Search Results for "Genetic Resistance To Cancer"
Original Source: Long-term hormonal promotion overcomes genetic resistance to mammary cancer.
It is well known that ovarian steroids estradiol and progesterone play a vital role in the development of mammary cancer. Here, using the genetically highly resistant Copenhagen rats we demonstrate that sustained exogenous treatment with estradiol and progesterone overcomes genetic resistance to mammary cancer. It has been demonstrated that Copenhagen rats develop preneoplastic lesions upon exposure to carcinogens. However, these preneoplastic lesions fail to progress to ductal carcinomas in situ or overt m...
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Antimicrobial resistance (AMR) is resistance of a microorganism to an antimicrobial medicine to which it was previously sensitive. Resistant organisms (they include bacteria, viruses and some parasi...
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Cancer Treatment Could Be Improved By Discovery Of Drug Resistance Biomarker
Cancer therapies often have short-lived benefits due to the emergence of genetic mutations that cause drug resistance. A key gene that determines resistance to a range of cancer drugs has been reporte...
Drug resistance biomarker could improve cancer treatment
(Cell Press) Cancer therapies often have short-lived benefits due to the emergence of genetic mutations that cause drug resistance. A key gene that determines resistance to a range of cancer drugs has...
TGF-betaR inhibitors may counter drug resistance in cancer patients with MED12 mutations
Cancer therapies often have short-lived benefits due to the emergence of genetic mutations that cause drug resistance. A key gene that determines resistance to a range of cancer drugs has been reporte...
Gene Loss May ID Resistance in Ovarian Cancer (CME/CE)
(MedPage Today) -- Acquired chemotherapy resistance in ovarian cancer had a significant association with genetic alterations involving a lipid transporter gene, Australian investigators reported.
Researchers find potential new genetic chemotherapy approach for cancer treatment
Researchers at The Jackson Laboratory have identified a molecule that prevents repair of some cancer cells, providing a potential new "genetic chemotherapy" approach to cancer treatment that could sig...
Genetic key to severe malaria resistance uncovered
Researchers have identified two genetic variants linked with human resistance to severe malaria.
Pre-Existing Mutations May Explain Development of Resistance to Targeted Cancer Drugs
Most patients with advanced colorectal cancer treated with the drug panitumumab (Vectibix) develop resistance to the treatment, and a new study suggests why. Even before patients begin the treatment,...
People with lung cancer who are treated with the drug Tarceva face a daunting uncertainty: although their tumors may initially shrink, it's not a question of whether their cancer will return - it's a...
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Carcinogenesis is an evolutionary process that establishes the 'hallmarks of cancer' by natural selection of cell clones that have acquired advantageous heritable characteristics. Evolutionary adaptat...
Targeted therapies: how personal should we go?
Despite the development of drugs inhibiting the oncogenic proteins that cancer cells are dependent on, attempts to match targeted therapies to the genetic makeup of individual tumors is proving more d...
ABSTRACT: BACKGROUND: Failure on Highly Active Anti-Retroviral Treatment is often accompanied with development of antiviral resistance to one or more drugs included in the treatment. In general, the v...
Tissue transglutaminase: a new target to reverse cancer drug resistance.
Cancer resistance mechanisms, which result from intrinsic genetic alterations of tumor cells or acquired genetic and epigenetic changes, limit the long-lasting benefits of anti-cancer treatments. Tiss...
ABSTRACT: BACKGROUND: The development of resistance to chemotherapies represents a significant barrier to successful cancer treatment. Resistance mechanisms are complex, can involve diverse and often...
