Search Results for "Hyponatremia In Capd The Role Of Icodextrin"
Original Source: Hyponatremia and Hypokalemia in Patients on Peritoneal Dialysis.
Hypokalemia occurs in up to 60% of patients on peritoneal dialysis (PD) for end-stage renal disease. It can be associated with poor clinical outcomes, including malnutrition and death. New evidence points to a link between hypokalemia and the risk of peritonitis. The serum Na(+) concentration is determined by the ratio of exchangeable Na(+) and K(+) to total body water. Hyponatremia may be caused by excessive thirst, a particular problem in patients on PD. Consistent with the relationship among the serum so...
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Cornerstone’s Hyponatremia Therapy Lixivaptan Will Get Advisory Panel Scrutiny
The hyponatremia drug is a selective vasopressin V2-receptor antagonist, like Astellas’ Vaprisol and Otsuka’s Samsca.
Lixivaptan for Hyponatremia—The Numbers Game Lixivaptan for Hyponatremia
On September 13, 2012, the Cardiovascular and Renal Drugs Advisory Committee of the US Food and Drug Administration (FDA) reviewed lixivaptan, a new vasopressin receptor antagonist. These agents corre...
Study links hyponatremia with increased risk of death, complications following surgery
An observational study of nearly 1 million patients who underwent surgery suggests that preoperative hyponatremia (an electrolyte disorder in which sodium levels in the blood are low) was associated w...
FDA to discuss Cornerstone's lixivaptan
FDA's Cardiovascular and Renal Drugs Advisory Committee will meet on Sept. 13 to discuss an NDA from Cornerstone Therapeutics Inc. (NASDAQ:CRTX) for lixivaptan to treat symptomatic hypervolemic hypona...
Where vaptans do and do not fit in the treatment of hyponatremia
Otsuka's tolvaptan gets Priority Review
Otsuka Pharmaceutical Co. Ltd. (Tokyo, Japan) said FDA accepted and granted Priority Review to an NDA for tolvaptan to treat autosomal dominant polycystic kidney disease. The PDUFA date is Sept. 1. La...
Mild hyponatremia is associated with an increased risk of death in an ambulatory setting
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Pd(2+)-Incorporated Perovskite CaPd(3)B(4)O(12) (B = Ti, V).
Novel A-site ordered perovskites CaPd(3)Ti(4)O(12) and CaPd(3)V(4)O(12) were synthesized under high-pressure and high-temperature of 15 GPa and 1000 °C. These compounds are the first example in which...
Impacts of icodextrin on integrin-mediated wound healing of peritoneal mesothelial cells.
Exposure to glucose and its metabolites in peritoneal dialysis fluid (PDF) results in structural alterations of the peritoneal membrane. Icodextrin-containing PDF eliminates glucose and reduces deteri...
Hyponatremia and bone: an emerging relationship.
Hyponatremia is the most common electrolyte disorder and is mainly known for its neurological complications. New studies suggest previously unrecognized complications of hyponatremia, including falls,...
Ureaplasma urealyticum CAPD-associated Peritonitis Diagnosed by 16S rDNA PCR.
In some patients with peritonitis complicating continuous ambulatory peritoneal dialysis (CAPD), a causative organism is never identified. We report a case of Ureaplasma urealyticum CAPD-associated pe...
The potential role for lixivaptan in heart failure and in hyponatremia.
Introduction: Hypervolemia and hyponatremia are common features in heart failure and have been associated with increased morbidity and mortality. Stimulation of arginine vasopressin (AVP) plays an imp...
