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Search Results for "How Do You Test For P2y Receptor"

12:34 EDT 19th June 2013 | BioPortfolio

Original Source: Benzofuran-substituted urea derivatives as novel P2Y(1) receptor antagonists.

Benzofuran-substituted urea analogs have been identified as novel P2Y(1) receptor antagonists. Structure-activity relationship studies around the urea and the benzofuran moieties resulted in compounds having improved potency. Several analogs were shown to inhibit ADP-mediated platelet activation.

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Evidence for the existence of dopamine d2-oxytocin receptor heteromers in the ventral and dorsal striatum with facilitatory receptor–receptor interactions

Cloning of a Genomic DNA Fragment Containing the Guinea Pig CXCR1 Gene, A Specific Receptor for Guinea Pig Interleukin-8

e present invention relates to cloning of a genomic DNA fragment containing the guinea pig CXCR1 gene, a specific receptor for guinea pig interleukin-8 (IL-8). More specifically, the IL-8-CXCR1 axis...

Leiden researchers achieve highest resolution ever for human protein

Receptor The protein in question is the adenosine A2A receptor, the main receptor for caffeine in the human body. This receptor is also linked to Parkinson's disease. The class of around 800 protei...

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Comparison of prognostic values between combined immunohistochemical score of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67 and the corresponding gene expression score in breast cancer

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Advancing Understanding Of Brain Receptor May Help Fight Neurological Disorders

For several years, the pharmaceutical industry has tried to develop drugs that target a specific neurotransmitter receptor in the brain, the NMDA receptor. This receptor is present on almost every neu...

Scientists advance understanding of brain receptor; may help fight neurological disorders

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Optimization of (Arylpiperazinylbutyl)oxindoles Exhibiting Selective 5-HT(7) Receptor Antagonist Activity.

A series of (arylpiperazinylbutyl)oxindoles as highly potent 5-HT(7) receptor antagonists has been studied for their selectivity toward the 5-HT(1A) receptor and α(1)-adrenoceptor. Several derivative...

Lack of association between the P2X7 receptor A1513C polymorphism and susceptibility to pulmonary tuberculosis: a meta-analysis.

SUMMARY AT A GLANCE: The results from this first meta-analysis indicated that there is no association between the P2X7 receptor A1513C polymorphism and susceptibility to pulmonary tuberculosis. ABSTRA...

Involvement of dopamine receptors in the antidepressant-like effect of melatonin in the tail suspension test.

Melatonin was previously shown to produce an antidepressant-like effect in the tail suspension test. In this work the mechanisms underlying its antidepressant-like effect were further studied by inves...

5-HT(1A) receptor and apoptosis contribute to interferon-α-induced "depressive-like" behavior in mice.

Interferon-α (IFN-α)-induced "depressive-like" behavior is a major limitation for the treatment of hepatitis C virus (HCV), especially for patients with psychiatric disorders. Recently, serotonin 1A...

Role of 5-HT(1A) and 5-HT(1B) receptors in the antidepressant-like effect of piperine in the forced swim test.

Our previous studies have showed that treating mice with piperine significantly decreased the immobility time of the animals in the forced swim test and tail suspension test, which was related to up-r...

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