Search Results for "Melanin Ulk1"

19:52 EST 22nd December 2014 | BioPortfolio

Original Source: GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.

In metazoans, cells depend on extracellular growth factors for energy homeostasis. We found that glycogen synthase kinase-3 (GSK3), when deinhibited by default in cells deprived of growth factors, activates acetyltransferase TIP60 through phosphorylating TIP60-Ser(86), which directly acetylates and stimulates the protein kinase ULK1, which is required for autophagy. Cells engineered to express TIP60(S86A) that cannot be phosphorylated by GSK3 could not undergo serum deprivation-induced autophagy. An acetyla...

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ROS inhibit autophagy by downregulating ULK1 mediated by the phosphorylation of p53 in selenite-treated NB4 cells

Understanding melanoma development

A new study shows how a genetic defect in a specific hormonal pathway may make people more susceptible to developing melanoma, the deadliest type of skin cancer. The study looked at the role of the me...

Facial Pores in Melanin Layer and Genetic Algorithms for Human Face Characterization

Facial Pores in Melanin Layer and Genetic Algorithms for Human Face CharacterizationPages 12-21Author Carlos Villegas-QuezadaJoan ClimenAbstract The characterization of a face is a vital element for ...

New research unlocks a mystery of albinism

Newly published research provides the first demonstration of how a genetic mutation associated with a common form of albinism leads to the lack of melanin pigments that characterizes the condition.

Scientists finally discover molecular pathway behind albinism

Brett Smith for redOrbit.com - Your Universe Online Affecting 1 in 40,000 individuals, type 2 oculocutaneous albinism is a pigmentation condition in which an individual has unusually light skin, eye ...

Transcriptional regulation of autophagy by an FXR–CREB axis

Lysosomal degradation of cytoplasmic components by autophagy is essential for cellular survival and homeostasis under nutrient-deprived conditions. Acute regulation of autophagy by nutrient-sensing ki...

Cashion Dental Now Providing New Soft Tissue Laser Therapy for Fever Blisters

New Soft-Tissue Laser Therapy for Fever Blisters from Cashion Dental Houston, TX (PRWEB) July 08, 2014 Within the past decade, Cashion Dental has risen to become one of the premier dental practices i...

ZO Skin Health, Inc. Announces Two New Solutions to Address Hyperpigmentation - ZO® Medical C-Bright™ 10% Vitamin C Serum and ZO® Medical Brightalive™ Non-Retinol Skin Brightener

IRVINE, Calif., Aug. 26, 2014 /PRNewswire/ -- ZO Skin Health, Inc. is excited to reveal two new products developed by Zein Obagi, MD to further enhance the ZO® Skin Health Circle™ continuum...

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Keratinocyte-derived laminin-332 promotes melanin synthesis via regulation of tyrosine uptake.

Melanocytes, which produce the pigment melanin, are known to be closely regulated by neighboring keratinocytes. However, how keratinocytes regulate melanin production is unclear. Here, we report that ...

ATG13: Just a companion, or an executor of the autophagic program?

During the past 20 years, autophagy signaling has entered the main stage of the cell biological theater. Autophagy represents an intracellular degradation process that is involved in both the bulk rec...

Evolutionary and biomedical consequences of internal melanins.

The adaptive function of melanin located in the integument is well known. Although pigments are also deposited in various internal organs, their function is unclear. A review of the literature reveale...

Antifungal activity of melanin in clinical isolates of Candida spp.

Background: Melanocytes are cells located in epidermis and mucous membranes that synthesize melanin and cytokines. It is known that melanin has antimicrobial activity and that melanocytes are melanize...

Effective Melanin Depigmentation of Human and Murine Ocular Tissues: An Improved Method for Paraffin and Frozen Sections.

The removal of excessive melanin pigments that obscure ocular tissue morphology is important to address scientific questions and for differential diagnosis of ocular tumours based on histology. Thus, ...

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