Search Results for "Glial Development Growth Factor"
Original Source: Riluzole-induced glial cell line-derived neurotrophic factor production is regulated through fibroblast growth factor receptor signaling in rat C6 glioma cells.
Riluzole is approved for the treatment of amyotrophic lateral sclerosis (ALS); however, recent accumulating evidence suggests that riluzole is also effective for the treatment of psychiatric disorders, such as mood disorders. Plastic change in the brain induced by neurotrophic factors/growth factors is thought to be involved in the mechanism of antidepressants. This study investigated the mechanism of riluzole-induced glial cell line-derived neurotrophic factor (GDNF) production in rat C6 glioma cells (C6 c...
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The classical tissue factors typically are proteins used for tissue repair and growth stimulation. Among the approved products are the growth factors PDGF, IGF, EGF, BMP and FGF. One of the commercial...
Mesenchymal Epithelial Transition factor c MET
The c-MET signalling pathway consists of the mesenchymal epithelial transition factor (c-MET) transmembrane tyrosine kinase receptor and its ligand hepatocyte growth factor (HGF) or scatter factor (SF...
Keratinocyte growth factor rDNA
Transforming growth factor beta TGF beta
Transforming growth factor-beta (TGF-beta) family members are secreted multifunctional cytokines that play pivotal roles in development and disease. The prototypic member of this family, TGF-beta, pla...
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Glial cells assist in the repair of injured nerves
Unlike the brain and spinal cord, the peripheral nervous system has an astonishing capacity for regeneration following injury. Researchers at the Max Planck Institute of Experimental Medicine in Göt...
Unlike the brain and spinal cord, the peripheral nervous system has an astonishing capacity for regeneration following injury. Researchers at the Max Planck Institute of Experimental Medicine in Gotti...
MedGenesis wins grant to advance GDNF
MedGenesis Therapeutix, a biotechnology company, has received a grant from the Deutsche Parkinson Vereinigung e.V. for the Phase II development of glial cell line derived neurotrophic factor (GDNF).
Glial cell line-derived neurotrophic factor (GDNF) is a small human protein encoded by the GDNF gene. GDNF has been effective therapy in laboratory animal models of Parkinson's disease and protects se...
The digestive neuronal–glial–epithelial unit: a new actor in gut health and disease
The permeability of the intestinal epithelial barrier has a central role in the regulation of fluid and nutrient intake as well as in the control of the passage of pathogens. In this Review, Michel Ne...
Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy
During Wallerian degeneration of Drosophila axons, Draper and Crk/Mbc/dCed-12 signaling non-redundantly promote clearance of axonal debris. Draper signaling is required early to activate glial respons...
Acorda’s GGF2 can improve erectile function after cavernous nerve damage
Acorda Therapeutics, Inc. announced data from a preclinical study showed that treatment with Glial Growth Factor 2 (GGF2) improved erectile function in an animal model following a cavernous nerve (CN)...
Phase I for Acorda's new mechanism of action in heart failure justifies more studies
Phase I data are sufficient to justify another human clinical trial in the treatment of heart failure with Acorda Therapeutics' glial growth factor 2 (GGF2), which offers a new mechanism of action t...
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Growth factors stimulate expression of neuronal and glial miR-132.
Brain-specific microRNAs (miRs) and brain-derived neurotrophic factor (BDNF) are both involved in synaptic function. We previously reported that upregulation of miR-132 is involved in BDNF-increased s...
Background The enteric nervous system (ENS) continues its structural and functional growth after birth, with formation of ganglia and the innervation of growing smooth muscle. However, little is kn...
Spontaneous differentiation of porcine neural progenitors in vitro.
The pig is the non-primate species that is immunologically closest to humans, and has been considered as an alternative source to human allografts for transplantation. In fact, there has been recent i...
Development of a glial network in the olfactory nerve: role of calcium and neuronal activity.
In adult olfactory nerves of mammals and moths, a network of glial cells ensheathes small bundles of olfactory receptor axons. In the developing antennal nerve (AN) of the moth Manduca sexta, the axon...
