Search Results for "Ketamine Depression"
Original Source: Optimization of IV Ketamine for Treatment Resistant Depression
Existing treatments for major depressive disorder (MDD) generally take weeks to months to exert their maximal benefit. There is an urgent need to develop rapid-acting treatments for MDD. Ketamine, a high-affinity N-methyl-D-aspartate (NMDA) glutamate receptor antagonist, has been used as a standard intravenous (IV) anesthetic agent for many years in both pediatric and adult patients. Beyond its well-established role in anesthesia and pain management, there is emerging evidence...
Matching Channels
Ketamine and Phencyclidine PCP
Depression is a serious mental health condition, where sad feelings carry on for weeks or months and interfere with your life. The symptoms include feeling unhappy most of the time (but may feel a...
Major depression unipolar disorder
Seroquel, an atypical antipsychotic medication has annual sales of $3.1m (in 2009), and based on annual sales, ranks 5th in the world. It is produced by AstraZeneca Pharmaceuticals as a quetiapine f...
Matching News
Ketamine Associated With Rapid Antidepressant Effect In Largest Clinical Trial To Date
Patients with treatment-resistant major depression saw dramatic improvement in their illness after treatment with ketamine, an anesthetic, according to the largest ketamine clinical trial to-date led...
Patients with treatment-resistant depression benefit from ketamine
Patients with treatment-resistant major depression saw dramatic improvement in their illness after treatment with ketamine, an anesthetic, according to the largest ketamine clinical trial to-date led...
Ketamine a Viable Option for Severe Depression?
Basic research on ketamine's rapid antidepressant effects point to synaptic dysfunction in the brain's mood circuitry as a key player in depression, experts say. Medscape Medical News
Ketamine Relieves Depression Symptoms Within Hours
Small amounts of the drug ketamine can immediately relieve the symptoms of chronic depression, as well as those of treatment-resistant patients within a few hours, say Yale scientists. After a decades...
Researchers study how ketamine reduces side effects of ECT in people with severe depression
The largest trial into the use of Electroconvulsive Therapy in the UK in more than 30 years will look into how the use of the Class C drug ketamine might reduce the side effects of ECT for those being...
How ketamine vanquishes depression within hours
Many chronically depressed and treatment-resistant patients experience immediate relief from symptoms after taking small amounts of the drug ketamine. For [...]
Researchers look at therapeutic benefits of ketamine
The largest trial into the use of Electroconvulsive Therapy (ECT) in the UK in more than 30 years will look into how the use of the Class C drug ketamine might reduce the side effects of ECT for those...
Ketamine for Bipolar Depression
Evidence is accumulating for ketamine's acute antidepressant effect in biopolar as well as unipolar depression, but this short-term study did not address the risk for induction of mania and cycling....
Matching PubMed Articles
Ketamine as a Fast Acting Antidepressant: Current Knowledge and Open Questions.
Several recent studies have shown that a single intravenous subanesthetic dose of ketamine, a NMDA receptor antagonist, exerts rapid antidepressant effects in patients with treatment refractory mood d...
A growing body of evidence has suggested that the dysfunction of glutamatergic systems plays a pivotal role in major depressive disorder (MDD). In clinical studies, an N-methyl-d-aspartate receptor an...
PURPOSE: We investigated the heat pain threshold (HPT) and temporal summation threshold (TST) before and after target-controlled infusion (TCI) of ketamine with an effect-site concentration (Ce) of 30...
We have demonstrated previously that the ketamine-induced discriminative stimulus effect is likely to reflect the phencyclidine-like psychotomimetic effects. Therefore, the present study was designed...
mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists.
The rapid antidepressant response after ketamine administration in treatment-resistant depressed patients suggests a possible new approach for treating mood disorders compared to the weeks or months r...
