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[Comment] Anti-interleukin-2 receptor alpha for multiple sclerosis?

In The Lancet, Ralf Gold and colleagues report the results of their 52-week, randomised, placebo-controlled, dose-ranging, phase 2 study of daclizumab high-yield process (HYP)—a humanised monoclonal...

Induction of M2-like macrophages in recipient NOD-scid mice by allogeneic donor CD4+CD25+ regulatory T cells

Inhibition of activation induced CD154 on CD4+ CD25− cells: a valid surrogate for human Treg suppressor function

Increased circulating IL-2Rα (CD25) predicts poor outcome in both indolent and aggressive forms of mastocytosis: a comprehensive cytokine–phenotype study

Glucocorticoid-induced TNFR Family-Related Receptor Ligand (GITRL) Antibodies for Diagnosis and Treatment of Immune System Disorders

This technology provides novel antibodies and methods for diagnostics and treatment of disorders arising from dysregulation of the immune system using antibodies directed against glucocorticoid-induce...

Through 2021, The Number of Disease-Modifying Therapies Approved for The Treatment of Multiple Sclerosis is Expected to Double, Intensifying Market Fragmentation

Decision Resources, one of the world’s leading research and advisory firms for pharmaceutical and healthcare issues, finds that, through 2021, the number of disease-modifying th...

Biogen Idec’s Commitment to MS Demonstrated Through Significant Scientific Data Being Presented at the 28th ECTRIMS

Biogen Idec (NASDAQ: BIIB) will have extensive data from the company’s leading multiple sclerosis (MS) franchise presented during the 28th Congress of the European Commit...

Foxp3 Expression in Bovine CD8(+) T Cells Is Associated with the Intensity of CD25 Expression.

The aim of the undertaken research was to determine whether Foxp3(+)CD25(+)CD8(+) cells exist in cattle and whether Foxp3 expression in CD8(+) T cells is correlated with the intensity of CD25 expressi...

Regulatory T Cell Properties of Chicken CD4+CD25+ Cells.

Chicken CD4(+)CD25(+) cells were characterized for mammalian regulatory T cells' suppressive and cytokine production properties. Anti-chicken CD25 mAb was produced in mice and conjugated with a fluore...

The suppressive effect of CD25+Treg cells on Th1 differentiation requires cell-cell contact partially via TGF-β production.

CD4+CD25+Foxp3+ regulatory T cells (CD25+Treg cells) play a central role in the maintenance of peripheral self-tolerance and immune homeostasis. Previous study showed that CD25+Treg cells suppressed t...

Inhibition of osteoclast differentiation and matrix metalloproteinase production by CD4+CD25+ T cells in mice.

To reveal the mechanism of inflammation-accompanied osteoporosis, mouse CD11b cells and CD4+CD25+ T cells were cocultured. Our results showed that CD11b+ monocytes cocultured with CD4+CD25+ T cells ge...

Efficient induction of CD25- iTreg by co-immunization requires strongly antigenic epitopes for T cells.

ABSTRACT: BACKGROUND: We previously showed that co-immunization with a protein antigen and a DNA vaccine coding for the same antigen induces CD40low IL-10high tolerogenic DCs, which in turn stimulates...