Search Results for "Human Trials Of Silencing Rna"
Original Source: Effects of RNA interference-mediated gene silencing of JMJD2A on human breast cancer cell line MDA-MB-231 in vitro.
ABSTRACT: Previous data demonstrate that JMJD2A is a cancer-associated gene and may be involved in human breast cancer by demethylation of H3K9me3. The aim of this study was to investigate depressive effects on JMJD2A by transfection with JMJD2A-sepcific siRNA in human breast cancer cell line MDA-MB-231 and effects on cell proliferation, invasion and migration. JMJD2A-specific siRNA was chemically synthesised and transfected into human breast cancer cell line MDA-MB-231. Expression levels of JMJD2A were det...
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A team led by scientists at The Scripps Research Institute (TSRI) has found how to boost or inhibit a gene-silencing mechanism that normally serves as a major controller of cells' activities. The disc...
Extremely stable Piwi-induced gene silencing in Caenorhabditis elegans
RNA-induced epigenetic silencing (RNAe) is a new pathway in C. elegans initiated by the Piwi protein PRG-1. RNAe stably silences transgenes over many generations through a nuclear RNAi pathway that in...
Convergent transcription induces transcriptional gene silencing in fission yeast and mammalian cells
Previous studies have shown the potential for convergent transcription as a way to induce gene silencing. This Technical Report now demonstrates that introducing convergent transcription plasmids into...
Oomycete pathogens encode RNA silencing suppressors
Wenbo Ma and colleagues show that two effectors from the oomycete plant pathogen Phytophthora sojae suppress RNA silencing in plants by inhibiting the biogenesis of small RNAs. These findings show tha...
New Informative Guide to Gene Silencing & Delivery Launched by AMSBIO (News)
14 June 2012: Aningdon, UK - A new guide entitled 'Top Ten Tips for Gene Silencing & Delivery' is available from AMSBIO. Drawing upon extensive experience of gene silencing techniques the new ...
Type: Original PaperPurposeTo determine the influence of physicochemical properties of lipid nanoparticles (LNPs) carrying siRNA on their gene silencing in vivo. Mechanistic understanding of how the a...
ADAR1 As Gene-Silencing Modular RNA Multitool
RNA, once considered a bit player in the grand scheme by which genes encode protein, is increasingly seen to have a major role in human genetics. In a study presented in the journal Cell, researchers...
BH3-only protein silencing contributes to acquired resistance to PLX4720 in human melanoma
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A microRNA embedded AAV alpha-synuclein gene silencing vector for dopaminergic neurons.
Alpha-synuclein (SNCA), an abundantly expressed presynaptic protein, is implicated in Parkinson's disease (PD). Since over-expression of human SNCA (hSNCA) leads to death of dopaminergic (DA) neurons...
Silencing SATB1 inhibits proliferation of human osteosarcoma U2OS cells.
It has been shown that over-expression of Special AT-rich binding protein 1 (SATB1) in breast cancer predicts a poor prognosis. This study was aimed at investigating the effects of silencing SATB1 on...
Poly ADP-ribose polymerase (PARP) which is closely related to Poly ADP-ribose glycohydrolase (PARG) has already been thoroughly investigated in both experimental and clinical cancer trials compared to...
Mammalian hyperplastic discs Homolog EDD Regulates miRNA-Mediated Gene Silencing.
MicroRNAs (miRNAs) regulate gene expression through translation repression and mRNA destabilization. However, the molecular mechanisms of miRNA silencing are still not well defined. Using a genetic sc...
Killer Ig-like receptors (KIRs) are expressed in a variegated, clonally restricted fashion on NK cells and are important determinants of NK cell function. Although silencing of individual KIR genes is...
