotropic glutamate receptor 4 is a protein that in humans is encoded by the GRM4 gene. Together with GRM6, GRM7 and GRM8 it belongs to group III of the metabotropic glutamate receptor famil...

Parathyroid Hormone PTH Receptor

There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins. * parathy...

Interleukin 6 IL 6 Receptor IL 6R

Although the causes of rheumatoid arthritis are not fully understood, constitutive overproduction of interleukin-6 (IL-6), a multifunctional cytokine that regulates immune response, inflammatory react...

HER2 receptor Mab rDNA

Interleukin IL-6 receptor Mab rDNA

Evidence for the existence of dopamine d2-oxytocin receptor heteromers in the ventral and dorsal striatum with facilitatory receptor–receptor interactions

Leiden researchers achieve highest resolution ever for human protein

Receptor The protein in question is the adenosine A2A receptor, the main receptor for caffeine in the human body. This receptor is also linked to Parkinson's disease. The class of around 800 protei...

Comparison of prognostic values between combined immunohistochemical score of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67 and the corresponding gene expression score in breast cancer

Where have all the active receptor states gone?

Defining G protein–coupled receptor ligand efficacy and biased agonism in precise chemical terms is one challenge posed by the current structural data that exists for this receptor family. Concepts...

Breast Cancers Can Change Biologically as They Progress and Relapse

In many women with recurrent breast cancer, the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status of their tumors changes between treatment...

Therapies for ALL and AML targeting MER receptor hold promise of more effect with less side-effect

(University of Colorado Denver) Two University of Colorado Cancer Center studies show that the protein receptor Mer is overexpressed in many leukemias, and that inhibition of this Mer receptor results...

T Cell Receptor Signaling Pathway in Oncology Drug Pipeline Update 2013

Extra value: One year of free online updates included with this product Stimulation of the T cell receptor leads to the activation of NFkB and NFAT signaling modules which play a key role in T cell re...

Adenosine A1 and Dopamine D1 Receptor Regulation of AMPA Receptor Phosphorylation and Cocaine-Seeking Behavior

Regulation of survival and chemoresistance by HSP90AA1 in ovarian cancer SKOV3 cells.

Previous researches have showed that HSP90AA is important in ovarian cancer, but the mechanism of HSP90AA is still unknown. This study aimed to investigate the role of the potential therapy target pro...

Effect of tamoxifen, methoxyprogesterone acetate and combined treatment on cellular proliferation and apoptosis in SKOV3/DDP cells via the regulation of vascular endothelial growth factor.

PURPOSE: The aim of this study was to investigate the effect of tamoxifen (TAM), methoxyprogesterone acetate (MPA) and their combined treatment on cisplatin-resistant ovarian cancer SKOV3/DDP cells, a...

miR-449b and miR-34c on inducing down-regulation of cell cycle-related proteins and cycle arrests in SKOV3-ipl cell, an ovarian cancer cell line.

OBJECTIVE:To investigate the effects of miR-449 and miR-34 on cell growth, cell cycle and target gene expression based on these miRNA different expressions in ovarian cancer cell lines SKOV3 and SKOV3...

Up-regulation of mitochondrial antioxidation signals in ovarian cancer cells with aggressive biologic behavior.

Objective: Recently, a high frequency of mutations in mitochondrial DNA (mtDNA) has been detected in ovarian cancer. To explore the alterations of proteins in mitochondria in ovarian cancer, a pair of...

MUC4 mucin-induced epithelial to mesenchymal transition: a novel mechanism for metastasis of human ovarian cancer cells.

The acquisition of invasiveness in ovarian cancer (OC) is accompanied by the process of epithelial-to-mesenchymal transition (EMT). The MUC4 mucin is overexpressed in ovarian tumors and has a role in...