Search Results for "Mitrochondrial Impairment"
Original Source: Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.
OBJECTIVE: The LRRK2(G2019S) mutation is the most common identifiable cause for Parkinson disease (PD), but the underlying mechanisms leading to neuronal cell death remain largely unclear. Impaired mitochondrial function and morphology have been described in different in vivo and in vitro model systems of early-onset PD (EOPD) as well as in EOPD patient tissue. The aim of our study was to assess mitochondrial function and morphology in LRRK2(G2019S) mutant patient tissue to determine whether impaired mitoch...
Matching Channels
Dementia describes a range of symptoms of cognitive decline. For example memory loss, problems with reasoning and communication skills, and a reduction in a person's abilities and skills in carr...
Phosphodiesterase 4 PDE 4 Inhibitors
Phosphodiesterase 4 (PDE-4) inhibitors have attracted considerable interest as potential therapeutic agents for diseases including chronic obstructive pulmonary disease. PDE-4 inhibitors are known to...
Wernicke encephalopathy is a syndrome characterised by ataxia, ophthalmoplegia, confusion, and impairment of short-term memory. It is caused by lesions in the medial thalamic nuclei, mammillary bodi...
Matching News
Renal impairment in mutiple myeloma
Renal impairment is a common complication in multiple myeloma (MM). It is seen in 20-40% of patients with MM. In about 5% of cases, acute renal impairment occurs, which is oliguric and may require hae...
Neurocognitive Impairment in People with HIV
Neurocognitive impairment- loss of memory, poor concentration and declining mental ability- in people with HIV is most likely to be happening for the same reasons as in the wider population, and the r...
Guidance published on registering a vision impairment as a disability
The department has published information on how to register a vision impairment as a disability. Being registered as partially sighted or blind enables that person to access a range of … Read mo...
Language impairment affects children’s writing ability
Children with specific language impairment have a lower quality of written language than their typically developing peers, show study findings.
Visual impairment and diabetes increase side by side
Visual impairment that is not explained by refractive error is increasing, as is the prevalence of diabetes – particularly diabetes lasting 10 years or longer, show US study results.
Studies describe ability of targeted exercise training on cognitive impairment and dementia
Four studies reported today at the Alzheimer's Association International Conference 2012 (AAIC 2012) describe the ability of targeted exercise training to promote improved mental functioning and reduc...
U.S. visual impairment prevalence increases
Nonrefractive visual impairment in the United States has been found to have increased significantly in recent years, possibly related to an increase in prevalence of diabetes.
Millions suffering from mild cognitive impairment
(Oxford University Press) Three prominent experts from Toronto's Baycrest Institute have published the first book on mild cognitive impairment for the general public.
Matching PubMed Articles
Methamphetamine (METH) abuse is known to be associated with an inordinate rate of infections. Although many studies have described the association of METH exposure and immunosuppression, so far the un...
ABSTRACT: OBJECTIVE: To compare the health-related quality of life (HRQOL) of primary school-age deaf children with or without motor impairment to that of typically developing peers. METHODS: This stu...
Impairment in non-word repetition: a marker for language impairment or reading impairment?
Aim A deficit in non-word repetition (NWR), a measure of short-term phonological memory proposed as a marker for language impairment, is found not only in language impairment but also in reading im...
Two studies were conducted in subjects with mild or moderate hepatic or renal impairment and subjects with normal organ function to evaluate the pharmacokinetics of casopitant and to assess its safety...
Alzheimer's disease and impairment of the Self.
Impairment of the Self has been described in frontal-temporal dementia but little research has been carried out in patients with Alzheimer's disease (AD). OBJECTIVE: The aim of this study was to explo...
