Respiratory

Respiratory medicine is concerned with the study of the lungs and diseases that affect them. This includes lung cancers, pneumonia and other infections, fibrosis of the lungs, effusions, obstruction...

Cystic Fibrosis

Affecting over 8,500 people in the UK, Cystic Fibrosis (CF) is one of the UK's most common life-threatening inherited diseases. Around half of the CF population can expect to live over 38 year...

Fibrosis

Lungs

Fibrosis and Cirrhosis

Healthy lungs' microbes focus of study on cystic fibrosis

(Medical Xpress)—Healthy people's lungs are home to a diverse community of microbes that differs markedly from the bacteria found in the lungs of cystic fibrosis patients. That's the result of new r...

Identification of microbes in healthy lungs sheds light on cystic fibrosis

(Stanford University Medical Center) Healthy people's lungs are home to a diverse community of microbes that differs markedly from the bacteria found in the lungs of cystic fibrosis patients.

Between A ROCK And A Hard Place: Fasudil May Treat Pulmonary Fibrosis

Pulmonary fibrosis is a scarring or thickening of the lungs that causes shortness of breath, a dry cough, fatigue, chest discomfort, weight loss, a decrease in the ability of the lungs to transmit oxy...

Microbes Identified In Healthy Lungs Sheds Light On Cystic Fibrosis

Healthy people's lungs are home to a diverse community of microbes that differs markedly from the bacteria found in the lungs of cystic fibrosis patients. That's the result of new research from Stanfo...

Differences Seen in Lung Microbes of Cystic Fibrosis Patients

WEDNESDAY, Sept. 26 -- Marked differences exist between the communities of bacteria in the lungs of healthy people and those with cystic fibrosis, according to a new study. The findings could prove im...

Pitt researchers identify agent that can block fibrosis of skin, lungs

PITTSBURGH, May 30 – Researchers at the University of Pittsburgh School of Medicine have identified an agent that in lab tests protected the skin and lungs from fibrosis, a process that can ultimat...

DNA Sequencing Reveals Evidence For Mycobacterium abscessus Transmission Between Cystic Fibrosis Patients

Researchers at Papworth Hospital, the University of Cambridge and the Wellcome Trust Sanger Institute have discovered why a new type of dangerous bacterial infection has become more common among peopl...

Scientists identify mechanosensitive cellular signaling pathway in myofibroblasts

Pulmonary fibrosis is a scarring or thickening of the lungs that causes shortness of breath, a dry cough, fatigue, chest discomfort, weight loss, a decrease in the ability of the lungs to transmit oxy...

Transient Overexpression of Gremlin Results in Epithelial Activation and Reversible Fibrosis in Rat Lungs.

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic disease of the lung parenchyma, without curative treatment. Gremlin is a bone morphogenic protein (BMP) antagonist, its expression being i...

Role of CD95 in pulmonary inflammation and infection in cystic fibrosis.

Cystic fibrosis is caused by a defective expression of the cystic fibrosis transmembrane conductance regulator (Cftr) gene, which results in chronic pulmonary inflammation and infections. The pathophy...

TLR2-Mediated Production of IL-27 and Chemokines by Respiratory Epithelial Cells Promotes Bleomycin-Induced Pulmonary Fibrosis in Mice.

Idiopathic pulmonary fibrosis is a fatal disease characterized by progressive destruction of the lung. Although TLR2 bridges innate and adaptive immunity by sensing tissue damage, its role in pulmonar...

Reversible remodeling of lung tissue during hibernation in the Syrian hamster.

During hibernation, small rodents such as hamsters cycle through phases of strongly suppressed metabolism with low body temperature (torpor) and full restoration of metabolism and body temperature (ar...

Effects of montelukast, a cysteinyl-leukotriene type 1 receptor antagonist, on the pathogenesis of bleomycin-induced pulmonary fibrosis in mice.

Cysteinyl-leukotrienes are potent mediators involved in various inflammatory diseases and lung disorders such as asthma. However, their precise role in the pathogenesis of pulmonary fibrosis is unknow...