Search Results for "Melanin Ulk1"

00:36 EDT 3rd September 2014 | BioPortfolio

Original Source: GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.

In metazoans, cells depend on extracellular growth factors for energy homeostasis. We found that glycogen synthase kinase-3 (GSK3), when deinhibited by default in cells deprived of growth factors, activates acetyltransferase TIP60 through phosphorylating TIP60-Ser(86), which directly acetylates and stimulates the protein kinase ULK1, which is required for autophagy. Cells engineered to express TIP60(S86A) that cannot be phosphorylated by GSK3 could not undergo serum deprivation-induced autophagy. An acetyla...

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Blacks are not immune from sun-caused skin cancer

We all have melanin, which gives our skin pigmentation. But some of us - because of genetics and ethnicity - have more than others. In the past, it was believed the more melanin a person had, the less...

Eumelanin's secrets: Discovery of melanin structure may lead to better sun protection

Melanin -- and specifically, the form called eumelanin -- is the primary pigment that gives humans the coloring of their skin, hair, and eyes. It protects the body from the hazards of ultraviolet and ...

Understanding melanoma development

A new study shows how a genetic defect in a specific hormonal pathway may make people more susceptible to developing melanoma, the deadliest type of skin cancer. The study looked at the role of the me...

Melanoma Monday: The Global Footprint of Melanoma

To raise awareness on Melanoma Monday, Thomson Reuters has prepared a special infographic highlighting Melanoma’s global footprint. Our recent report, Spotlight On Melanoma, is also available to...

Environmental factors may explain some racial disparities in childbirth

A new study investigating racial disparities in birth outcomes shows that contrary to some theories Vitamin D is unlikely to play a role in differences in preterm birth and low birth weight between Af...

Vitamin D hypothesis challenged: Some racial disparities in childbirth more environmental than genetic

A new study investigating racial disparities in birth outcomes shows that contrary to some theories, vitamin D is unlikely to play a role in differences in preterm birth and low birth weight between A...

New Research Supports Massage as Supplemental Treatment for Low-Back Pain and Burn Scars

EVANSTON, Ill., May 13, 2014 /PRNewswire/ -- Two new independent clinical studies demonstrate that massage therapy eases pain and improves recovery time for people suffering from lower back injur...

High-factor sunscreen doesn’t cut melanoma risk

“High-factor sun cream cannot…protect against the deadliest form of skin cancer,” The Guardian reports. Research involving mice with a predisposition to develop melanoma found that sunscreen onl...

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Keratinocyte-derived laminin-332 promotes melanin synthesis via regulation of tyrosine uptake.

Melanocytes, which produce the pigment melanin, are known to be closely regulated by neighboring keratinocytes. However, how keratinocytes regulate melanin production is unclear. Here, we report that ...

ATG13: Just a companion, or an executor of the autophagic program?

During the past 20 years, autophagy signaling has entered the main stage of the cell biological theater. Autophagy represents an intracellular degradation process that is involved in both the bulk rec...

Evolutionary and biomedical consequences of internal melanins.

The adaptive function of melanin located in the integument is well known. Although pigments are also deposited in various internal organs, their function is unclear. A review of the literature reveale...

Inhibition of nitric oxide and tumour necrosis factor-α production in peritoneal macrophages by Aspergillus nidulans melanin.

The naturally occurring pigment, melanin is found in organisms of all phylogenetic kingdoms, including fungi, and exhibits a wide range of biological activities. Our objective was to investigate the e...

Inhibition of melanin content by Punicalagins in the super fruit pomegranate (Punica granatum).

Current efforts to develop effective skin lightening products through the inhibition of melanin production have focused on compounds that inhibit the function and activity of tyrosinase, the rate-limi...

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