Cellular Kinetics

Immunocytokines

Although the human cytokines interleukin-2 (IL-2) and tumor necrosis factor (TNF) alpha are approved marketed for tumor therapy, their use is rather limited due to severe systemic side effects. Targ...

Clinical Trials Phase News

Clinical trials involving new drugs are commonly classified into four phases. Each phase of the drug approval process is treated as a separate clinical trial. The drug-development process will norma...

Cognitive Bias Modification (CBM)

Cognitive Bias Modification (CBM) is new psychiatric therapy; involving just a few 15-minute sessions and no drugs, discussion of feelings, or even a psychiatrist, it is described as a cognitive vac...

Rheumatology

Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Dictionary). It...

Bayer launches Kinetics for Drug Discovery initiative

German drugs major Bayer HealthCare, a unit of Bayer AG (BAYN: DE) and Leiden University of the Netherlands will coordinate a newly founded international consortium, dubbed "K4DD" (Kinetics for Drug D...

New treatment available for repeated occlusion of arteries

(HealthDay)—A new endovascular brachytherapy (EVBT) procedure using liquid beta-emitting rhenium-188 (Re-188) is safe and effective in preventing restenosis in people with long-segment femoropoplite...

AAPS PharmSciTech: Photodegradation of Fleroxacin Injection: II. Kinetics and Toxicological Evaluation

Type: Original PaperPhotodegradation kinetics of fleroxacin were investigated in different injections. Five commercial formulations were analyzed before and after irradiation by determining residual v...

Label-free measuring and mapping of binding kinetics of membrane proteins in single living cells

Many biological processes involve the binding of proteins to cell membrane receptors, making these proteins valuable disease biomarkers and therapeutic targets. A label-free plasmonic microscopy metho...

Proteomic and Functional Analyses of Protein–DNA Complexes During Gene Transfer

Lyfe Communications Increases Bandwidth Services at 17 Apartment Complexes

SALT LAKE CITY, Nov. 15, 2012 (GLOBE NEWSWIRE) -- Lyfe Communications, Inc. (OTCBB:LYFE), a technology leader in the development of next generation media services integrating TV, high-speed Internet...

Immunomedics Announces U.S. Patent for Hexavalent DOCK-AND-LOCK(TM) Complexes

MORRIS PLAINS, N.J., Jan. 8, 2013 (GLOBE NEWSWIRE) -- Immunomedics, Inc. (Nasdaq:IMMU), a biopharmaceutical company primarily focused on the development of monoclonal antibody-based products for the...

AAPS PharmSciTech: Cyclodextrin-Crosslinked Poly(Acrylic Acid): Adhesion and Controlled Release of Diflunisal and Fluconazole from Solid Dosage Forms

Type: Original PaperThe controlled release of diflunisal and fluconazole from tablets made of novel polymers, poly(acrylic acid) (PAA) crosslinked with either β-cyclodextrin (βCD) or hydroxypropyl-Î...

Tuning the Reactivity in Classic Low-Spin d(6) Rhenium(I) Tricarbonyl Radiopharmaceutical Synthon by Selective Bidentate Ligand Variation (L,L'-Bid; L,L'= N,N', N,O, and O,O' Donor Atom Sets) in fac-Re(CO)(3)(L,L'-Bid)(MeOH)(n) Complexes.

Photoluminescence Electron-Transfer Quenching of Rhenium(I) Complexes with Organic Sulfides.

Electron-transfer(ET) from organic sulfides to excited state rhenium(I)-based heteroleptic tricarbonyl complexes [Re(bpy)(CO)(3)(py)](+) (I) and [Re(bpy)(CO)(3)(ind))](+) (II) in acetonitrile solution...

Photoswitching tetranuclear rhenium(i) tricarbonyl diimine complexes with a stilbene-like bridging ligand.

Highly efficient photoswitching tetranuclear rhenium(i) tricarbonyl diimine complexes with a stilbene-like bridging ligand are reported. The ability to directly populate excited states localized on th...

Mechanisms for CO Production from CO(2) Using Reduced Rhenium Tricarbonyl Catalysts.

The chemical conversion of CO(2) has been studied by numerous experimental groups. Particularly the use of rhenium tricarbonyl-based molecular catalysts has attracted interest owing to their ability t...

Targeting the estrogen receptor with metal-carbonyl derivatives of estradiol.

As part of our program to develop new probes for the estrogen receptor binding domain, we prepared and evaluated a novel 17α-(rhenium tricarbonyl bipyridyl) vinyl estradiol complex. Preparation of th...