Eligard

Eligard® is a hormone compound for the treatment of advanced, hormone-dependent prostate cancer. The active ingredient (leuprolide acetate) significantly reduces the level of the male sex hormon...

Generics Drugs - news, views, reports

A generic drug (generic drugs, short: generics) is a drug defined as "a drug product that is comparable to brand/reference listed drug product in dosage form, strength, route of administration,...

PolyXen

PolyXen® is an enabling technology for protein drug delivery.  It uses the natural polymer polysialic acid (PSA) to prolong the active life and improve the stability of therapeutic peptides...

Dialysis: Heparin-free haemodialysis—use and outcomes

Shen et al. report that heparin-free haemodialysis is not associated with a decreased risk of death, bleeding, atherothrombosis and venous thromboembolism compared with standard haemodialysis using h...

New Medical Tool Could Help Surgeons Carrying Out Complex Procedures In The Operating Theatre

Researchers have developed a dye which provides a quick and accurate method of checking heparin levels in the blood. Heparin is an important anti-coagulant which has a significant role in major surger...

USP Announces Change in Labeling Requirement for Total Strength of Heparin to Help Minimize Medication Errors

To address safety concerns about the expression of drug strength on labels for heparin sodium injections and heparin lock flush solutions, the U.S. Pharmacopeial Convention (USP) has revised its curre...

Protamine–heparin complex antibodies raise concerns

Almost a third of patients treated with protamine for heparin reversal during cardiopulmonary bypass develop antibodies to circulating protamine–heparin complexes, study findings suggest.

Five Years Later, Legacy Biologics Still Face ‘Next Heparin’ Risks

Several factors continue to slow efforts to modernize legacy biologics’ compendial monographs against fake ingredients like the ones someone put in heparin in 2008. Hyaluronate, the ‘poster childâ...

[Comment] Anticoagulant therapy in acute brain ischaemia

Thrombosis plays an important part in acute ischaemic stroke, and antithrombotic therapies are a logical approach to treatment. Heparin has been advocated for acute stroke since the 1950s, and by the...

Heparin and Implantation: Any Aid for ART?

This viewpoint covers a study that examines the benefits of heparin on implantation failure after in vitro fertilization. Medscape Ob/Gyn

Thrombocytopenia common with heparin prophylaxis

NEW YORK (Reuters Health) - Thrombocytopenia is common with routine heparin prophylaxis of venous thromboembolism, researchers warn.

Sustained Release of Heparin on Enlarged-Pore and Functionalized MCM-41.

Mesoporous silica MCM-41 and SBA-15 were chosen to study the adsorption and release of bulky biomolecule heparin, in order to develop new heparin controlled delivery system and expand the application...

Heparin mapping using heparin lyases and the generation of a novel low molecular weight heparin.

Seven pharmaceutical heparins were investigated by oligosaccharide mapping by digestion with heparin lyase 1, 2, or 3, followed by high performance liquid chromatography analysis. The structure of one...

Substitution of a heparin correlation value for activated partial thromboplastin time in heparin nomograms.

Purpose Use of nomograms based on the "heparin correlation value" (HCV)-a value that corresponds to measured activated partial thromboplastin time (aPTT) and that removes the need to revise nomograms...

Non-recovery of ACT in a patient with heparin-induced thrombocytopenia type II during mitral valve replacement using argatroban anticoagulation.

Argatroban was used as the anticoagulant during cardiopulmonary bypass (CPB) in a patient with heparin-induced thrombocytopenia (HIT) type II undergoing mitral valve replacement. Dosage was reduced be...

Effect of Therapeutic INR on Activated Clotting Times, Heparin Dosage, and Bleeding Risk During Ablation of Atrial Fibrillation.

Effect of INR on Anticoagulation During Ablation of Atrial Fibrillation. Background: Ablation of atrial fibrillation (AF) with international normalized ratio (INR) >/= 2.0 is safe and may reduce throm...