poly adenyl ribose polymerase PARP Inhibitors

Poly (ADP-ribose) polymerases (PARPs) are a family of nuclear enzymes implicated in the regulation of multiple physiological cellular functions, including DNA repair, gene transcription, protein modif...

Tumors

A tumor or tumour is the name for a neoplasm or a solid lesion formed by an abnormal growth of cells (termed neoplastic) which looks like a swelling. Tumor is not synonymous with cancer. A tumor can...

SureSeq Solid Tumour Panel Sequencing Service

The SureSeq Solid Tumour Panel Sequencing Service utilises an enrichment panel comprising the full coding regions of 58 prioritised cancer genes. The aim of the panel is to improve cancer care by pr...

DNA-FISH Probes

Fluorescent in situ hybridization (FISH) is a sensitive and accurate technique that allows the detection of chromosome aberrations. In this method, a single-stranded fluorescent-labeled nucleic acid...

Riboflavin

Riboflavin, also known as vitamin B2, is an easily absorbed, water-soluble micronutrient with a key role in maintaining human health. Vitamin B2 is a water-soluble vitamin, one that cannot be stored...

Of enzymes and aging: Tryptophan metabolism plays key role in aging and age-related neurological diseases

(Medical Xpress)—In the battle against aging and age-related neurological diseases such as Parkinson's and Alzheimer's, a key factor has long appeared to be the toxicity of proteins which tend to ag...

Detection of different oxidation states of individual manganese porphyrins during their reaction with oxygen at a solid/liquid interface

A scanning tunnelling microscope has been used to image multistep chemical reactions at a solid/liquid interface with single-molecule resolution. On reacting Mn(III) porphyrins with either O2 or a sin...

Ross SLIM system keeps solid-liquid mixes moving

The Solids/Liquid Injection Manifold (SLIM) technology is based on a modified rotor/stator mixer designed to generate a powerful vacuum

Thiostrepton tryptophan methyltransferase expands the chemistry of radical SAM enzymes

Methylation is among the most widespread chemical modifications encountered in biomolecules and has a pivotal role in many major biological processes. In the biosynthetic pathway of the antibiotic thi...

AAPS PharmSciTech: Nano-extrusion: a One-Step Process for Manufacturing of Solid Nanoparticle Formulations Directly from the Liquid Phase

Type: Brief CommunicationThis paper presents a novel one-step process for converting a liquid stabilized nano-suspension into a solid formulation via hot-melt extrusion combined with an internal devol...

Messy experiment cleans up physics mystery of cornstarch

Cornstarch, when mixed with water, forms a liquid that behaves in surprising ways, instantaneously turning into a solid under the force of a sudden impact. It’s soupy, yet adults can run across a...

Cytochrome P450–catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis

Thaxtomin phytotoxins produced by plant-pathogenic Streptomyces species contain a nitro group that is essential for phytotoxicity. The N,N′-dimethyldiketopiperazine core of thaxtomins is assembled f...

Autism discovery paves way for early blood test and therapeutic options

(Greenwood Genetic Center) Greenwood Genetic Center reports cells from individuals with autism spectrum disorders showed significantly decreased metabolism of the amino acid L-tryptophan. The paper, p...

Knocking out analysis of tryptophan permeases in Escherichia coli for improving L-tryptophan production.

Three permeases, Mtr, TnaB, and AroP, are involved in the uptake of L-tryptophan in Escherichia coli. These permeases possess individual function for cell transportation and metabolism, and affect ext...

Characterization and application of a DNA aptamer binding to l-tryptophan.

DNA aptamers for specific recognition of l-tryptophan have been evolved by a SELEX (systematic evolution of ligands by exponential enrichment) technique. Truncation-mutation experiments suggest that a...

One-step of tryptophan attenuator inactivation and promoter swapping to improve the production of L-tryptophan in Escherichia coli.

ABSTRACT: BACKGROUND: L-tryptophan is an aromatic amino acid widely used in the food, chemical and pharmaceutical industries. In Escherichia coli, L-tryptophan is synthesized from phosphoenolpyruvate...

Liquid slip on a nanostructured surface.

We explored a liquid slip, referred to as the Navier slip, at liquid-solid interface. Such a slip is provoked by the physicochemical features of the liquid-solid system. The goal of this study was to...

Enantioselective separation and electrochemical sensing of d- and l-tryptophan at ultratrace level using molecularly imprinted micro-solid phase extraction fiber coupled with complementary molecularly imprinted polymer-fiber sensor.

Highly efficient enantioselective separation and quantitative recoveries of d- and l-tryptophan in aqueous and real samples can be achieved, with a monolithic molecularly imprinted polymeric fiber tha...