Kaposi's sarcoma-associated herpesvirus RTA promotes degradation ...
Moreover, a Cys-plus-His-rich region within RTA is important for RTA-mediated degradation of Hey1. We confirm that Hey1 represses the RTA promoter and, ...
http://www.ncbi.nlm.nih.gov/pubmed/19369342...
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Identification of p53 regulators by genome-wide functional analysis
... protein by mechanisms that block the HDM2-mediated degradation of p53 (10). ..... The fact that HEY1 and HES1 modulate p53 activity and are regulated by ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=37...
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Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during ...
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular ... Cell Cycle Proteins; F-Box Proteins; Fbxw7 protein, mouse; Hey1 protein, mouse
...
http://www.ncbi.nlm.nih.gov/pubmed/14672936...
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Current Biology - Glycogen Synthase Kinase-3β Modulates Notch ...
TLR- and Notch-induced Hes1 and Hey1 attenuated IL-6 and IL-12 production. ... and promotes hyperphosphorylation and degradation of the Notch ICD in vivo. ...
http://www.cell.com/current-biology/abstract/S0960-9822(02)0...
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Notch1 is an effector of Akt and hypoxia in melanoma development
In contrast, shNotch1 significantly decreased Notch1, HES1, and HEY1 ..... HEY1, HES related with yrpw motif 1; IκBαM, degradation-resistant mutant of IκBα; ...
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567838/...
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Hemostasis, Thrombosis, and Vascular Biology: Overexpression of ...
The Notch1 and Hey123 genes, which are normally expressed specifically in the arterial ... Degradation of the extracellular matrix is a crucial step to the
...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=25...
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High levels of Notch signaling down-regulate Numb and Numblike
This suggests that degradation rather than the synthesis rate is affected ... High-titer stocks of adenoviruses for Notch 1 ICD, Hes 1, and Hey 1 were used
...
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064589/...
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Notch signaling mediates hypoxia-induced tumor cell migration and ...
... followed by degradation by the proteasome (13, 14). .... Hes-1, Hey-1, or EGFP (A) or after exposure to hypoxia in the presence or absence of (more ...)
...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=23...
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Loss of Notch signalling induced by Dll4 causes arterial calibre ...
By in situ hybridization on Dll4-/- sections we did not detect Hey1 mRNA in the .... production or active degradation of the basement membrane components. ...
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637862/...
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Hey Basic Helix-Loop-Helix Transcription Factors Are Repressors of ...
After degradation of the RNA template the cDNA was labeled with Cy5 .... Basic helix-loop-helix domain of Hey1 is essential for repression activity. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=12...
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