ACE inhibitors

Phosphodiesterase 4 PDE 4 Inhibitors

Phosphodiesterase 4 (PDE-4) inhibitors have attracted considerable interest as potential therapeutic agents for diseases including chronic obstructive pulmonary disease. PDE-4 inhibitors are known to...

Signal transduction inhibitors

Serotoninnorepinephrine reuptake inhibitors

Purine metabolism inhibitors

Transplantation: Are calcineurin inhibitors safer than mTOR inhibitors?

Isakova et al. report that kidney transplant recipients on mammalian target of rapamycin (mTOR) inhibitors do not have a lower risk of allograft failure but do have a higher risk of death than those...

[Comment] Sofosbuvir: the final nail in the coffin for hepatitis C?

In The Lancet Infectious Diseases, Eric Lawitz and colleagues report results from their randomised phase 2 trial, in which they showed a more than 90% cure rate of hepatitis C in patients given a comb...

New mechanism of action for PARP inhibitors discovered

(American Association for Cancer Research) PARP inhibitors are promising treatments for BRCA-mutant breast and ovarian cancers. Researchers have identified a new way in which these drugs work. New gen...

Intravenous HOE-642 reduces brain edema and Na uptake in the rat permanent middle cerebral artery occlusion model of stroke: evidence for participation of the blood–brain barrier Na/H exchanger

Development of PI3K inhibitors: lessons learned from early clinical trials

Agents targeting the PI3K/AKT/mTOR pathway have been shown to be safe and effective in treating a number of tumour types. This Review outlines the background to these inhibitors and discusses the seco...

[Comment] NS5A inhibitors to treat hepatitis C virus infection

Characterisation of the hepatitis C virus (HCV) life cycle has enabled the development of direct-acting antiviral drugs that target different steps in the viral replication process. So far, many new a...

Scientists discover first selective inhibitors of DAGL enzymes

Scientists at The Scripps Research Institute (TSRI) have discovered the first selective inhibitors of an important set of enzymes. The new inhibitors, and chemical probes based on them, now can be use...

New inhibitors of elusive enzymes promise to be valuable scientific tools

(Scripps Research Institute) Scientists at the Scripps Research Institute have discovered the first selective inhibitors of an important set of enzymes. The new inhibitors, and chemical probes based o...

Na(+)/Ca(2+) Exchanger Inhibitors Inhibit Neurite Outgrowth in PC12 Cells.

To elucidate the role of Na(+)/Ca(2+) exchanger (NCX) in neurite outgrowth, we investigated the effects of NCX inhibitors on neurite outgrowth in PC12 cells. KB-R7943 and 3',4'-dichlorobenzamil, NCX i...

Phosphoinositide 3-kinase-dependent regulation of Na(+)/H (+) exchanger in dendritic cells.

Dendritic cells (DCs), antigen-presenting cells that are able to initiate primary immune responses and to establish immunological memory, are activated by exposure to bacterial lipopolysaccharides (LP...

Na(+)/H(+) exchanger-1: a link with atherogenesis?

Importance of the field: The sodium/hydrogen exchanger-1 (NHE-1/SLC9A1) is a ubiquitous plasma membrane protein whose main role is maintenance of intracellular pH and volume. NHE-1 plays a role in ath...

Is the Multifunctional Na+/H+ Exchanger Isoform 1 a Potential Therapeutic Target in Cancer?

The Na+/H+ exchanger isoform 1 (NHE1) is a ubiquitously expressed transporter fulfilling a variety of cell physiological tasks. By importing Na+ and exporting H+, NHE1 contributes to regulatory volume...

Preferential involvement of Na(+)/Ca(2+) exchanger type-1 in the brain damage caused by transient focal cerebral ischemia in mice.

The Na(+)/Ca(2+) exchanger (NCX), an ion-transporter located in the plasma membrane of neuronal cells, contributes to intracellular Ca(2+) homeostasis. Within the brain, three isoforms (NCX1, NCX2, an...