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05:16 EDT 2nd September 2014 | BioPortfolio

Original Source: Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways.

Normal, age-related depletion of the androgen testosterone is a risk factor for Alzheimer's disease (AD) in men. Previously, we reported that experimental androgen depletion significantly accelerates development of AD-like neuropathology in the 3xTg-AD triple-transgenic mouse model of AD, an effect prevented by androgen treatment. Because testosterone is metabolized in brain into both the androgen dihydrotestosterone (DHT) and the estrogen 17beta-estradiol (E2), testosterone can mediate its effects through ...

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Testosterone therapy

Hormones

Hormones are secreted by the endocrine system into the body and adjust the functioning of all organ systems in the body. Testosterone and Estrogen are male/female specific, while others such as adre...

Eligard

Eligard® is a hormone compound for the treatment of advanced, hormone-dependent prostate cancer. The active ingredient (leuprolide acetate) significantly reduces the level of the male sex hormon...

Bulimia Nervosa

Bulimia is an illness characterized by the cycle of binging on food, guilty feelings and resultant purging (vomiting or laxative abuse) to counteract the previous binge. It is much more common in yo...

Somatropin Hgh rDNA Pfizer

What is GENOTROPIN? GENOTROPIN (somatropin [rDNA origin] for injection) is a growth hormone treatment. It is an exact copy of the natural growth hormone that our bodies make. The main difference i...

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Trimel receives FDA approval for Natesto Nasal Gel male low testosterone

The FDA has approved Trimel Pharmaceuticals’ Natesto (testosterone), formerly CompleoTRT, a testosterone nasal gel for replacement therapy in adult males for conditions associated with a deficiency ...

FDA Approves Natesto (testosterone) Nasal Gel to Treat Men with Low Testosterone

TORONTO (May 28, 2014) – Trimel Pharmaceuticals Corporation (TSX: TRL) announced today that the United States Food and Drug Administration (FDA) has approved Natesto (testosterone), formerly Comple...

FDA approves Trimel's Natesto nasal gel to treat men with low testosterone

Canada-based Trimel Pharmaceuticals has received approval from the US Food and Drug Administration (FDA) for Natesto (testosterone) the first and only testosterone nasal gel for replacement therapy in...

Testosterone in healthy men increases their brains' response to threat

Testosterone, a steroid hormone, is well known to contribute to aggressive behavior in males, but the neural circuits through which testosterone exerts these effects have not been clear.

Aveed (testosterone undecanoate) for Treating Men with Hypogonadism

Aveed (testosterone undecanoate) is a testosterone replacement therapy indicated for the treatment of hypogonadism in adult men who are associated with a deficiency or absence of the male hormone test...

As Testosterone Lawsuits Are Filed In The U.S., Canada Warns of Possible Cardiac Risks Associated With Testosterone Medication

Columbus, OH (PRWEB) July 19, 2014 Wright & Schulte LLC has learned that Health Canada has issued a warning to patients and healthcare professionals of the potential life-threatening heart and ...

FDA approves Trimel’s Natesto nasal gel to treat adult males with low testosterone

Trimel Pharmaceuticals Corporation announced today that the United States Food and Drug Administration (FDA) has approved Natesto (testosterone), formerly CompleoTRT, the first and only testosterone n...

FDA committees to discuss testosterone therapies

FDA's Bone, Reproductive and Urologic Drugs and Drug Safety and Risk Management advisory committees will meet on Sept. 17 to discuss the appropriate indicated population and the potential for adverse ...

Matching PubMed Articles

Progressive Improvement of T-Scores in Men with Osteoporosis and Subnormal Serum Testosterone Levels upon Treatment with Testosterone over Six Years.

Testosterone deficiency leads to bone loss and testosterone treatment has a beneficial effect. This study investigated the effects of normalizing serum testosterone on bone mineral density in 45 men w...

Low testosterone levels, depressive symptoms, and falls in older men: a cross-sectional study.

While several studies have cited a potential association between testosterone deficiency and risk of falls among community-dwelling older men, evidence for such an association is conflicting. Depressi...

The Impact of Drug Reimbursement Policy on Rates of Testosterone Replacement Therapy among Older Men.

Despite a lack of data describing the long-term efficacy and safety of testosterone replacement therapy (TRT), prescribing of testosterone to older men has increased with the availability of topical f...

Testosterone Lab Testing and Initiation in the United Kingdom and the United States, 2000-2011.

Context: New formulations, increased marketing, and wider recognition of declining testosterone levels in older age may have contributed to wider testosterone testing and supplementation in many count...

Effect of testosterone on markers of mitochondrial oxidative phosphorylation and lipid metabolism in muscle of aging men with subnormal bioavailable testosterone.

Recent studies indicate that serum testosterone in aging men is associated with insulin sensitivity and expression of oxidative phosphorylation (OxPhos) genes, and that testosterone treatment increase...

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