Diabetes Mellitus in Pregnancy Gestational Diabetes

Diabetes

2.8 million people in the UK have been diagnosed with diabetes in the UK and a further 850,000 people are undiagnosed. Diabetes is characterized by high blood glucose levels, resulting from a prob...

Brittle diabetes

Diabetes Mellitus DM

Nephrogenic Diabetes Insipidus

Become a marathon runner with the protein PGC-1alpha

Even with a greater muscle mass, a sprinter cannot win a marathon. His specially-trained and strengthened muscles will fatigue faster than the endurance-trained muscles of a long distance runner. Medi...

Regulation von HIF-1alpha bei Immunprozessen

Wissenschaftler der Universitätskliniken Jena, Charité, Regensburg und von der HU Berlin konnten...

Inducible Protein Protects Muscle Tissue from Chronic Disease-Related Atrophy

An isoform of the protein PGC-1alpha that stimulates muscle growth has been found to be induced in muscle by...

GeneTex to introduce new antibody against hypoxia-inducible factor 1alpha

GeneTex, Inc., a leading manufacturer of antibodies, has announced that they will be launching a new antibody against HIF1a (hypoxia-inducible factor 1alpha).

GeneTex to launch new Hypoxia antibody

US based antibody producer, GeneTex, is planning to launch a new antibody against HIF1a (hypoxia-inducible factor 1alpha).

PGC-1alpha and TFEB provide two new therapeutic targets for Huntington's disease

In a paper published in the July 11 online issue of Science Translational Medicine, researchers at the University of California, San Diego School of Medicine have identified two key regulatory protein...

Diabetes Could Be Reduced With Aggressive Treatment Of Pre-Diabetes, Study

Treating pre-diabetes early and aggressively with intensive lifestyle changes or medication could be an effective way to significantly reduce the chances of developing type 2 diabetes later. This wa...

Type 1 Diabetes Vaccine In Twenty Years? Could Well Be

Diabetes UK have announced the biggest research program in the charity's history to try and develop a new vaccine for Type 1 diabetes within the next two decades, an accomplishment which could transfo...

Maturity-Onset Diabetes of the Young (MODY) caused by a Novel Nonsense Mutation E41X in the HNF-1alpha Gene.

The most common cause of Maturity-Onset Diabetes of the Young (MODY) are mutations in the Hepatic Nuclear Factor 1alpha (HNF-1alpha) gene, resulting in MODY3. In a family afflicted with diabetes, a no...

PGC-1{alpha} Increases PDH Content But Does Not Change Acute PDH Regulation In Mouse Skeletal Muscle.

The aim was to test if the transcriptional coactivator peroxisome proliferator-activated receptor (PPAR)-gamma coactivator (PGC)1alpha regulates the content of pyruvate dehydrogenase (PDH)-E1alpha and...

CC-chemokine MIP-1alpha in the spinal cord contributes to nerve injury-induced neuropathic pain.

We investigated the involvement of spinal macrophage inflammatory protein-1alpha (MIP-1alpha), an inflammatory chemokine, in partial sciatic nerve ligation (PSL)-induced neuropathic pain in mice. PSL...

Glucose is necessary for stabilization of hypoxia-inducible factor-1alpha under hypoxia: contribution of the pentose phosphate pathway to this stabilization.

In this study, we observed that low glucose or fructose reduces the increase in hypoxia-inducible factor-1alpha (HIF-1alpha) protein under hypoxic conditions. 6-Aminonicotinamide (6-AN), an inhibitor...

The interaction between different types of activated RAW 264.7 cells and macrophage inflammatory protein-1 alpha.

ABSTRACT: BACKGROUND: Two major ways of macrophage (MPhi) activation can occur in radiation-induced pulmonary injury (RPI): classical and alternative MPhi activation, which play important roles in the...