Duocarmycin analogs

Antibody-drug conjugates are designed to combine the specificity of antibodies directed against tumor-associated targets with potent cytotoxity. Upon internalization of the ADC, the antibody-bound c...

Parathyroid Hormone PTH Receptor

There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins. * parathy...

Improving FRET dynamic range with bright green and red fluorescent proteins

Development of the bright green and red fluorescent proteins, Clover and mRuby2, creates a fluorescence resonance energy transfer (FRET) pair with the highest Förster radius among existing ratiometri...

Whitepaper: Discriminant Analysis of Raw Materials Using Near-Infrared Spectroscopy

NIRS is an analytical technique based on absorption measured in the near-infrared region of the electromagnetic spectrum that is between the visible and the mid-infrared regions...

New device hides, on cue, from infrared cameras

Cambridge, Mass. - November 26, 2012 - Now you see it, now you don't. A new device invented at the Harvard School of Engineering and Applied Sciences (SEAS) can absorb 99.75% of infrared light tha...

Near-Infrared Spectroscopy Systems

An alliance between Metrohm and FOSS brings expands Metrohm’s traditional focus on wet chemistry applications to include Near-Infrared (NIR)analyzers for the pharmaceutical, chemical, petrochemical,...

Infrared vision in a cichlid fish

(University of Bonn) Biologists from the University of Bonn have discovered that the cichlid fish Pelvicachromis taeniatus can see in the near infrared range; this was thought to be unlikely until now...

Infrared signaling could create sense of touch in artificial limbs

Rats can't usually see infrared light, but they have "touched" it in a Duke University lab. The rats sensed the light as a sensation of touch after Duke neurobiologist Miguel Nicolelis and his team fi...

Damping pathways of mid-infrared plasmons in graphene nanostructures

Researchers clarify damping pathways for mid-infrared graphene plasmons, including graphene intrinsic optical phonons and edge scattering. They also demonstrate the guiding of mid-infrared graphene pl...

Infrared Spectral Histopathology for Lung Cancer Classification

A new technology based on infrared hyperspectral data is proving invaluable for classification of common forms of lung cancers. Laboratory Investigation

Turn-on and near-infrared fluorescent sensing for 2,4,6-trinitrotoluene based on hybrid (gold nanorod)-(quantum dots) assembly.

In this study, we design a FRET system consisting of gold nanorod (AuNR) and quantum dots (QDs) for turn-on fluorescent sensing of 2,4,6-trinitrotoluene (TNT) in near-infrared region. The amine-termin...

Fluorescent proteins for FRET microscopy: Monitoring protein interactions in living cells.

The discovery and engineering of novel fluorescent proteins (FPs) from diverse organisms is yielding fluorophores with exceptional characteristics for live-cell imaging. In particular, the development...

FRET spectral unmixing: a ratiometric fluorescent nanoprobe for hypochlorite.

A specific ratiometric nanoprobe for hypochlorite was constructed as a paradigm of FRET spectral unmixing. The separation of FRET pairs' emissions reaches 175 nm, which ensures that the FRET probing i...

Advances in Quantitative FRET-Based Methods for Studying Nucleic Acids.

Förster resonance energy transfer (FRET) is a powerful tool for monitoring molecular distances and interactions at the nanoscale level. The strong dependence of transfer efficiency on probe separatio...

Monitoring multiple distances within a single molecule using switchable FRET.

The analysis of structure and dynamics of biomolecules is important for understanding their function. Toward this aim, we introduce a method called 'switchable FRET', which combines single-molecule fl...