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Linezolid packs a punch against resistant TB in early trial

Linezolid is effective against extensively drug resistant tuberculosis, according to a paper published online...

Linezolid Treats XDR Tuberculosis, but Is It Too Toxic?

Linezolid may effectively treat patients with chronic, extremely drug-resistant tuberculosis after chemotherapy fails, but the treatment is associated with severe adverse effects. Medscape Medical...

Antibiotics for Skin Infections New Study Design and a Step Toward Shorter Course Therapy Antibiotics for Skin Infections

In this issue of JAMA, Prokocimer et al present the results of ESTABLISH-1 (Efficacy and Safety of 6-day Oral Tedizolid in Acute Bacterial Skin and Skin Structure Infections vs 10-day Oral Linezolid T...

Resistance (To Resistance) Is Futile: The Growing Opportunity For Trius And Tedizolid

By David Sobek:Jason Napodano, CFA & Aafia Chaudhry, MD, recently wrote a nice article discussing some of the flaws in the current bear thesis on Trius Therapeutics (TSRX). One of the bear theses...

Trius: The Winner In The War Against MRSA

BySuresh Gupta:MRSA (Methicillin-resistant Staphylococcus aureus) infects through an open wound and results in lesions and boils. It is resistant to conventional antibiotics, and if it gets into your...

Tedizolid Phosphate vs Linezolid for Treatment of Acute Bacterial Skin and Skin Structure Infections The ESTABLISH-1 Randomized Trial Treatment of Skin and Skin Structure Infections

ImportanceAcute bacterial skin and skin structure infections (ABSSSIs), including cellulitis or erysipelas, major cutaneous abscesses, and wound infections, can be life-threatening and may require sur...

Important Therapeutic Option Shows Promise In Treating Extensively Drug-Resistant Tuberculosis

When tested in patients hospitalized with extensively drug-resistant tuberculosis (XDR-TB) unresponsive to previous treatment, linezolid, an antibiotic used to treat severe bacterial infections, prove...

Antibiotic shows promise in treating extensively drug-resistant tuberculosis

When tested in patients hospitalized with extensively drug-resistant tuberculosis (XDR-TB) unresponsive to previous treatment, linezolid, an antibiotic used to treat severe bacterial infections, prove...

Molecular analysis of linezolid resistance in clinical Enterococcus faecium isolates by polymerase chain reaction and pyrosequencing.

Resistance to linezolid has been associated with a G2576T mutation in the 23 S rRNA gene. Clinical isolates of linezolid-sensitive and linezolid-resistant vancomycin-resistant Enterococcus faecium of...

Immediate hematological toxicity of linezolid in healthy volunteers with different body weight: a phase I clinical trial.

Linezolid is an important therapeutic option for infections from multi-drug resistant Gram-positive pathogens. However, prolonged linezolid treatment (>14 days) is considered to increase the risk of h...

Tolerability of prolonged linezolid therapy in bone and joint infection: protective effect of rifampicin on the occurrence of anaemia?

Background Linezolid therapy has shown high rates of clinical success in patients with osteomyelitis and prosthetic joint infections caused by Gram-positive cocci. Recent studies have demonstrated tha...

Chronic liver disease increases the risk of linezolid-related thrombocytopenia in methicillin-resistant Staphylococcus aureus-infected patients after digestive surgery.

Linezolid is an effective antibiotic for treatment of infections caused by resistant Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). However, thrombocytopenia has...

Black tongue associated with linezolid.

Darkening of the tongue and oral mucosa is a reaction pattern that can be related to a number of physiologic, metabolic, and toxic disorders, and medications and exogenous substances. Black discolorat...