Search Results for "Mouse Pdgf"
Original Source: Tumor cell-derived PDGF-B potentiates mouse mesenchymal stem cells-pericytes transition and recruitment through an interaction with NRP-1.
ABSTRACT: BACKGROUND: New blood vessel formation, or angiogenic switch, is an essential event in the development of solid tumors and their metastatic growth. Tumor blood vessel formation and remodeling is a complex and multi-step processes. The differentiation and recruitment of mural cells including vascular smooth muscle cells and pericytes are essential steps in tumor angiogenesis. However, the role of tumor cells in differentiation and recruitment of mural cells has not yet been fully elucidated. This s...
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The classical tissue factors typically are proteins used for tissue repair and growth stimulation. Among the approved products are the growth factors PDGF, IGF, EGF, BMP and FGF. One of the commercial...
Wnt is an anti-apoptotic ligand for the Fz (frizzled) receptor on cell membranes
Wnt is an anti-apoptotic ligand for the Fz (frizzled) receptor on cell membranes, meaning it attaches to the Fz receptor and prevents cell death (in effect with other cellular stimuli). Wnt molecule...
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Sanofi pharma deals Regeneron for PDGF and ANG2 antibodies
Regeneron pharma deals to acquire full exclusive rights to two families of antibodies invented at the big pharma company’s labs, but previously included in its antibody collaboration with Sanofi. Ac...
PRINCETON, N.J.--(BUSINESS WIRE)--Oct 24, 2012 - Ophthotech Corporation today announced that data from a large, prospective, randomized, controlled Phase 2b clinical trial of Ophthotech's FovistaTM an...
Ophthotech raises $175M for phase III Fovista anti-PDGF combo therapy in wet AMD
Ophthotech, a privately held biopharmaceutical company, has raised $175 million to finance a global phase III clinical program of its lead compound Fovista, an anti-platelet-derived growth factor (PDG...
BioChaperone PDGF-BB: Phase III start
(Medical Xpress)—It is a familiar note struck when authors conclude their reports on experiments conducted in mouse models: They suggest caution when translating their findings from mouse to human....
UIC researchers develop transgenic Alzheimer's mouse with apoE4 gene
Researchers at the University of Illinois at Chicago College of Medicine have developed a transgenic mouse that carries a human gene known to increase risk of Alzheimer's 15-fold. This new mouse mimic...
Hope For Drug Discovery With New, Improved Mouse Model Of Human Alzheimer's Disease
Researchers at the University of Illinois at Chicago College of Medicine have developed a transgenic mouse that carries a human gene known to increase risk of Alzheimer's 15-fold. This new mouse mimic...
Scientists design mouse with more human-like immune response
Scientists have genetically engineered a mouse to more closely mimic a human immune response. The transgenic mouse exhibits humanized CD1d molecules, naturally occurring molecules that activate an esp...
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At the end of the preimplantation period, the inner cell mass (ICM) of the mouse blastocyst is composed of two distinct cell lineages, the pluripotent epiblast (EPI) and the primitive endoderm (PrE)....
The field of tissue engineering is severely limited by the lack of microvascularization in tissue engineered constructs. Biomimetic poly(ethylene glycol) hydrogels containing covalently immobilized pl...
Mitogenic factors promoting intestinal smooth muscle cell proliferation.
Intestinal smooth muscle cells are normally quiescent but in the widely studied model of TNBS-induced colitis in the rat, the onset of inflammation causes proliferation that leads to increased cell nu...
Platelet-derived growth factor (PDGF) is important in central nervous system (CNS) development, and aberrant expression of PDGF and its receptor has been linked to developmental defects and brain tumo...
Several antipsychotics have a high affinity for 5-HT7 receptors yet despite intense interest in the 5-HT7 receptor as a potential drug target to treat psychosis, the function and signaling properties...
