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Search Results for "Melanin Ulk1"

08:43 EDT 23rd April 2014 | BioPortfolio

Original Source: GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.

In metazoans, cells depend on extracellular growth factors for energy homeostasis. We found that glycogen synthase kinase-3 (GSK3), when deinhibited by default in cells deprived of growth factors, activates acetyltransferase TIP60 through phosphorylating TIP60-Ser(86), which directly acetylates and stimulates the protein kinase ULK1, which is required for autophagy. Cells engineered to express TIP60(S86A) that cannot be phosphorylated by GSK3 could not undergo serum deprivation-induced autophagy. An acetyla...

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Rab11b Mediates Melanin Transfer between Donor Melanocytes and Acceptor Keratinocytes via Coupled Exo/Endocytosis

Docosahexaenoic acid inhibits melanin synthesis in murine melanoma cells in vitro through increasing tyrosinase degradation

Melanosome evolution indicates a key physiological shift within feathered dinosaurs

Inference of colour patterning in extinct dinosaurs has been based on the relationship between the morphology of melanin-containing organelles (melanosomes) and colour in extant bird feathers. When th...

The most common gene mutation in human pigmentation in the Mediterranean countries increases predisposition to skin cancer

When Homo sapiens left Africa and had to adapt to less sunny climates, there was a mutation in one of the genes responsible for regulating the synthesis of melanin, the MC1R gene, which involved a dis...

Most common gene mutation in human pigmentation in Mediterranean countries linked to increased skin cancer

When Homo sapiens left Africa and had to adapt to less sunny climates, there was a mutation in one of the genes responsible for regulating the synthesis of melanin, the MC1R gene, which involved a dis...

Environmental factors may explain some racial disparities in childbirth

A new study investigating racial disparities in birth outcomes shows that contrary to some theories Vitamin D is unlikely to play a role in differences in preterm birth and low birth weight between Af...

Vitamin D hypothesis challenged: Some racial disparities in childbirth more environmental than genetic

A new study investigating racial disparities in birth outcomes shows that contrary to some theories, vitamin D is unlikely to play a role in differences in preterm birth and low birth weight between A...

Mutation V60L increases predisposition to skin cancer

When Homo sapiens left Africa and had to adapt to less sunny climates, there was a mutation in one of the genes responsible for regulating the synthesis of melanin, the MC1R gene, which involved a dis...

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Inhibition of nitric oxide and tumour necrosis factor-α production in peritoneal macrophages by Aspergillus nidulans melanin.

The naturally occurring pigment, melanin is found in organisms of all phylogenetic kingdoms, including fungi, and exhibits a wide range of biological activities. Our objective was to investigate the e...

Inhibition of melanin content by Punicalagins in the super fruit pomegranate (Punica granatum).

Current efforts to develop effective skin lightening products through the inhibition of melanin production have focused on compounds that inhibit the function and activity of tyrosinase, the rate-limi...

Antifungal activity of melanin in clinical isolates of Candida spp.

Background: Melanocytes are cells located in epidermis and mucous membranes that synthesize melanin and cytokines. It is known that melanin has antimicrobial activity and that melanocytes are melanize...

Temozolomide induces autophagy via ATM‑AMPK‑ULK1 pathways in glioma.

Autophagy is a cytoprotective process, which occurs following temozolomide (TMZ) treatment, and contributes to glioma chemoresistance and TMZ treatment failure. However, the molecular mechanisms by wh...

Inducing self-rotation of cells with natural and artificial melanin in a linearly polarized alternating current electric field.

The phenomenon of self-rotation observed in naturally and artificially pigmented cells under an applied linearly polarized alternating current (non-rotating) electrical field has been investigated. Th...

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