Risk Factors

Surgical risk factors

Tissue Growth Factors BMP 2

The classical tissue factors typically are proteins used for tissue repair and growth stimulation. Among the approved products are the growth factors PDGF, IGF, EGF, BMP and FGF. One of the commercial...

Stroke CVA

A stroke is a cerebrovascular accident that results in inadequate blood flow to part of the brain, starving it of oxygen and causing immediate and irreversible changes to the neurones. If affects 15...

Plavix

Plavix is a clot-busting drug, produced by Bristol-Myers Squibb Company, and reached annual sales in 2009 of $4.2m, making the third highest drug in the world (based on 2009 annual sales). Prescri...

Inflammasome-derived IL-1β production induces nitric oxide–mediated resistance to Leishmania

Activation of inflammasomes has been implicated in sensing pathogens. Now Dario Zamboni and colleagues report that the Nlrp3 inflammasome has a key role in restricting replication of Leishmania parasi...

Leishmania mexicana metacaspase is a negative regulator of amastigote proliferation in mammalian cells

Veterinary medicine European Public Assessment Report (EPAR): CaniLeish, Leishmania infantum excreted secreted proteins (ESP), Revision: 1, Authorised

Immunity to Sand Fly Salivary Protein LJM11 Modulates Host Response to Vector-Transmitted Leishmania Conferring Ulcer-Free Protection

Veterinary medicine European Public Assessment Report (EPAR): CaniLeish, Leishmania infantum excreted secreted proteins, Revision: 1, Authorised

Apoptosis-like programmed cell death induces antisense ribosomal RNA (rRNA) fragmentation and rRNA degradation in Leishmania

Men with certain cardiovascular risk factors may be at increased risk of peripheral artery disease

Among nearly 45,000 men who were followed up for more than two decades, those with the risk factors of smoking, hypertension, high cholesterol, and type 2 diabetes had an associated greater risk of de...

Local Antimony Shots Effective Against Cutaneous Leishmaniasis

Intralesional injections of antimony are significantly more effective than cryotherapy or placebo in dealing with single lesions caused by Bolivian Leishmania (Viannia) braziliensis. Reuters Health...

Performance of commercially available serological diagnostic tests to detect Leishmania infantum infection on experimentally infected dogs.

Leishmania infantum (syn. Leishmania chagasi) is the etiological agent of a widespread serious zoonotic disease that affects both humans and dogs. Prevalence and incidence of the canine infection are...

A Serological and Molecular Study of Leishmania infantum Infection in Cats from the Island of Ibiza (Spain).

Abstract The aim of this study was to evaluate the prevalence of Leishmania infantum infection within a feline population by serologic and molecular methods and to identify associated risk factors. On...

First clinical case of cutaneous leishmaniasis due to Leishmania (Viannia) braziliensis in a domestic cat from French Guiana.

We report the first case of natural infection of a domestic female cat (Felis catus) by Leishmania (Viannia) braziliensis in French Guiana. The infected animal had a cutaneous ulcer on the nose and no...

Leishmania-induced repression of selected non-coding RNA genes containing B-box element at their promoters in alternatively polarized M2 macrophages.

Leishmania is a group of parasitic protozoa that infect blood and tissue phagocytes including macrophages. We hypothesize that Leishmania is capable of establishing infection inside the macrophages be...

Characterization of Leishmania spp. causing cutaneous leishmaniasis in Manaus, Amazonas, Brazil.

In the State of Amazonas, American tegumentary leishmaniasis is endemic and presents a wide spectrum of clinical variability due to the large diversity of circulating species in the region. Isolates f...