Search Results for "Leukemia Cells Rely On Glycolysis"
Original Source: Energy metabolism of leukemia cells: glycolysis versus oxidative phosphorylation.
For generation of energy, cancer cells utilize glycolysis more vigorously than oxidative phosphorylation in mitochondria (Warburg effect). We examined the energy metabolism of four leukemia cell lines by using glycolysis inhibitor, 2-deoxy-d-glucose (2-DG) and inhibitor of oxidative phosphorylation, oligomycin. NB4 was relatively sensitive to 2-DG (IC(50): 5.75 mM), consumed more glucose and produced more lactate (waste product of glycolysis) than the three other cell lines. Consequently, NB4 was consider...
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Chronic leukemia is a long term increase of abnormal white blood cells. It can be classed as myelogenous or lymphocytic leukemia. For more information see the Leukemia pages Add the Leukemia New...
Acute Lymphocytic Leukemia ALL
Acute lymphocytic leukemia (ALL) is a life-threatening disease in which the cells that normally develop into lymphocytes become cancerous and rapidly replace normal cells in the bone marrow. ALL acc...
Acute leukemia occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity. These lymphocytes (acute lymphocytic leukemia...
Chronic Myelocytic Leukemia CML
Chronic myelocytic leukemia is the resulting disease when neutrophil, basophil, eosinophil, and monocyte progenitors become cancerous. It is usually caused by the presence of the Philadelphia chromo...
Acute myelocytic leukemia is a life-threatening disease in which the neutrophil, basophil, eosinophil, and monocyte precursors become cancerous and rapidly replace normal cells in the bone marrow....
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Metabolic gatekeeper provides new target for disrupting cancer metabolism
In the 1920s, the German physiologist Otto Warburg proposed that cancer cells generate energy in ways that are distinct from normal cells. Healthy cells mainly metabolize sugar via respiration in the...
Protein controlling glucose metabolism also a tumor suppressor
A protein known to regulate how cells process glucose also appears to be a tumor suppressor, adding to the potential that therapies directed at cellular metabolism may help suppress tumor growth. In t...
The guardian: metabolic and tumour-suppressive effects of SIRT6
Cancer cells produce energy by increasing aerobic glycolysis instead of oxidative metabolism. SIRT6, a member of the sirtuins NAD+-dependent deacetylase family, has been shown to be involved in multip...
NOTCH1 signaling promotes T-cell acute lymphoblastic leukemia-initiating cell regeneration
Research suggests that patients with leukemia sometimes relapse because standard chemotherapy fails to kill the self-renewing leukemia initiating cells, often referred to as cancer stem cells. In such...
Japan Researchers Destroy Adult Leukemia Stem Cells In Animal Trial
Japan scientists report success in destroying stem cells believed responsible for an adult type of leukemia, acute myelogenous leukemia.
T-cell therapy eradicates an aggressive leukemia in 2 children
(University of Pennsylvania School of Medicine) Two children with an aggressive form of childhood leukemia had a complete remission of their disease -- showing no evidence of cancer cells in their bod...
Blocking Pathway To T-Cell Acute Lymphoblastic Leukemia-Initiating Cell Regeneration
Research suggests that patients with leukemia sometimes relapse because standard chemotherapy fails to kill the self-renewing leukemia initiating cells, often referred to as cancer stem cells. In such...
Matching PubMed Articles
Energy metabolism of leukemia cells: glycolysis versus oxidative phosphorylation.
For generation of energy, cancer cells utilize glycolysis more vigorously than oxidative phosphorylation in mitochondria (Warburg effect). We examined the energy metabolism of four leukemia cell lines...
Background/Aims:By reducing the number of ATP molecules produced via aerobic glycolysis, the inhibition of lactic dehydrogenase (LDH) should hinder the growth of neoplastic cells without damaging the...
Aerobic glycolysis: meeting the metabolic requirements of cell proliferation.
Warburg's observation that cancer cells exhibit a high rate of glycolysis even in the presence of oxygen (aerobic glycolysis) sparked debate over the role of glycolysis in normal and cancer cells. Alt...
Mitochondrial Metabolism Inhibitors for Cancer Therapy.
Cancer cells catabolise nutrients in a different way than healthy cells. Healthy cells mainly rely on oxidative phosphorylation, while cancer cells employ aerobic glycolysis. Glucose is the main nutri...
