Hedgehog signalling cascades

Despite the humorous name, hedgehog signalling cascades are central to embryonic development and has been implicated in the development of a number of diseases, including cancer. The downstream ca...

Serine Threonine protein kinase C PKC

The serine/threonine protein kinase C (PKC) family consists of at least 11 mammalian isozymes belonging to a larger subclass of protein kinases termed the adenine-guanine-cytosine (AGC) kinases. PK...

TASH Biotechnology

Shanghai TASH Biotechnology Co.,Ltd. specializes in peptide development on the basis of high technology. TASH Biotechnology are focusing on custom peptide synthesis, and the research, development...

Wnt is an anti-apoptotic ligand for the Fz (frizzled) receptor on cell membranes

Wnt is an anti-apoptotic ligand for the Fz (frizzled) receptor on cell membranes, meaning it attaches to the Fz receptor and prevents cell death (in effect with other cellular stimuli). Wnt molecule...

Mutation location is the key to prognosis

The three most important factors in real estate are location, location, location, and the same might be said for mutations in the gene MECP2, said researchers at Baylor College of Medicine and the Jan...

Location-Based Mobile Apps Case Study: Harnessing Location-Aware Technology in CPG Mobile Marketing

Introduction Despite greater usage of location-aware technology, the uptake of both social location-sharing services and location-based shopping apps in CPG marketing has been behind the curve compare...

Location, Location, Location: St. Louis-Based Digital Marketing Firm Makes Local Search Optimization Easy and Affordable for SMBs With New Service Offering

ST. LOUIS, March 25, 2013 (GLOBE NEWSWIRE) -- St. Louis-based digital marketing firm, tSunela, introduces to market an affordable local search optimization package that helps small-to mid-size busine...

Breaking down the list of biopharma's most influential

Leaders of big drugmakers, including Sanofi, Roche and GlaxoSmithKline, make up the biggest contingent in the FiercePharma li -More- Gene Location Affects Properties, Impacts on Regulatory P...

Pie Five Pizza Co. Opens Seventh Location and First College Location at University of Texas at Arlington

THE COLONY, Texas, Aug. 27, 2012 (GLOBE NEWSWIRE) -- The new kid on the block is growing up and going to college. Today, Pie Five Pizza Co., which landed on the fast-casual restaurant scene last year...

Location, location, location: Membrane 'residence' gives proteases novel abilities

(Johns Hopkins Medicine) Johns Hopkins scientists have discovered a new mode of action for enzymes immersed in cellular membranes. Their experiments suggest that instead of recognizing and clipping pr...

Norwegian Researchers Discover Surprising Complexities In The Way The Brain Makes Mental Maps

Your brain has at least four different senses of location - and perhaps as many as 10. And each is different, according to new research from the Kavli Institute for Systems Neuroscience, at the Norweg...

Multipurpose Smartphone App Can Track Objects On The Battlefield As Well As On The Sports Field

University of Missouri researchers have developed new software using smartphones' GPS and imaging abilities that determine the exact location of distant objects as well as monitor the speed and direct...

Inducing toxicity by introducing a leucine zipper like motif in frog antimicrobial peptide, magainin 2.

Cytotoxicity, a major obstacle in therapeutic application of antimicrobial peptides, is controlled by leucine zipper like sequences in melittin and other naturally-occurring antimicrobial peptides. Ma...

Kinetic pathway of antimicrobial peptide magainin 2-induced pore formation in lipid membranes.

The pore formation in lipid membranes induced by the antimicrobial peptide magainin 2 is considered to be the main cause for its bactericidal activity. To reveal the mechanism of the pore formation, i...

Lipid-Controlled Peptide Topology and Interactions in Bilayers: Structural Insights into the Synergistic Enhancement of the Antimicrobial Activities of PGLa and Magainin 2.

To gain further insight into the antimicrobial activities of cationic linear peptides, we investigated the topology of each of two peptides, PGLa and magainin 2, in oriented phospholipid bilayers in t...

Difference between Magainin-2 and Melittin Assemblies in Phosphatidylcholine Bilayers: Results from Coarse-Grained Simulations.

We performed coarse-grained computer simulations using MARTINI force field to study the difference in the self-assembly and possible pore creation in DPPC phospholipid membranes by two different antim...

Enhancement of cytotoxicity of antimicrobial peptide magainin II in tumor cells by bombesin-targeted delivery.

Aim:To investigate whether the conjugation of magainin II (MG2), an antimicrobial peptides (AMPs), to the tumor-homing peptide bombesin could enhance its cytotoxicity in tumor cells.Methods:A magainin...