Search Results for "Melanin Ulk1"

11:12 EDT 18th April 2015 | BioPortfolio

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The Dark Side of Melanin

Researchers uncover a previously unknown way UV light can act on melanin, spurring cancer-causing mutations hours after sun exposure.

ROS inhibit autophagy by downregulating ULK1 mediated by the phosphorylation of p53 in selenite-treated NB4 cells

Facial Pores in Melanin Layer and Genetic Algorithms for Human Face Characterization

Facial Pores in Melanin Layer and Genetic Algorithms for Human Face CharacterizationPages 12-21Author Carlos Villegas-QuezadaJoan ClimenAbstract The characterization of a face is a vital element for ...

Huntingtin functions as a scaffold for selective macroautophagy

Zhang, Cuervo and colleagues find that Huntingtin (Htt), which is commonly mutated in Huntington disease, regulates selective autophagy. Htt enhances interactions between p62, LC3 and ubiquitylated ca...

Week in Review: February 16?20

Epigenomes galore; one way marijuana affects appetite; anticipating antibiotic resistance; UV exposure, melanin, and harmful mutations

New research unlocks a mystery of albinism

Newly published research provides the first demonstration of how a genetic mutation associated with a common form of albinism leads to the lack of melanin pigments that characterizes the condition.

DNA Damage Continues Long After Sun Exposure

Experiments conducted in mouse and human cells suggest that UV radiation–induced DNA lesions can occur in melanin-producing cells more than 3 hours after sunbathing or tanning (Premi S et al. Scienc...

Global Melanoma Therapeutics Market 2015-2019

About Melanoma According to Melanoma Research Foundation, melanoma is usually, but not always, a cancer of the skin. Melanoma is defined as a cancer that occurs in melanocytes (cells that make the pig...

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Pharmacological Inhibition of ULK1 Blocks mTOR-Dependent Autophagy.

Autophagy is a cell protective and degradative process that recycles damaged and long-lived cellular components. Cancer cells are thought to take advantage of autophagy to help them to cope with the s...

ULK1: A Promising Biomarker in Predicting Poor Prognosis and Therapeutic Response in Human Nasopharygeal Carcinoma.

Plenty of studies have established that dysregulation of autophagy plays an essential role in cancer progression. The autophagy-related proteins have been reported to be closely associated with human ...

Keratinocyte-derived laminin-332 promotes melanin synthesis via regulation of tyrosine uptake.

Melanocytes, which produce the pigment melanin, are known to be closely regulated by neighboring keratinocytes. However, how keratinocytes regulate melanin production is unclear. Here, we report that ...

Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors.

Autophagy is a conserved cellular process that involves the degradation of cellular components for energy maintenance and cytoplasmic quality control that has recently gained interest as a novel targe...

Dopamine-melanin nanofilms for biomimetic structural coloration.

This article describes the formation of dopamine-melanin thin films (50 - 200 nm thick) at an air/dopamine solution interface under static conditions. Beneath these films, spherical melanin granules f...

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