Search Results for "Mgmt Immunoexpression Pituitary Adenoma"
Original Source: MGMT immunoexpression in aggressive pituitary adenoma and carcinoma.
Recent case reports have documented the efficacy of temozolomide therapy in some aggressive pituitary adenomas and pituitary carcinomas resistant to multimodality therapy. Evidence suggests that low O6-methylguanine-DNA methyltransferase (MGMT) immunoexpression correlates with response to temozolomide chemotherapy. Herein, we aimed to study MGMT immunoexpression in a spectrum of pituitary tumors, indolent, aggressive and malignant. A literature review of the use of temozolomide in pituitary tumors was also...
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Pituitary gland: New pathways in the pathogenesis of pituitary adenomas
Acromegaly is caused by a growth-hormone-secreting pituitary adenoma. Mutations in the AIP gene predispose patients to young-onset pituitary adenomas that are resistant to somatostatin analogue therap...
CSF Leakage in the Setting of Pituitary Adenomas
Spontaneous CSF rhinorrhea may occur in patients with pituitary adenoma. What clinical factors are most commonly associated with this issue, and how it is best managed? Neurosurgical Focus
Familial Pituitary Adenomas and AIP Mutations
Is genetic testing warranted for family members of patients newly diagnosed with pituitary adenoma? Clinical Endocrinology
What pituitary tumours may tell us about the biology of other cancers
(Medical Xpress) -- Expression levels of a DNA repair gene called MGMT have been widely studied across many cancers as a biomarker of response to temozolomide, a chemotherapeutic agent. Now Australian...
Visual Dysfunction in Nonfunctioning Pituitary Adenomas
New research finds correlations between suprasellar adenoma extension and visual acuity. Clinical Endocrinology
Osteoporosis Linked to Colorectal Adenoma in Women
Osteoporosis is associated with an increased risk of colorectal adenoma in women older than 50 years of age, according...
Changes in pituitary function with ageing and implications for patient care
Multiple subtle changes in hypothalamic–pituitary function occur with ageing. This Review discusses the mechanisms mediating these changes in pituitary function during ageing and the implications fo...
Improved Scope Detects More Colon Polyps (CME/CE)
ORLANDO (MedPage Today) -- The addition of 160° of vision to a colonoscope increased adenoma and polyp detections and lowered adenoma and polyp misses, researchers reported here.
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MGMT immunoexpression in aggressive pituitary adenoma and carcinoma.
Recent case reports have documented the efficacy of temozolomide therapy in some aggressive pituitary adenomas and pituitary carcinomas resistant to multimodality therapy. Evidence suggests that low O...
MGMT promoter methylation and immunoexpression in aggressive pituitary adenomas and carcinomas.
MGMT promoter hypermethylation of aggressive pituitary adenomas and pituitary carcinomas and low protein expression are implicated in improved response to treatment with temozolomide (TMZ). The aim of...
Treatment of pituitary neoplasms with temozolomide: a review.
Temozolomide, an orally administered alkylating agent, is used to treat malignant gliomas. Recent reports also have documented its efficacy in the treatment of pituitary adenomas and carcinomas. Temoz...
MGMT expression in tumors has been correlated with response to treatment with temozolomide therapy. Few medical therapies are available for Nelson syndrome, and the efficacy of such therapeutics remai...
Ghrelin immunoexpression in pituitary adenomas.
Ghrelin, an orexigenic hormone, is normally produced mainly in stomach. In addition, it has been demonstrated in gastric carcinoid tumors and less often in other neuroendocrine tumors. We investigated...
