Search Results for "Multicentric Breast Cancer"
Original Source: Multicentric breast cancer: clonality and prognostic studies.
Clonality of multicentric breast cancer has traditionally been difficult to assess. We aimed to assess this using analysis of TP53 status (expression and mutation status). These results were then incorporated into an analysis of prognostic factors in multicentric tumours in a 10-year follow up study. Clonal status of multicentric breast cancer foci (n = 88 foci) was determined by immunohistochemical and molecular studies of TP53 in a total of 40 patients. Prognostic factors from these patients were also c...
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Breast cancer in the UK is diagnosed in nearly 46,000 people each year, with just over 12,000 dying from breast cancer each year in he UK. There are several risk factors for developing b...
Epithelial cell adhesion molecule EpCAM CD326
Epithelial cell adhesion molecule (EpCAM; CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian,...
Selective Estrogen Receptor Modulators SERMs
Selective estrogen receptor modulators (SERMs) act as estrogen receptor (ER) agonists or antagonist depending on the targeted tissue and the specific configuration of the used SERM. Effects on bone, e...
The humanized anti-Her2 monoclonal antibody Herceptin (trastuzumab) has become the mainstay in the treatment of Her2-positive breast cancer. Combining trastuzumab with the potent cytotoxic DM1 via a s...
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Multifocal/multicentric breast cancer connected to a patient's risk of local recurrence
(Fox Chase Cancer Center) Not all women diagnosed with operable breast cancer present with a single tumor; some have multifocal disease appear in the breast, which means multiple tumors found in the s...
Number of tumors found in the breast must be considered for providing radiation therapy
Not all women diagnosed with operable breast cancer present with a single tumor; some have multifocal disease appear in the breast, which means multiple tumors found in the same breast quadrant, while...
Not all women diagnosed with operable breast cancer present with a single tumor; some have multifocal disease appear in the breast—which means multiple tumors all arising from the same primary tumor...
Featured Clinical Trial: Treating KSHV-Associated Multicentric Castleman Disease
The name of the trial is Pilot Study of Tocilizumab in Patients with Symptomatic Kaposi Sarcoma Herpesvirus (KSHV)-Associated Multicentric Castleman Disease (NCI-11-C-0233).
Treating KSHV-Associated Multicentric Castleman Disease
In this pilot study, patients with KSHV-associated multicentric Castleman disease will receive intravenous tocilizumab every other week for up to 12 weeks. Patients who do not benefit from tocilizumab...
Density Of Breasts Does Not Impact Death Among Breast Cancer Patients
A study featured in the August 20 edition in the Journal of the National Cancer Institute reveals that the risk of mortality from breast cancer is not associated with high mammographic breast density...
Treating HER2+ Breast Cancer With HIV Drug
The HIV protease inhibitor, Nelfinavir, can be used to treat HER2-positive breast cancer in the same capacity and dosage regimen that it is used to treat HIV, according to a study published in the Jou...
Breast cancer… do you know who diagnoses you?
Australian women have a 1 in 9 lifetime risk of developing breast cancer and 1 in every 100 breast cancers occurs in men. In 2012, it is estimated that 14,610 women will be diagnosed with breast canc...
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Multicentric breast cancer: clonality and prognostic studies.
Clonality of multicentric breast cancer has traditionally been difficult to assess. We aimed to assess this using analysis of TP53 status (expression and mutation status). These results were then inco...
The aim of this prospective study was to evaluate the efficacy of directives, established to handle additional lesions at preoperative contrast-enhanced magnetic resonance imaging (MRI). Six-hundred-a...
Multicentric castleman disease in a child with primary immunodeficiency.
Multicentric Castleman disease is a rare lymphoproliferative disorder mostly seen in adults with HIV. It presents with fever and systemic symptoms and is extremely uncommon in children. We describe a...
Feasibility of Percutaneous Excision Followed by Ablation for Local Control in Breast Cancer.
PURPOSE: Percutaneous ablation of breast cancer has shown promise as a treatment alternative to open lumpectomy. We hypothesized that percutaneous removal of breast cancer followed by percutaneous abl...
