Spinal cord

The spinal cord is a bundle of nerves that descends through the bottom of the skull from the base of the brain (brainstem) and descends to the bottom of the spine, where it thins, and becomes the ca...

Massachusetts

Located in the north-east corner of the USA, Massachusetts, has the third highest GDP of any state in America and is also a hotspot for the biotechnology industry. In addition to the globally renown...

Antisense

Antisense therapy is a form of treatment for genetic disorders or infections. When the genetic sequence of a particular gene is known to be causative of a particular disease, it is possible to synth...

Ventricular Tachycardia VT

Ventricular tachycardia is a pulse rate of more than 100 beats per minute, with at least three irregular heartbeats in a row. It is a major cause of sudden cardiac death. The condition can develop...

The Last First Base

Bio-IT World | First Base | I received an email alert over the weekend with the following title: "Kevin Davies Reflects on Emotional Goodbye." The story was about a professional soccer player in the...

Arizona's Luke Air Force Base gets F-35 mission

The Department of Defense has chosen Luke Air Force Base in Glendale for the new pilot training center for the F-35 fighter jets, city officials announced Wednesday.The 71-year-old base west of Phoen...

Identification of direct targets and modified bases of RNA cytosine methyltransferases

Covalent links formed between methylation enzymes and a 5-azacytidine base incorporated into cellular RNA allow target enrichment and single base-pair resolution modification mapping.

A map of nucleosome positions in yeast at base-pair resolution

A new technique for mapping nucleosomes genome-wide with single-base-pair accuracy, by chemical modification of engineered histones.

Evidence base needs to be developed for the whole process of end of life care

Despite the BMJ survey’s limitations,1 we welcome systematic attempts to develop the evidence base necessary to move forward the debate on the Liverpool care pathway (LCP).The Leeds Teaching...

Lucintel’s Analysis of Global Base Metal Mining Industry: Market to Reach $305 Billion in 2017

Irving, Texas (PRWEB) January 20, 2013 The global base metal mining industry experienced robust growth during the last five years. It is expected to continue to grow, but at a reduced pace, to reac...

Fosun Pharma Builds R&D Base At RMB 3.5 Billion, To Open In Two Years

Shanghai Fosun Pharmaceutical (Group) Co., Ltd. announced plans to construct an R&D base in Shanghai’s Zhangjiang Hi-Tech Park for RMB 3.5 billion ($562.23 billion).

Mylan Buys In India Help Form Sourcing Base For Global Operations

Mylan's presence in India is not so with an eye for the local market as it is as a sourcing base to expand its global operation.

Concise and efficient syntheses of preQ(1) base, Q base, and (ent)-Q base.

To thoroughly study the functional role of prokaryotic t-RNA-guanine-transglycosylases which are essential in the pathogenesis of shigellosis, novel efficient, high-yielding synthetic approaches for p...

Oligonucleotide Incorporation and Base Pair Stability of 9-Deaza-2'-deoxyguanosine, an Analogue of 8-Oxo-2'-deoxyguanosine.

9-Deaza-2'-deoxyguanosine (CdG) is a C-nucleoside and an analogue of the abundant promutagen 8-oxo-2'-deoxyguanosine (OdG). Like 2'-deoxyguanosine (dG), CdG should form a stable base pair with dC, but...

Enhanced base-pair opening in the adenine tract of a RNA double helix.

Proton exchange and nuclear magnetic resonance spectroscopy are being used to characterize the kinetics and energetics of base-pair opening in two nucleic acid double helices. One is the RNA duplex 5'...

Mechanistic details of the DNA recognition by the Dnmt1 DNA methyltransferase.

A recently solved Dnmt1-DNA crystal structure revealed several enzyme-DNA contacts and large structural rearrangements of the DNA at the target site, including the flipping of the non-target strand ba...

Pyrimidine-pyrimidine base pairs stabilized by silver(i) ions.

In the presence of Ag(I) ions, the C-T and m(5)iC (5-methylisocytosine)-T base pairs showed comparable stability to the C-Ag(I)-C base pair, and the m(5)iC-C base pair was highly stabilized by the syn...