Substance Use in Children and Adolescents

Screening and diagnosis of children and adults

Obstructive Sleep Apnea in Children

Hypopituitarism in Children Resulting in Short Stature

Somatropin Hgh rDNA Pfizer

What is GENOTROPIN? GENOTROPIN (somatropin [rDNA origin] for injection) is a growth hormone treatment. It is an exact copy of the natural growth hormone that our bodies make. The main difference i...

Pharmaceutical Research: Freeze-Dried Mannitol for Superior Pulmonary Drug Delivery via Dry Powder Inhaler

Type: Original PaperPurposeTo show for the first time the superior dry powder inhaler (DPI) performance of freeze dried mannitol in comparison to spray dried mannitol and commercial mannitol.MethodsDi...

Mannitol Offers Sweet Future For Parkinson's Disease

Researchers from Tel Aviv University describe experiments that could lead to a new approach for treating Parkinson's disease (PD) using a common sweetener, mannitol. This research was presented at the...

Pharmaceutical Research: Influence of Process Conditions on the Crystallization and Transition of Metastable Mannitol Forms in Protein Formulations During Lyophilization

Type: Original PaperPurposeTo study the impact of different process conditions and formulation compositions on metastable mannitol forms in protein formulations during lyophilization.MethodsMannitol w...

Pharmaxis seeks US FDA OK for inhaled mannitol in CF

Australian specialty drug maker Pharmaxis submitted a new drug application (NDA) to the US FDA for Bronchitol, a formulation of mannitol administered as a dry powder in a hand‐held inhaler, as...

Pharmaceutical Research: Brain Extracellular γ-hydroxybutyrate Concentrations are Decreased by L-lactate in Rats: Role in the Treatment of Overdoses

Type: Original PaperPurposeL-lactate represents a potential treatment for GHB overdose by inhibiting GHB renal reabsorption mediated by monocarboxylate transporters. Our objective was to assess the do...

US FDA panel slams door on Pharmaxis dry-powder mannitol in CF

A panel of 14 expert advisers to the US FDA on 30 January was unanimous in declaring Pharmaxis' efficacy and safety data had failed to provide substantial evidence to support approval of the Australi...

FDA to review Bronchitol for CF

FDA accepted for review an NDA from Pharmaxis Ltd. (ASX:PXS; Pink:PXSLY) for Bronchitol mannitol to treat cystic fibrosis (CF) in patients six years of age or older to improve pulmonary function. The...

Mannitol could lead to new approach for Parkinson's disease treatment, researchers suggest

Researchers from Tel Aviv University describe experiments that could lead to a new approach for treating Parkinson's disease using a common sweetener, mannitol.

Biotechnological production of mannitol and its applications.

Mannitol, a naturally occurring polyol (sugar alcohol), is widely used in the food, pharmaceutical, medical, and chemical industries. The production of mannitol by fermentation has become attractive b...

Cloning and molecular analysis of a mannitol operon of phosphoenolpyruvate-dependent phosphotransferase (PTS) type from Vibrio cholerae O395.

A putative mannitol operon of the phosphoenolpyruvate phosphotransferase (PTS) type was cloned from Vibrio cholerae O395, and its activity was studied in Escherichia coli. The 3.9-kb operon comprising...

Modern approach for determination of lactulose, mannitol and sucrose in human urine using HPLC-MS/MS for the studies of intestinal and upper digestive tract permeability.

A new analytical procedure was described for the simultaneous determination of lactulose, mannitol and sucrose in urine, in which HILIC chromatography and tandem mass spectrometry detection are used....

Lactobacillus reuteri CRL 1101 highly produces mannitol from sugarcane molasses as carbon source.

Mannitol is a natural polyol extensively used in the food industry as low-calorie sugar being applicable for diabetic food products. We aimed to evaluate mannitol production by Lactobacillus reuteri C...

Mannitol permeation and radial flow of water in maize roots.

• The postulated nonselective hydraulic route through the root apoplast has not yet been supported by experimental findings on solvent drag. • Therefore, mannitol transport from the medium to the...