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Topical Vaccination with Functionalized Particles Targeting Dendritic Cells

A review of RGD-functionalized nonviral gene delivery vectors for cancer therapy

Pharmaceutical Research: Microfluidic Synthesis of PEG- and Folate-Conjugated Liposomes for One-Step Formation of Targeted Stealth Nanocarriers

Type: Original PaperPurposeA microfluidic hydrodynamic flow focusing technique enabling the formation of small and nearly monodisperse liposomes is investigated for continuous-flow synthesis of poly(e...

Pharmaceutical Research: Phosphatidylinositol 3-kinase Inhibitor (PIK75) Containing Surface Functionalized Nanoemulsion for Enhanced Drug Delivery, Cytotoxicity and Pro-apoptotic Activity in Ovarian Cancer Cells

Type: Original PaperPurposeOvarian cancer is a debilitating disease, which needs multi-pronged approach of targeted drug delivery and enhanced efficacy with the use of combination therapeutics. In thi...

Pharmaceutical Research: Engineered Andrographolide Nanoparticles Mitigate Paracetamol Hepatotoxicity in Mice

Type: Original PaperPurposeParacetamol (acetaminophen, APAP) overdose is often fatal due to progressive and irreversible hepatic necrosis. The aim of this work was to design Andrographolide (AG) loade...

Pharmaceutical Research: Functionalized Calcium Carbonate as a Novel Pharmaceutical Excipient for the Preparation of Orally Dispersible Tablets

Type: Original PaperPurposeTo overcome the limitation of insufficient hardness during the production of rapidly disintegrating orally dispersible tablets (ODTs). Furthermore, we investigated the prope...

Individual protein complex generates electric current

An team of scientists, led by Joachim Reichert, Johannes Barth, and Alexander Holleitner (Technische Universitaet Muenchen, Clusters of Excellence MAP and NIM), and Itai Carmeli (Tel Aviv University)...

Researchers ID chemical in cigarette smoke linked to lowered levels of 'good' cholesterol

(Medical Xpress)—Cigarette smoking's association with heart disease has been known for decades, but researchers are still not certain what chemicals or molecular processes in the body form the basis...

Further Insight into the Photostability of the Pyrene Fluorophore in Halogenated Solvents.

Pyrene fluorophores of pyrene-functionalized CdSe quantum dots (QD@Py), as well as alkylpyrene and pyrene itself (Py), undergo fast degradation in aerated chloroform under ultraviolet-A (UV-A, 316

Single-Walled Carbon Nanotubes Noncovalently Functionalized by Ruthenium(II) Complex Tagged with Pyrene: Electrochemical and Electrogenerated Chemiluminescence Properties.

Ru being served: A pyrene-Ru/SWCNT nanohybrid was formed through noncovalent π-π stacking interactions. After oxidative treatment, the pyrene-Ru/SWCNT-functionalized Pt electrode achieved a highly r...

High-Affinity DNA Targeting Using Readily Accessible Mimics of N2'-Functionalized 2'-Amino-α-L-LNA.

N2'-Pyrene-functionalized 2'-amino-α-L-LNAs (locked nucleic acids) display extraordinary affinity toward complementary DNA targets due to favorable preorganization of the pyrene moieties for hybridiz...

Pyrene-functionalized triazole-linked 2'-deoxyuridines-probes for discrimination of single nucleotide polymorphisms (SNPs).

Oligonucleotides modified with pyrene-functionalized triazole-linked 2'-deoxyuridines display remarkable hybridization-induced increases in fluorescence emission and enable efficient fluorescent discr...

Spectroscopic Characterization of i-motif Forming c-myc Derived Sequences Double-Labeled with Pyrene.

In current studies we use the oligonucleotides based on c-myc sequence: CCC CAC CCT CCC CAC CCT CCC C (cmyc22) and CCC CAC CCT CCC CAC CCT CCC CA (cmyc22A) functionalized by pyrene moieties at both te...