Search Results for "Halogen Bonds"
Original Source: Halogen bonds form the basis for selective P-TEFb inhibition by DRB.
Cdk9, the kinase of the positive transcription elongation factor b, is required for processive transcription elongation by RNA polymerase II. Cdk9 inhibition contributes to the anticancer activity of many Cdk inhibitors under clinical investigation and hence there is interest in selective Cdk9 inhibitors. DRB (5,6-dichlorobenzimidazone-1-β-D-ribofuranoside) is a commonly used reagent for Cdk9 inhibition in cell biology studies. The crystal structures of Cdk9 and Cdk2 in complex with DRB reported here descr...
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Small change for a big improvement – halogen bonds and drug discovery
Halogen bonding has been applied in crystal engineering, materials research, and nanotechnology for some time. Scientists from the Heidelberg Institute for Theoretical Studies (HITS) and the Czech Ac...
Small change for big improvement: Halogen bonds and drug discovery
Halogen bonding has been applied in crystal engineering, materials research, and nanotechnology for some time. Scientists have now developed a new tool to use halogen bonds for drug discovery applicat...
Halogen-bonding-triggered supramolecular gel formation
Supramolecular gels whose properties can be tuned through non-covalent interactions — typically metal coordination or hydrogen bonding — are attracting attention in various fields. Researchers hav...
Targeting allosteric disulphide bonds in cancer
Allosteric disulphide bonds regulate the function of the mature proteins in which they reside. This Opinion article discusses the progress in our ability to identify and disrupt allosteric disulphide...
Barry Bonds' lawyer seeks to overturn conviction
SAN FRANCISCO (Reuters) - A lawyer for Barry Bonds told an appellate court on Wednesday that it should strike down the home run king's felony obstruction of justice conviction tied to a probe of stero...
Here's a recent paper in J. Med. Chem. on halogen bonding in medicinal chemistry. I find the topic interesting, because it's an effect that certainly appears to be real, but is rarely (if ever) exploi...
CORRECTED-Social impact investing catches on in the U.S.
(Corrects paragraph 17 to delete rating on Calvert bonds; the bonds are not rated securities)
TEXT-Fitch rates Group Health bonds 'BBB-', cuts IFS
May 21 - Fitch Ratings has assigned 'BBB-' ratings to Group Health Cooperative's (GHC) planned issue of $225 million of senior secured bonds with a mix of five and 10 year maturities. Concurrent...
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The character of the cooperativity between the HOX···OH/SH halogen bond (XB) and the Y-H···(H)OX hydrogen bond (HB) in OH/SH···HOX···HY (X = Cl, Br; Y = F, Cl, Br) complexes has been inves...
Structural Competition between Halogen Bonds and Lone-Pair⋅⋅⋅π Interactions in Solution.
Structural competition between halogen bonds and lone-pair⋅⋅⋅π interactions in solution is studied using (13) C NMR combined with density functional theory calculations. Among the halogen bonds...
The properties and applications of halogen bonds are dependent greatly on their strength. In this paper, we suggested some measures for enhancing the strength of the halogen bond relative to the hydro...
Halogen Bond Involving Hypervalent Halogen: CSD Search and Theoretical Study.
The Cambridge Structure Database search shows that there are over seventy crystal structures containing halogen bonds in which hypervalent halogens, not monovalent halogens as usual, behave as accepto...
Ditopic Ion Transport Systems: Anion-π Interactions and Halogen Bonds at Work.
Single-atom exchange series are introduced to extract the individual contributions of halogen bonds and anion-π interactions to the transport of anions across lipid bilayer membranes. Known cation bi...
