Insulin

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Protein arginine methyltransferases and cancer

Protein arginine methylation has various effects on cell signalling — targeting signalling proteins as well as histones — and the protein arginine methyltransferases (PRMTs) are altered in various...

The FUS about arginine methylation in ALS and FTLD

Changes in arginine methylation are linked to the pathogenesis of the two neurodegenerative syndromes amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), yet methylation...

Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation

Protein arginine methylation of the recently identified c-Jun coactivator protein RACO-1 establishes PRMT1 as new regulator of c-Jun/AP-1 function.

Diet Enriched With Arginine And Proline May Speed Wound Healing In Diabetes

Chronic wounds such as foot ulcers are a common problem for diabetics and are the cause of more than 80 percent of the lower leg amputations in these patients. There is currently no effective way to i...

Direct link ID'd for sleep deprivation, insulin sensitivity

(HealthDay)—Even short-term sleep restriction results in an insulin-resistant state in adipocytes, according to research published in the Oct. 16 issue of the Annals of Internal Medicine.

FDA to discuss Novo's insulin products

FDA confirmed the Nov. 8 meeting date for the Endocrinologic and Metabolic Drugs Advisory Committee to discuss NDAs from Novo Nordisk A/S (CSE:NVO; NYSE:NVO) for insulin Degludec and insulin Degludec/...

Structure of the TatC core of the twin-arginine protein transport system

The twin-arginine translocation (Tat) pathway transports folded proteins across membranes in bacteria and plant chloroplasts; the crystal structure of TatC, an integral membrane protein and core compo...

Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance

TRIP-Br2–null mice are resistant to obesity and insulin resistance and have higher energy expenditure because of increased thermogenesis and oxidative metabolism. As expression of this transcription...

Site-directed mutagenesis and feedback-resistant N-acetyl-L: -glutamate kinase (NAGK) increase Corynebacterium crenatum L: -arginine production.

N-Acetyl-L: -glutamate kinase (EC 2.7.2.8) is first committed in the specific L: -arginine pathway of Corynebacterium sp. A limited increase of L: -arginine production for the argB overexpression in t...

The L: -α-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L: -arginine-induced insulin release.

GPRC6A is a seven-transmembrane receptor activated by a wide range of L: -α-amino acids, most potently by L: -arginine and other basic amino acids. The receptor is broadly expressed, but its exact ph...

Insulin Responses to Administrations of Amino Acids and Fatty Acids in Healthy Cats.

In order to compare the stimulation ability of insulin secretion, we determined changes in plasma glucose and insulin concentrations after intravenous administration of various amino acids and essenti...

The arginine and GHRP-2 tests as alternatives to the insulin tolerance test for the diagnosis of adult GH deficiency in Japanese patients: A comparison.

The arginine + GHRH test has been established as an alternative to the insulin tolerance test (ITT) for the diagnosis of adult GH deficiency (AGHD). However, the glucagon, arginine, and GHRP-2 tests a...

Postprandial whole-body glycolysis is similar in insulin-resistant and insulin-sensitive non-diabetic humans.

AIMS/HYPOTHESIS: Insulin resistance is characterised by impaired glucose utilisation when measured by a euglycaemic-hyperinsulinaemic clamp. We hypothesised that, in response to...