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Inflammasomes: Microtubules pull mitochondria to NLRP3

Microtubule-dependent relocalization of the mitochondria is required for activation of the NLRP3 inflammasome.

Controlling mood through the motions of mitochondria

(Medical Xpress)—Regulating the distribution of power in neurons is done by a system that makes the national electric grid look simple by comparison. Each neuron has several thousand mitochondria co...

Researchers define how a gene mutated in Parkinson's disease may normally function to ensure neuronal health

(Medical Xpress)—Cell biologists studying Parkinson's disease are training their sights on mitochondria, the energy source of the cell, whose activity in neurons appears to go awry in this devastati...

Promising Treatment for Parkinson's Disease Prevents Mitochondria-JNK Interaction

Neurodegenerative disease researchers have found that blocking the translocation of the enzyme JNK to the mitochondria or inhibiting...

BioVision Introduces Three New Assay Kits: Yeast Mitochondria Isolation Kit, Mitochondrial Protein IP Kit & Cytochrome Oxidase Activity Colorimetric Assay Kit

BioVision is thrilled to introduce Three Brand New Assay Kits: Yeast Mitochondria Isolation Kit- A highly efficient kit to isolate intact yeast mitochondria, Mitochondrial Protein IP Kit - For IP/Co-I...

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

Alzheimer disease (AD) associated (gamma)-secretase components presenilin-1 and -2 accumulate in MAM, an LR-like ER subcompartment connected to mitochondria. MAM function increases in patients with fa...

Autophagosomes form at ER–mitochondria contact sites

Autophagy is a tightly regulated intracellular bulk degradation/recycling system that has fundamental roles in cellular homeostasis. Autophagy is initiated by isolation membranes, which form and elong...

Endoplasmic reticulum–mitochondria contacts: function of the junction

The characterization of dynamic contacts that form between the endoplasmic reticulum and mitochondria have highlighted the different ways in which the functions of these organelles can be coordinated....

Germ-line mitochondria exhibit suppressed respiratory activity to support their accurate transmission to the next generation.

Mitochondria are accurately transmitted to the next generation through a female germ cell in most animals. Mitochondria produce most ATP, accompanied by the generation of reactive oxygen species (ROS)...

piRNAs Meet Mitochondria.

zuc/MitoPLD encodes a conserved enzyme that localizes to mitochondria and hydrolyzes the mitochondria-specific lipid cardiolipin. Surprisingly, zuc/MitoPLD activity is required for Piwi-interacting RN...

Targeting of proapoptotic TLR adaptor, SARM, to mitochondria: definition of critical region and residues in the signal sequence.

The fifth and the most well conserved member of the TLR adaptor, SARM, has been reported to be an important mediator of apoptosis. However, the exact cellular localization of SARM with respect to its...

On the properties of calcium-induced permeability transition in neonatal heart mitochondria.

Permeability transition was examined in heart mitochondria isolated from neonate rats. We found that these mitochondria were more susceptible to Ca(2+)-induced membrane leakiness than mitochondria fro...

Mitochondria-Targeted Small Molecule Therapeutics and Probes.

Mitochondrial function is central to a wide range of biological processes in health and disease and there is considerable interest in developing small molecules that are taken up by mitochondria and a...