Poly I-Poly C12U

Poly-4-hydroxybutyrate rDNA

poly adenyl ribose polymerase PARP Inhibitors

Poly (ADP-ribose) polymerases (PARPs) are a family of nuclear enzymes implicated in the regulation of multiple physiological cellular functions, including DNA repair, gene transcription, protein modif...

Positive results from Celldex’s CDX-1401 Phase 1 study on solid tumors

Celldex Therapeutics, Inc. today announced positive results demonstrating promising clinical effects in a Phase 1 study of CDX-1401 in solid tumors in combination with the toll-like receptor (TLR) ago...

Stemline sets IPO range

Stemline Therapeutics Inc. (New York, N.Y.) amended its IPO and now plans to sell 3.5 million shares at $11-$13 million. A $12 price would raise $42 million and value the company at $127.9 million. RB...

PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding

Although the poly(A) tail and poly(A) binding protein (PABP) have emerged as important effectors of miRNA function, how they contribute to miRNA-mediated gene silencing has been unclear. A combination...

New report shows educated young adults moving to Pittsburgh region in pursuit of job opportunities

(University of Pittsburgh) Despite Pittsburgh's mass exodus of young people in the 1980s, data released today by the University of Pittsburgh's University Center for Social and Urban Research and Pitt...

Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing

Anthony Bleyer, Eric Lander, Mark Daly and colleagues show that frameshift mutations in a large VNTR of MUC1 cause medullary cystic kidney disease type 1. Their discovery sheds light on the biology of...

Stemline changes IPO range

Stemline Therapeutics Inc. (New York, N.Y.) amended its IPO and now plans to sell 1.8 million shares at $10-$12. An $11 price would raise $20 million and value the company at $59.6 million. Stemline a...

Camera Equipped Polycom VVX Media Phones for End to End Communications Launched by BroadConnect Telecom

Toronto, Ontario (PRWEB) May 07, 2013 BroadConnect Telecom, North America’s premier supplier of hosted voice, video, managed data and security services has announced their intent to deliver un...

Apical MUC1 expression revealed on the foveolar epithelium in H. pylori gastritis

Core-glycosylated Mucin-like Repeats from MUC1 Are an Apical Targeting Signal.

MUC1 is efficiently delivered to the apical surface of polarized Madin-Darby canine kidney (MDCK) cells by transit through apical recycling endosomes, a route associated with delivery of apical protei...

MUC1 immunotherapy is here to stay.

Introduction: Success of HBV vaccines in reducing the incidence of liver cancer, and HPV vaccines in reducing preneoplastic cervical lesions, demonstrate the potential of cancer reduction by harnessin...

MUC1 Protein Expression in Tumor Cells Regulates Transcription of Proinflammatory Cytokines by Forming a Complex with Nuclear Factor-κB p65 and Binding to Cytokine Promoters: IMPORTANCE OF EXTRACELLULAR DOMAIN.

MUC1 is a transmembrane glycoprotein abnormally expressed in all stages of development of human adenocarcinomas. Overexpression and hypoglycosylation of MUC1 in cancer cells compared with normal epith...

Generation of a tumor vaccine candidate based on conjugation of a MUC1 peptide to polyionic papillomavirus virus-like particles.

Virus-like particles (VLPs) are promising vaccine technology due to their safety and ability to elicit strong immune responses. Chimeric VLPs can extend this technology to low immunogenicity foreign a...

Induction of CD8+ T-Cell Responses Against Novel Glioma-Associated Antigen Peptides and Clinical Activity by Vaccinations With {alpha}-Type 1 Polarized Dendritic Cells and Polyinosinic-Polycytidylic Acid Stabilized by Lysine and Carboxymethylcellulose in

PURPOSE A phase I/II trial was performed to evaluate the safety and immunogenicity of a novel vaccination with α-type 1 polarized dendritic cells (αDC1) loaded with synthetic peptides for glioma-ass...