Search Results for "Kynurenine Nrf2"
Original Source: Activation of the transcription factor Nrf2 in macrophages, Caco-2 cells and intact human gut tissue by Maillard reaction products and coffee.
In addition to direct antioxidative effects, Maillard reaction products (MRPs) could increase the antioxidative capacity of cells through the induction of cytoprotective enzymes. Since many of those enzymes are regulated by the transcription factor Nrf2, the effect of MRPs on nuclear translocation of Nrf2 in macrophages and Caco-2 cells was investigated. Stimulation of both cell types by MRPs showed a concentration-dependent significant increase in nuclear translocation of Nrf2 up to fivefold after short-te...
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NRF2 and cancer: the good, the bad and the importance of context
NFE2-related factor 2 (NRF2) has apparently contradictory roles in cancer. Activation of NRF2 contributes to the chemopreventive effects of various clinically used drugs against various diseases inclu...
Nrf2 regulates haematopoietic stem cell function
Van den Brink and colleagues show that Nrf2, a regulator of the oxidative stress response, is required for several aspects of haematopoietic stem cell maintenance. Loss of Nrf2 results in the hyper-pr...
Kynurenines in the CNS: recent advances and new questions
Most metabolites of the kynurenine pathway — which metabolizes tryptophan — are neuroactive. This Review describes the role of the kynurenine pathway in the pathology of Huntington's disease, migr...
Structural basis of kynurenine 3-monooxygenase inhibition
Inhibition of kynurenine 3-monooxygenase (KMO), an enzyme in the eukaryotic tryptophan catabolic pathway (that is, kynurenine pathway), leads to amelioration of Huntington’s-disease-relevant phenoty...
Denver Company Introduces Powerful New Antiaging Supplement, Nuley NRF2 Optimizer
A Denver company releases a new NRF2 activating natural supplement call Nuley NRF2 Optimizer. Nuley will be competing with other popular NRF2 activators such as Protandim in the competitive anti-aging...
Type: Original Paper3,3′-diindolylmethane (DIM) is currently being investigated in many clinical trials including prostate, breast, and cervical cancers and has been shown to possess anticancer effe...
LifeVantage Launches Protandim, the Nrf2 Synergizer in Japan
SALT LAKE CITY, Jan. 14, 2013 (GLOBE NEWSWIRE) -- LifeVantage Corporation (Nasdaq:LFVN), a company dedicated to helping people achieve healthy living through a combination of a compelling business op...
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Development of a fluorescent chemosensor for the detection of kynurenine.
Kynurenine, a metabolite of tryptophan, is known to contribute to cancer progression when overproduced. A method for facile fluorescent sensing of kynurenine using sensor 1 has been developed. When bo...
Preparation and photophysical properties of a caged kynurenine.
We have prepared l-kyurenine 4-hydroxyphenacyl ester, a caged derivative of l-kynurenine. N(α)-tBOC-l-tryptophan was reacted with 4-hydroxyphenacyl bromide in DMF with K(2)CO(3) as the base to give t...
NRF2 is a well-known, master transcription factor (TF) of oxidative and xenobiotic stress responses. Recent studies uncovered an even wider regulatory role of NRF2 influencing carcinogenesis, inflamma...
Th2 Skewing by Activation of Nrf2 in CD4+ T Cells.
NF erythroid 2-related factor 2 (Nrf2) is a transcription factor that mediates the upregulation of a battery of cytoprotective genes in response to cell stress. Recent studies showed that Nrf2 also mo...
MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism.
NF-E2-related factor 2 (Nrf2) is an important transcription factor involved in antioxidant response. Nrf2 binds antioxidant response elements (ARE) within promoters of genes encoding detoxification en...
