Gene Therapy

Gene Function

Motor system

Immune system

Reninangiotensinaldosterone system

Overexpression of miR-155 promotes growth of blood vessels in tumors and metastasis

Researchers at Moffitt Cancer Center have determined that the overexpression of microRNA-155 (miR-155), a short, single strand of ribonucleic acid encoded by the miR-155 host gene, promotes the growth...

Overexpression of Down syndrome cell adhesion molecule impairs precise synaptic targeting

In this study, the authors show that Dscam, a gene that has been implicated in Down syndrome, is targeted by the translation suppressor and Fragile X–linked protein FMRP. Loss of FMRP or overexpress...

Gene expression: RAC1 overexpression beats depression

KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer

Partial 17q gain resulting from isochromosomes, unbalanced translocations and complex rearrangements is associated with gene overexpression, older age and shorter overall survival in high hyperdiploid childhood acute lymphoblastic leukemia

Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b

Insulin resistance represents a hallmark during the development of type 2 diabetes mellitus and in the pathogenesis of obesity-associated disturbances of glucose and lipid metabolism. MicroRNA (miRNA)...

Chemotherapy Triggers Overexpression of a Drug Resistance Gene

Cancer researchers have identified a gene activated by chemotherapy and induce tumor cells to become drug resistant, which inevitably...

Overexpression of alpha-synuclein can cause Parkinson's

Researchers at the University of California, San Diego School of Medicine say overexpression of a protein called alpha-synuclein appears to disrupt vital recycling processes in neurons, starting with...

Lentivirus-mediated overexpression of TGF-β inducible early gene 1 inhibits SW1990 pancreatic cancer cell growth.

TGF-β inducible early gene 1 (TIEG1) plays a significant role in regulating cell proliferation and apoptosis in various cell types. Previous studies have shown a close relationship between the expres...

A study of HER2 gene amplification and protein expression in gastric cancer.

Background Gastric cancer is a leading cause of cancer-related mortality, and current treatment outcomes for advanced disease remain poor. HER2 has been identified as a potential candidate for targete...

A safe and effective plant gene switch system for tissue-specific induction of gene expression in Arabidopsis thaliana and Brassica juncea.

The ability to regulate spatial and temporal expression of genes is a useful tool in biotechnology as well as studies of functional genomics. Such regulation can provide information concerning the fun...

Homologous overexpression of omcZ, a gene for an outer surface c-type cytochrome of Geobacter sulfurreducens by single-step gene replacement.

The electron transfer pathway of Geobacter sulfurreducens has been intensively studied because of its ability of electron transfer to extracellular electron acceptors, such as Fe(III) and on electrode...

Effects of fatty acid activation on photosynthetic production of fatty acid-based biofuels in Synechocystis sp. PCC6803.

ABSTRACT: BACKGROUND: Direct conversion of solar energy and carbon dioxide to drop in fuel molecules in a single biological system can be achieved from fatty acid-based biofuels such as fatty alcohols...