Search Results for "Melanin Ulk1"

11:52 EST 27th January 2015 | BioPortfolio

Original Source: GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.

In metazoans, cells depend on extracellular growth factors for energy homeostasis. We found that glycogen synthase kinase-3 (GSK3), when deinhibited by default in cells deprived of growth factors, activates acetyltransferase TIP60 through phosphorylating TIP60-Ser(86), which directly acetylates and stimulates the protein kinase ULK1, which is required for autophagy. Cells engineered to express TIP60(S86A) that cannot be phosphorylated by GSK3 could not undergo serum deprivation-induced autophagy. An acetyla...

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ROS inhibit autophagy by downregulating ULK1 mediated by the phosphorylation of p53 in selenite-treated NB4 cells

Facial Pores in Melanin Layer and Genetic Algorithms for Human Face Characterization

Facial Pores in Melanin Layer and Genetic Algorithms for Human Face CharacterizationPages 12-21Author Carlos Villegas-QuezadaJoan ClimenAbstract The characterization of a face is a vital element for ...

New research unlocks a mystery of albinism

Newly published research provides the first demonstration of how a genetic mutation associated with a common form of albinism leads to the lack of melanin pigments that characterizes the condition.

Scientists finally discover molecular pathway behind albinism

Brett Smith for redOrbit.com - Your Universe Online Affecting 1 in 40,000 individuals, type 2 oculocutaneous albinism is a pigmentation condition in which an individual has unusually light skin, eye ...

Melanoma: Scientists find new link between pigment production, mitochondrial function

New research helps explain what goes wrong to when someone gets skin cancer and the relationship between changing skin pigment and the cancer itself. In particular, this research shows that there is a...

Drug targets identified through cell line to potentially treat rare pediatric cancer

A team of investigators at the Cumming School of Medicine have made key new findings about an extremely rare childhood cancer called neurocutaneous melanocytosis (NCM). This malignant cancer is charac...

Fleur’s Launches Brightening Cleansing Milk

A silky and extremely lightweight evanescent milk that enhances the skin’s natural brightness. SAINT-MALO, FRANCE (PRWEB) January 22, 2015 Fleur’s introduces Brightening Cleansing Milk, part of t...

Fleur’s Introduces Brightening Source Cream SPF15

A rich cream with a velvety finish that visibly illuminates the skin and reduces pigmentary imperfections. SAINT-MALO, FRANCE (PRWEB) January 25, 2015 Fleur’s introduces Brightening Source Cream, p...

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Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors.

Autophagy is a conserved cellular process that involves the degradation of cellular components for energy maintenance and cytoplasmic quality control that has recently gained interest as a novel targe...

Keratinocyte-derived laminin-332 promotes melanin synthesis via regulation of tyrosine uptake.

Melanocytes, which produce the pigment melanin, are known to be closely regulated by neighboring keratinocytes. However, how keratinocytes regulate melanin production is unclear. Here, we report that ...

ATG13: Just a companion, or an executor of the autophagic program?

During the past 20 years, autophagy signaling has entered the main stage of the cell biological theater. Autophagy represents an intracellular degradation process that is involved in both the bulk rec...

Evolutionary and biomedical consequences of internal melanins.

The adaptive function of melanin located in the integument is well known. Although pigments are also deposited in various internal organs, their function is unclear. A review of the literature reveale...

Dopamine-melanin nanofilms for biomimetic structural coloration.

This article describes the formation of dopamine-melanin thin films (50 - 200 nm thick) at an air/dopamine solution interface under static conditions. Beneath these films, spherical melanin granules f...

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