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Idenix raises $176 million

Idenix Pharmaceuticals Inc. (NASDAQ:IDIX) raised $176 million through the sale of 22 million shares at $8 in a bumped-up follow-on underwritten by JPMorgan; Leerink; BofA Merrill Lynch; and William Bl...

The prokaryote messenger c-di-GMP triggers stalk cell differentiation in Dictyostelium

Cyclic di-(3′:5′)-guanosine monophosphate (c-di-GMP) is a major prokaryote signalling intermediate that is synthesized by diguanylate cyclases and triggers sessility and biofilm formation. We dete...

Xyleme Releases 3.7 Update of Flagship Product, Xyleme LCMS

BOULDER, Colo., Sept. 19, 2012 (GLOBE NEWSWIRE) -- With the increase in use of technology for learning, learners are demanding to access their content on the many devices they are already using, when...

Codelivery of VEGF siRNA and Gemcitabine Monophosphate in a Single Nanoparticle Formulation for Effective Treatment of NSCLC

Cyclic adenosine monophosphate involvement in low-dose cyclophosphamide-reversed immune evasion in a mouse lymphoma model

Quantitative Analysis of Biomarkers, New Life Science Webinar Hosted by Xtalks

Xtalks presents an exciting live webinar on Friday June 27, 2013 at 11am EDT on the quantitative analysis of biomarkers with the specificity and robustness of liquid chromatography/mass spectrometry (...

Novartis, Idenix terminate option deal

Idenix Pharmaceuticals Inc. (NASDAQ:IDIX) and Novartis AG (SIX:NOVN; NYSE:NVS) terminated a 2003 deal that gave the pharma an option to in-license any of the biotech's compounds after a proof-of-conce...

Pall Introduces 13 mm Acrodisc® MS Syringe Filter Certified for Low LCMS Extractables in Small Samples

Pall Corporation (NYSE:PLL) has introduced a 13 mm Acrodisc® MS syringe filter certified for low extractables in high performance liquid chromatography/mass spectrometry (...

Inhibition of Guanosine Monophosphate Synthetase by the Substrate Enantiomer L-XMP.

Mirror, mirror…︁? The enantioselectivity of guanosine monophosphate synthetase (GMPS), a key enzyme in GMP biosynthesis, was characterized by using D- and L-xanthosine 5'-monophosphate (XMP) as su...

Gas-phase isolation of diethyl guanosine 5'-monophosphate and its conformational assignment.

We show that intact neutral molecules of guanosine 5'-monophosphate can be vaporized by laser desorption when its phosphate group is esterified. The UV and IR spectroscopic measurements of this nucleo...

Discovery of N(2)-(1-carboxyethyl)guanosine 5'-monophosphate as an umami-enhancing maillard-modified nucleotide in yeast extracts.

Sensory-guided fractionation of a commercial yeast extract involving medium-pressure RP-18 chromatography and ion-pair chromatography, followed by LC-MS/MS, LC-TOF-MS, 1D/2D-NMR, and CD spectroscopy,...

Modulation of guanosine nucleotides biosynthetic pathways enhanced GDP-L: -fucose production in recombinant Escherichia coli.

Guanosine 5'-triphosphate (GTP) is the key substrate for biosynthesis of guanosine 5'-diphosphate (GDP)-L: -fucose. In this study, improvement of GDP-L: -fucose production was attempted by manipulatin...

Stacked and continuous helical self-assemblies of guanosine monophosphates detected by vibrational circular dichroism.

The aim of this study was to characterize self-assembled structures of guanosine derivatives in aqueous solutions by vibrational circular dichroism (VCD) and electronic circular dichroism (ECD). Three...