Search Results for "Ketamine Amitriptyline Cream Side Effects"
Original Source: Topical Amitriptyline and Ketamine Cream in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer
RATIONALE: Topical cream containing amitriptyline and ketamine may help relieve pain, numbness, tingling, and other symptoms of peripheral neuropathy. It is not yet known whether topical amitriptyline and ketamine cream is more effective than a placebo in treating peripheral neuropathy caused by chemotherapy. PURPOSE: This randomized phase III trial is studying the side effects and how well topical amitriptyline and ketamine cream work compared with a placebo in treating perip...
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Ketamine and Phencyclidine PCP
Verona’s lead drug, RPL554, is a dual phosphodiesterase (PDE) 3 and 4 inhibitor being developed as a novel treatment for chronic obstructive airways disease as COPD (chronic obstructive pulmon...
Kadcyla (ado-trastuzumab emtansine)
Kadcyla™ (ado-trastuzumab emtansine or T-DM1) for the treatment of people with HER2-positive metastatic breast cancer (mBC) who have received prior treatment with Herceptin® (trastuzumab)...
Although the human cytokines interleukin-2 (IL-2) and tumor necrosis factor (TNF) alpha are approved marketed for tumor therapy, their use is rather limited due to severe systemic side effects. Targ...
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Researchers study how ketamine reduces side effects of ECT in people with severe depression
The largest trial into the use of Electroconvulsive Therapy in the UK in more than 30 years will look into how the use of the Class C drug ketamine might reduce the side effects of ECT for those being...
A drug that works through the same brain mechanism as the fast-acting antidepressant ketamine briefly improved treatment-resistant patients' depression symptoms in minutes, with minimal untoward side...
Researchers look at therapeutic benefits of ketamine
The largest trial into the use of Electroconvulsive Therapy (ECT) in the UK in more than 30 years will look into how the use of the Class C drug ketamine might reduce the side effects of ECT for those...
EpiCept moving forward with pain, say Edison analysts
US drug developer EpiCept's (Nasdaq; EPCT) investment case is centered on finding a development partner for AmiKet (amitriptyline 4%, ketamine 2% cream), a product for chemotherapy-induced peripheral...
(Medical Xpress)—A drug that works through the same brain mechanism as the fast-acting antidepressant ketamine briefly improved treatment-resistant patients' depression symptoms in minutes, with min...
Ketamine a Viable Option for Severe Depression?
Basic research on ketamine's rapid antidepressant effects point to synaptic dysfunction in the brain's mood circuitry as a key player in depression, experts say. Medscape Medical News
Fast-Acting Antidepressant Speeds Through Trials
A new fast-acting depression treatment drug could radically alter current patient timeframes, which can currently extend into many weeks. Claimed by its developers to work in a similar way to ketamine...
Matching PubMed Articles
High Doses of Topical Amitriptyline in Neuropathic Pain: Two Cases and Literature Review.
Severe chronic neuropathic pain is a challenge to treat, and due to adverse effects of classical oral medication, optimal and effective dose levels are difficult to reach. Therefore, administratio...
We have demonstrated previously that the ketamine-induced discriminative stimulus effect is likely to reflect the phencyclidine-like psychotomimetic effects. Therefore, the present study was designed...
PURPOSE: We investigated the heat pain threshold (HPT) and temporal summation threshold (TST) before and after target-controlled infusion (TCI) of ketamine with an effect-site concentration (Ce) of 30...
Effects of co-administration of amitriptyline and fluoxetine on inhibitory avoidance in mice.
We have previously observed that, while the impairing effects of amitriptyline on inhibitory avoidance in mice are consistently observed, those of acute fluoxetine are negligible. Two experiments were...
Intravenous ketamine (0.5 mg/kg) produces robust, rapid and long-lasting antidepressant effects, but is unpractical. Sublingual administration of ketamine renders better bioavailability (∼30%) and...
