Colorectal Cancer

Colon or Colorectal cancer is the growth of malignant polyps on the colon, bowel, anus and rectum. Growths in these locations can be benign, and removed by colonoscopy, but they have a risk of becom...

Short Bowel Syndrome

Inflammatory Bowel Disease IBD

Bladder and bowel function

Irritable Bowel Syndrome IBS

Irritable bowel syndrome (IBS) is a common but poorly understood chronic (long-term) condition where the normal functions of the bowel are disrupted. Symptoms of IBS include abdominal pain or discom...

Protein arginine methyltransferases and cancer

Protein arginine methylation has various effects on cell signalling — targeting signalling proteins as well as histones — and the protein arginine methyltransferases (PRMTs) are altered in various...

News digest – bowel cancer increase, major NHS changes, Cancer Drugs Fund and more

April is bowel cancer awareness month, and new figures we released this week highlight the importance of the campaign. They show that bowel cancer rates among men have increased by more than a quarter...

Bowel Cancer Rates Increase In The UK

Over the last three and a half decades, the rate of bowel cancer among British men has increased by 30 percent while there's only been a 6 percent increase in women, according to Cancer Research UK....

News digest – bowel cancer news, HPV and cervical cancer, diesel fumes and dental hygiene

There’s a crop of stories about bowel cancer in the news this week, a couple of which have come from the National Cancer Intelligence Network (NCIN) conference, which took place on Thursday and Frid...

The FUS about arginine methylation in ALS and FTLD

Changes in arginine methylation are linked to the pathogenesis of the two neurodegenerative syndromes amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), yet methylation...

UK's Low Bowel Cancer Survival Likely Due To Differences In Staging And Treatment

Incomplete diagnostic investigation and failure to get the best treatment are the most likely reasons why survival for bowel cancer patients is lower in the UK than in other comparable countries, acco...

Novel Technology To Identify Biomarkers For Ulcerative Colitis

Scientists from the Florida campus of The Scripps Research Institute have developed a novel technology that can identify, in animal models, potential biomarkers of ulcerative colitis, a type of inflam...

Breast cancer gene provides vital clue to bowel cancer drug resistance

Having too many copies of a gene linked to breast cancer might be the reason why some bowel cancer patients fail to respond to certain targeted drugs, according to a study published in the British Jou...

Cancer cell sensitivity to arginine deprivation in vitro is not determined by endogenous levels of arginine metabolic enzymes.

Single amino acid arginine deprivation is currently considered as a therapeutic approach to treat certain types of tumors; the molecular mechanisms that underlie tumor cell sensitivity or resistance t...

Reproductive history and risk of small bowel cancer by histologic type: a population-based study.

PURPOSE: The male predominance of the two main histologic malignancies of the small bowel cancer may reflect a role of sex hormones which will be examined in this study. METHODS: This was a nationwide...

Canavanine augments proapoptotic effects of arginine deprivation in cultured human cancer cells.

Arginine deprivation achieved by means of recombinant arginine-degrading enzymes is currently being developed as a novel anticancer enzymotherapy. In this study, we showed that arginine deprivation in...

Cells derived from normal or cancer breast tissue exhibit different growth properties when deprived of arginine.

Arginine deprivation impairs cell proliferation more strong in cancer than in normal cells; thus, it has been proposed that such an effect could be exploited for cancer therapy. We have compared the e...

Protein arginine methyltransferases and cancer.

There are nine protein arginine methyltransferases (PRMTs) encoded in mammalian genomes, the protein products of which catalyse three types of arginine methylation - monomethylation and two types of d...