Search Results for "Melanin Ulk1"

09:54 EDT 1st August 2015 | BioPortfolio

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The Dark Side of Melanin

Researchers uncover a previously unknown way UV light can act on melanin, spurring cancer-causing mutations hours after sun exposure.

Chaperone-like protein p32 regulates ULK1 stability and autophagy

Nuclear ULK1 promotes cell death in response to oxidative stress through PARP1

Huntingtin functions as a scaffold for selective macroautophagy

Zhang, Cuervo and colleagues find that Huntingtin (Htt), which is commonly mutated in Huntington disease, regulates selective autophagy. Htt enhances interactions between p62, LC3 and ubiquitylated ca...

Week in Review: February 16?20

Epigenomes galore; one way marijuana affects appetite; anticipating antibiotic resistance; UV exposure, melanin, and harmful mutations

DNA Damage Continues Long After Sun Exposure

Experiments conducted in mouse and human cells suggest that UV radiation–induced DNA lesions can occur in melanin-producing cells more than 3 hours after sunbathing or tanning (Premi S et al. Scienc...

Global Melanoma Therapeutics Market 2015-2019

About Melanoma According to Melanoma Research Foundation, melanoma is usually, but not always, a cancer of the skin. Melanoma is defined as a cancer that occurs in melanocytes (cells that make the pig...

Biochemistry: Sunlight damages DNA in the dark

Sunlight can cause cancer-related DNA damage hours after light exposure, owing to a skin pigment that was largely thought to be protective.Douglas Brash at Yale University School of Medicine in New Ha...

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Pharmacological Inhibition of ULK1 Blocks mTOR-Dependent Autophagy.

Autophagy is a cell protective and degradative process that recycles damaged and long-lived cellular components. Cancer cells are thought to take advantage of autophagy to help them to cope with the s...

Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy.

Autophagy represents an intracellular degradation process which is involved in both regular cell homeostasis and disease settings. In recent years, the molecular machinery governing this process has b...

Chaperone-like protein p32 regulates ULK1 stability and autophagy.

Mitophagy mediates clearance of dysfunctional mitochondria, and represents one type of mitochondrial quality control, which is essential for optimal mitochondrial bioenergetics. p32, a chaperone-like ...

Chaperone-like protein p32 regulates ULK1 stability and autophagy.

Mitophagy mediates clearance of dysfunctional mitochondria, and represents one type of mitochondrial quality control, which is essential for optimal mitochondrial bioenergetics. p32, a chaperone-like ...

ULK1: A Promising Biomarker in Predicting Poor Prognosis and Therapeutic Response in Human Nasopharygeal Carcinoma.

Plenty of studies have established that dysregulation of autophagy plays an essential role in cancer progression. The autophagy-related proteins have been reported to be closely associated with human ...

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