Search Results for "Folate Receptor Alpha"
Original Source: Farletuzumab, a Humanized Monoclonal Antibody against Folate Receptor Alpha, in Epithelial Ovarian Cancer: A Phase I Study.
PURPOSE: Folate receptor alpha (FRα) expression is highly restricted in normal adult tissues, but upregulated in a wide range of human cancer types including epithelial ovarian cancer (EOC). Farletuzumab, a humanized monoclonal antibody against FRα, has demonstrated anti-tumor activity and favorable toxicity in preclinical evaluation. This phase I dose-escalation study was conducted to determine the safety of weekly intravenous farletuzumab and establish the maximum tolerated dose (MTD).EXPERIMENTAL DESIG...
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Interleukin 1 IL 1 Receptor IL 1R
Interleukin-1 (IL-1) beta is a proinflammatory cytokine driving joint inflammation as well as systemic signs of inflammation, such as fever and acute phase protein production. Current therapy targetin...
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Engineered T cells kill tumors but spare normal tissue in an animal model
(University of Pennsylvania School of Medicine) Researchers devised a next gen cancer immune approach in which the activation signal for T cells is physically dissociated from a second costimulatory s...
Eisai's farletuzumab misses endpoint in first Phase III ovarian cancer data
The first topline Phase III data for Eisai's next big oncology hope farletuzumab (MORAb-003) show that the folate receptor-alpha (FRA)-targeting antibody missed its progression-free survival (PFS) pri...
Genes Dictate Folate Benefit in Schizophrenia (CME/CE)
(MedPage Today) -- Patients with schizophrenia saw symptom improvement with folate supplements, but response was predicted by variants in genes that regulate the folate metabolism, a randomized clinic...
ImmunoCellular obtains US patent covering use of interleukin 13-receptor alpha 2 protein
ImmunoCellular Therapeutics has obtained US patent for methods of use of interleukin 13-receptor alpha 2 protein (IL-13Rα2) in cancer immunotherapy.
Type: Original PaperThe purpose of this study was to investigate the in vivo distribution and antitumor activity of irinotecan (camptothecin (CPT)-11)-loaded folate-targeted liposome (F-Lip) in tumor-...
- Results Show 72 Percent of Adenocarcinomas and 51 Percent of Squamous Cell Carcinoma of the Lung Express Folate Receptor - - Data Published in Archives of Pathology & Laboratory Medicine -...
No evidence of cancer risk from folate supplements
Lancet2013; doi:10.1016/S0140-6736(12)62001-7bmj;346/jan30_1/f546/FIG1F1fig1Concerns about links between folate supplements and some types of cancer led researchers to reanalyse the individual...
EMA accepts vintafolide, etarfolatide MAAs
Endocyte Inc. (NASDAQ:ECYT) and partner Merck & Co. Inc. (NYSE:MRK) said EMA accepted for review MAAs for conditional approval of vintafolide and companion diagnostic etarfolatide to treat folate rece...
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A Low Molecular Weight Folate Receptor Targeted Contrast Agent for Magnetic Resonance Tumor Imaging.
PURPOSE: This study aims to develop a low molecular weight folate receptor (FR) contrast agent for MR tumor imaging. PROCEDURES: Gadolinium-tetraazacyclododecane tetraacetic acid (Gd.DOTA) was conjuga...
Design and synthesis of (99m)Tc-citro-folate for use as a tumor-targeted radiopharmaceutical.
Folate conjugates exhibit high affinity for folate receptor (FR) positive cells and tissues, such as those in tumors, making them attractive candidates and of interest in diagnostic tumor imaging. The...
Targeting tumor cells through chitosan-folate modified microcapsules loaded with camptothecin.
Poly-vinyl alcohol microcapsules have been tailored as carriers to deliver camptothecin, an anticancer drug poorly soluble in water. The capsules have been reacted with a chitosan-folate complex in or...
Folate supplementation differently affects uracil content in DNA in the mouse colon and liver.
High folate intake may increase the risk of cancer, especially in the elderly. The present study examined the effects of ageing and dietary folate on uracil misincorporation into DNA, which has a muta...
The effect of chemotherapy on expression of folate receptor-alpha in ovarian cancer.
BACKGROUND: Folate receptor alpha (FR-α) has been identified as a potential target in ovarian cancer for diagnostic and therapeutic purposes, based on its overexpression in serous epithelial ovarian...
