Search Results for "Immune Homeostasis And Autoimmune"
Original Source: Regulatory B cells in autoimmune diseases and mucosal immune homeostasis.
B lymphocytes contribute to physiological immunity through organogenesis of secondary lymphoid organs, presentation of antigen to T cells, production of antibodies, and secretion of cytokines. Their role in several autoimmune diseases, mainly as producers of pathogenic antibodies, is also well known. However, certain subsets of B cells are emerging as the important regulatory cell populations in both mouse and human. The regulatory functions of B cells have been demonstrated in a variety of mouse models of...
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Autoimmune Rheumatic Disorders
Immunology is the study of immunity and the defence mechanisms of the body. A greater understanding of immunology is needed to develop vaccines, understand and prevent autoimmune condtions, cancers...
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A20: linking a complex regulator of ubiquitylation to immunity and human disease
Human genetic studies associate defective A20 activity with autoimmune and autoinflammatory diseases, as well as with cancer. Here, Ma and Malynn discuss the complex mechanisms through which A20 may c...
Link Between Immune Cell Death Defects And Autoimmune Diseases
Melbourne researchers have discovered that the death of immune system cells is an important safeguard against the development of diseases such as type 1 diabetes, rheumatoid arthritis and lupus, which...
Excess dietary salt may drive the development of autoimmune diseases
Increased dietary salt intake can induce a group of aggressive immune cells that are involved in triggering and sustaining autoimmune diseases. In autoimmune diseases, the immune system attacks health...
T cells out of control—impaired immune regulation in the inflamed joint
In this Review, the authors summarize the latest findings on changes in effector T-cell homeostasis in autoimmune disease and discuss how mechanisms that normally regulate these cells are affected in...
International study: Excess dietary salt may drive the development of autoimmune diseases
(Helmholtz Association of German Research Centres) Increased dietary salt intake can induce a group of aggressive immune cells that are involved in triggering and sustaining autoimmune diseases. This...
The gut microbiota — masters of host development and physiology
The gut microbiota, traditionally studied in the context of disease, has emerged as a key regulator during normal homeostasis. Here, Sommer and Bäckhed discuss how the gut microbiota promotes the dev...
Immune cell death safeguards against autoimmune disease
Researchers at the Walter and Eliza Hall Institute have discovered that a pair of molecules work together to kill so-called 'self-reactive' immune cells that are programmed to attack the body's own or...
Salt May Play Role In Autoimmune Disease
A healthy immune system is a finely balanced system: too little activity and we fall prey to disease, too much, and it attacks our own tissue, triggering autoimmune diseases like multiple sclerosis....
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Much evidence has identified a direct anatomical and functional link between the brain and the immune system, with glucocorticoids (GCs), catecholamines (CAs), and neuropeptide Y (NPY) as its end-poin...
Regulatory B cells in autoimmune diseases and mucosal immune homeostasis.
B lymphocytes contribute to physiological immunity through organogenesis of secondary lymphoid organs, presentation of antigen to T cells, production of antibodies, and secretion of cytokines. Their r...
The odd couple: A fresh look at autoimmunity and immunodeficiency.
The paradoxical relationship between immunodeficiency (under-responsiveness) and autoimmunity (over-responsiveness) affecting the immune system was debated at the Fourth AARDA Colloquium on cross-disc...
Commensal gut flora and brain autoimmunity: a love or hate affair?
Multiple sclerosis (MS) and other chronic inflammatory autoimmune diseases represent major public health challenges in industrialised Western society. MS results from an autoimmune attack against myel...
The molecular mechanism which enables activated immune cells to cross the blood-retinal barrier in spontaneous autoimmune uveitis is yet to be unraveled. Equine recurrent uveitis is the only spontaneo...
