Search Results for "Mannitol In Copd"
Original Source: Airway inflammation and mannitol challenge test in COPD.
ABSTRACT: BACKGROUND: Eosinophilic airway inflammation has successfully been used to tailor anti-inflammatory therapy in chronic obstructive pulmonary disease (COPD). Airway hyperresponsiveness (AHR) by indirect challenges is associated with airway inflammation. We hypothesized that AHR to inhaled mannitol captures eosinophilia in induced sputum in COPD. METHODS: Twenty-eight patients (age 58+/-7.8 yr, packyears 40+/-15.5, post-bronchodilator FEV1 77+/-14.0 %predicted, no inhaled steroids [greater than or e...
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COPD (chronic obstructive pulmonary disease) is used for a number of conditions including chronic bronchitis and emphysema, which all lead to the airways in the lungs becoming damaged and thus...
Treatment of Acute COPD Exacerbation
Verona’s lead drug, RPL554, is a dual phosphodiesterase (PDE) 3 and 4 inhibitor being developed as a novel treatment for chronic obstructive airways disease as COPD (chronic obstructive pulmon...
Neutrophil elastase (NE) is a serine protease, expressed mainly by neutrophils, that is capable of degrading a variety of structural proteins of the extracellular matrix. Infiltration of activated n...
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Type: Original PaperPurposeTo show for the first time the superior dry powder inhaler (DPI) performance of freeze dried mannitol in comparison to spray dried mannitol and commercial mannitol.MethodsDi...
Mannitol Offers Sweet Future For Parkinson's Disease
Researchers from Tel Aviv University describe experiments that could lead to a new approach for treating Parkinson's disease (PD) using a common sweetener, mannitol. This research was presented at the...
Type: Original PaperPurposeTo study the impact of different process conditions and formulation compositions on metastable mannitol forms in protein formulations during lyophilization.MethodsMannitol w...
Type: Original PaperPurposeL-lactate represents a potential treatment for GHB overdose by inhibiting GHB renal reabsorption mediated by monocarboxylate transporters. Our objective was to assess the do...
FDA to discuss pulmonary compounds
FDA's Pulmonary-Allergy Drugs Advisory Committee will meet on Jan. 29, 2013 to discuss an NDA from Boehringer Ingelheim GmbH (Ingelheim, Germany) for Striverdi Respimat olodaterol to treat airflow obs...
US FDA panel slams door on Pharmaxis dry-powder mannitol in CF
A panel of 14 expert advisers to the US FDA on 30 January was unanimous in declaring Pharmaxis' efficacy and safety data had failed to provide substantial evidence to support approval of the Australi...
FDA to review Bronchitol for CF
FDA accepted for review an NDA from Pharmaxis Ltd. (ASX:PXS; Pink:PXSLY) for Bronchitol mannitol to treat cystic fibrosis (CF) in patients six years of age or older to improve pulmonary function. The...
Mannitol could lead to new approach for Parkinson's disease treatment, researchers suggest
Researchers from Tel Aviv University describe experiments that could lead to a new approach for treating Parkinson's disease using a common sweetener, mannitol.
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Airway inflammation and mannitol challenge test in COPD.
ABSTRACT: BACKGROUND: Eosinophilic airway inflammation has successfully been used to tailor anti-inflammatory therapy in chronic obstructive pulmonary disease (COPD). Airway hyperresponsiveness (AHR)...
Biotechnological production of mannitol and its applications.
Mannitol, a naturally occurring polyol (sugar alcohol), is widely used in the food, pharmaceutical, medical, and chemical industries. The production of mannitol by fermentation has become attractive b...
Insomnia in Patients with COPD.
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality and may frequently be associated with sleep disturbances. However, the correlates of insomnia in COPD patient...
A putative mannitol operon of the phosphoenolpyruvate phosphotransferase (PTS) type was cloned from Vibrio cholerae O395, and its activity was studied in Escherichia coli. The 3.9-kb operon comprising...
Lactobacillus reuteri CRL 1101 highly produces mannitol from sugarcane molasses as carbon source.
Mannitol is a natural polyol extensively used in the food industry as low-calorie sugar being applicable for diabetic food products. We aimed to evaluate mannitol production by Lactobacillus reuteri C...
