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Relmada Therapeutics Gears Up To Become A Publicly Traded Company

NEW YORK, May 20, 2013 /PRNewswire/ -- Relmada Therapeutics, Inc., a clinical-stage company developing novel therapies for the treatment of chronic pain, today announced that has retained Brio Fi...

The dose-dependent study of verapamil and dilitiazem on spinal anesthesia in the rat.

The aim of this study evaluated the spinal anesthetic effect of verapamil and diltiazem. After rats were injected intrathecally with verapamil and diltiazem, dose-response curves were constructed. We...

Enhanced local anesthetic action of mepivacaine from the bioadhesive gels.

Mepivacaine, an amide-type local anesthetic, has been used to relieve local pain. Among the many drug delivery systems, transdermal drug delivery has some advantages, as it provides controlled drug de...

Dexamethasone added to mepivacaine prolongs the duration of analgesia after supraclavicular brachial plexus blockade.

BACKGROUND AND OBJECTIVES:: Corticosteroids have been used successfully to prolong the duration of local anesthetic action after peripheral nerve and epidural blockade. We hypothesized that the additi...

Local Anesthetics Depolarize Mitochondrial Membrane Potential by Intracellular Alkalization in Rat Dorsal Root Ganglion Neurons.

Background: Although it has been reported that local anesthetics, especially lidocaine, are cytotoxic, the mechanism is unclear. Depolarization of the mitochondrial membrane potential (DeltaPsim), one...

Retinal vascular occlusion after vitrectomy with retrobulbar anesthesia-observational case series and survey of literature.

BACKGROUND: Severe postoperative loss of vision has been occasionally reported as a rare complication of retrobulbar anesthesia, and several possible causes have been proposed in the literature. In th...