Intracytoplasmic sperm injection

PolyXen

PolyXen® is an enabling technology for protein drug delivery.  It uses the natural polymer polysialic acid (PSA) to prolong the active life and improve the stability of therapeutic peptides...

CaptureSelect

BAC’s CaptureSelect products are affinity ligands and affinity resins created by a proprietary technology based on Camelid-derived single domain antibody fragments for the purification of biop...

Myc is the protein encoded by the MYC gene that activates the cell cycle

Myc is the protein encoded by the MYC gene that activates the cell cycle. It promotes cell replication through genetic coding for p14, inhibiting MDM2 and preventing the degradation of the pro-apopt...

KYNAMRO

KYNAMRO (mipomersen sodium) injection is an oligonucleotide inhibitor of apolipoprotein B-100 synthesis indicated as an adjunct to lipid-lowering medications and diet to reduce low density lipoprote...

New Medical Tool Could Help Surgeons Carrying Out Complex Procedures In The Operating Theatre

Researchers have developed a dye which provides a quick and accurate method of checking heparin levels in the blood. Heparin is an important anti-coagulant which has a significant role in major surger...

A heparin-mimicking polymer conjugate stabilizes basic fibroblast growth factor

Basic fibroblast growth factor (bFGF) is crucial for a range of diverse cellular processes, from wound healing to bone regeneration, yet is inherently unstable. This important biologic has now been co...

USP Announces Change in Labeling Requirement for Total Strength of Heparin to Help Minimize Medication Errors

To address safety concerns about the expression of drug strength on labels for heparin sodium injections and heparin lock flush solutions, the U.S. Pharmacopeial Convention (USP) has revised its curre...

Protamine–heparin complex antibodies raise concerns

Almost a third of patients treated with protamine for heparin reversal during cardiopulmonary bypass develop antibodies to circulating protamine–heparin complexes, study findings suggest.

Five Years Later, Legacy Biologics Still Face ‘Next Heparin’ Risks

Several factors continue to slow efforts to modernize legacy biologics’ compendial monographs against fake ingredients like the ones someone put in heparin in 2008. Hyaluronate, the ‘poster childâ...

[Review] Heparin-induced skin lesions

Heparins are widely used for prophylaxis and treatment of thromboembolic diseases. Besides bleeding complications, heparin-induced skin lesions are the most frequent unwanted adverse effects of subcut...

[Comment] Anticoagulant therapy in acute brain ischaemia

Thrombosis plays an important part in acute ischaemic stroke, and antithrombotic therapies are a logical approach to treatment. Heparin has been advocated for acute stroke since the 1950s, and by the...

Heparin and Implantation: Any Aid for ART?

This viewpoint covers a study that examines the benefits of heparin on implantation failure after in vitro fertilization. Medscape Ob/Gyn

Compatibility and stability of telavancin and vancomycin in heparin or sodium citrate lock solutions.

Purpose The compatibility and stability of telavancin and vancomycin in heparin or sodium citrate lock solutions were evaluated. Methods Telavancin and vancomycin hydrochloride injection powder lyophi...

The effect of local dry heat pack application on recovering the bruising associated with the subcutaneous injection of heparin.

AIMS AND OBJECTIVES: To determine the effect of the local dry heat pack application on recovering or alleviating the bruising associated with the subcutaneous injection of heparin. BACKGROUND: In stud...

Heparin mapping using heparin lyases and the generation of a novel low molecular weight heparin.

Seven pharmaceutical heparins were investigated by oligosaccharide mapping by digestion with heparin lyase 1, 2, or 3, followed by high performance liquid chromatography analysis. The structure of one...

Fluorescent reporters of thrombin, heparin cofactor II, and heparin binding in a ternary complex.

Thrombin inactivation by heparin cofactor II (HCII) is accelerated by ternary complex formation with heparin. The novel active-site-labeled thrombins, [4'F]FPR-T and [6F]FFR-T, and the exosite I probe...

Reversible binding and quantification of heparin and chondroitin sulfate in water using redox-stable biferrocenylene SAMs.

A biferrocenylene (BFD) thiol conjugate was prepared and self-assembled on a gold surface. The resulting SAMs with their extraordinary stability in the monocationic state were used to detect and quant...