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Research has not found any adverse effects from consuming vitamin E in food. However, high doses of alpha-tocopherol supplements can cause hemorrhage and interrupt blood coagulation in animals, and...
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Meta-analyses of Hydroxyethyl Starch for Volume Resuscitation
To the Editor: Most textbooks and guidance documents on systematic reviews discuss the caveats and potential risks of heterogeneity in meta-analysis. It is not appreciated that extreme homogeneity in...
Several meta-analysis conducted in the past suggest that survival of patients with advanced non-small cell lung cancer (NSCLC) is improved if first-line chemotherapy includes platinum derivatives. Re...
Cardiovascular Disease Risk Prediction Factors
To the Editor: The recent ERFC meta-analysis indicated that the standard hazard ratio (HR) for cardiovascular disease using baseline levels of non-HDL-C was 1.27 (95% CI, 1.22 to 1.33) vs 1.24 (1.19 t...
Demystifying trial networks and network meta-analysis
IntroductionWhen multiple interventions have been used and compared for the same disease and outcomes, network meta-analysis (also commonly referred to as a multiple treatment comparison...
Meta-Analysis Links Diabetes to Increased Blood Cancer Risk
According to a new, worldwide meta-analysis, patients with type 2 diabetes have a significantly increased risk of developing certain...
Meta-analysis shows most effective anti-shivering meds
NEW YORK (Reuters Health) - Meperidine, tramadol, and nefopam appear to be the most effective medications for post-anesthesia shivering, according to a new meta-analysis of 61 randomized trials.
Meta-analysis methods for genome-wide association studies and beyond
The authors review statistical methods for meta-analysis of genome-wide association studies (GWASs) and extensions of these methods to complex data. They discuss how low-frequency variants can be inco...
New Meta-Analysis on Sugar Sparks Old Debate
A meta-analysis showing that consumption of sugar increases body weight supports growing calls for tighter recommendations on intake; sugar-sweetened drinks are a particular culprit, as are refined ca...
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Comparison study of microarray meta-analysis methods.
ABSTRACT: BACKGROUND: Meta-analysis methods exist for combining multiple microarray datasets. However, there are a wide range of issues associated with microarray meta-analysis and a limited ability t...
Higher-order likelihood inference in meta-analysis and meta-regression.
This paper investigates the use of likelihood methods for meta-analysis, within the random-effects models framework. We show that likelihood inference relying on first-order approximations, while impr...
Meta-analysis methods for genome-wide association studies and beyond.
Meta-analysis of genome-wide association studies (GWASs) has become a popular method for discovering genetic risk variants. Here, we overview both widely applied and newer statistical methods for GWAS...
To derive a more precise estimation of the relationship between miR-149 C>T polymorphism and cancer risk, a meta-analysis was performed. A total of 8 studies including 4,677 cases and 4,830 controls w...
Estimating within-study covariances in multivariate meta-analysis with multiple outcomes.
Multivariate meta-analysis allows the joint synthesis of effect estimates based on multiple outcomes from multiple studies, accounting for the potential correlations among them. However, standard meth...
