Oral Administration

Oral treatment

Oral Contraceptives

Oral appliances

Oral antihyperglycemic drugs

Generex submits oral insulin Phase III trial dossier to Indian government

Canada’s Generex Biotechnology, through its Indian licensee Shreya Life Sciences, has submitted a dossier of recently concluded Phase III trial results of its oral insulin ‘Generex Oral-lyn’ to...

Generex Oral-lyn Phase III Dossier Submitted To Indian Government For Marketing Approval

Phase III Data Demonstrates Effectiveness and Non-inferiority When Compared to Injected Insulin WORCESTER, Mass. and TORONTO, Jan. 23, 2013 /PRNewswire/ -- Generex Biotechnology Corporation (www....

Generex Oral-lyn™ Phase III Dossier Submitted To Indian Government For Marketing Approval

WORCESTER, Mass. and TORONTO, Jan. 23, 2013 /PRNewswire/ -- Generex Biotechnology Corporation (www.generex.com) (OTCBB:GNBT) today announced that it has been advised by its Indian lice...

Buccal insulin may be back in India after Phase III results

Shreya Life Sciences, the Indian licensee of Generex Biotechnology Corporation, has submitted details of its recently completed Phase III trial of Generex Oral-lyn, the Canadian firm's buccal insulin...

AAPS PharmSciTech: Development of Amphotericin B-Loaded Cubosomes Through the SolEmuls Technology for Enhancing the Oral Bioavailability

Type: Original PaperThe oral administration of amphotericin B (AmB) has the major drawback of poor bioavailability. The aim of this work was to evaluate the potential of AmB-loaded cubosomes as an ora...

The AAPS Journal: Pharmacokinetics and Tissue Disposition of Lenalidomide in Mice

Type: Original PaperLenalidomide is a synthetic derivative of thalidomide exhibiting multiple immunomodulatory activities beneficial in the treatment of several hematological malignancies. Murine phar...

AAPS PharmSciTech: Improving Oral Bioavailability and Pharmacokinetics of Liposomal Metformin by Glycerolphosphate–Chitosan Microcomplexation

Type: Original PaperThe purpose of this study was to develop a new delivery system capable of improving bioavailability and controlling release of hydrophilic drugs. Metformin-loaded liposomes were pr...

AAPS PharmSciTech: Formulation and In Vivo Evaluation of Orally Disintegrating Tablets of Clozapine/Hydroxypropyl-β-cyclodextrin Inclusion Complexes

Type: Original PaperThe aim of this study was to improve the solubility and oral bioavailability of clozapine (CLZ), a poorly water-soluble drug subjected to substantial first-pass metabolism, employi...

Bioavailability of oral methylnaltrexone increases with a phosphatidylcholine-based formulation.

Abstract Objective: Methylnaltrexone (MNTX), a peripherally restricted opioid antagonist with mu-opioid receptor selectivity, can reduce opioid activity in the gastrointestinal tract while sparing the...

ADME Evaluation in Drug Discovery. 9. Prediction of Oral Bioavailability in Humans Based on Molecular Properties and Structural Fingerprints.

Oral bioavailability is an essential parameter in drug screening cascades and a good indicator of the capability of the delivery of a given compound to the systemic circulation by oral administration....

An Alternative Approach to Determine Oral Bioavailability of Drugs That Follow Michaelis-Menten Elimination: A Case Study with Vorizonazole.

Background/Aims: The determination of oral bioavailability of drugs which follow nonlinear pharmacokinetics is difficult and few methods are available. In this work, an alternative approach to determi...

P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel.

Paclitaxel is avidly transported by P-glycoprotein (P-gp/MDR1/ABCB1/rpar;. This results in low oral bioavailability, which can be boosted by co-administration of P-gp inhibitors. Unlike paclitaxel, do...

Formulation optimization and bioavailability after oral and nasal administration in rabbits of puerarin-loaded microemulsion.

The main objective of the study was to investigate the efficacy of microemulsion (ME) to facilitate bioavailability of puerarin (PUE) after oral and nasal administration. The pseudo-ternary phase diag...