Search Results for "Nimesulide Dissolution Media In Vitro"
Original Source: Comparison of pharmacokinetics in beagle dogs of nimesulide bilayer tablets with dispersible tablets.
The purpose of this study was to compare the in vitro release and the in vivo pharmacokinetics of bilayer tablets with the conventional dispersible tablets of nimesulide. The tablets were administered to beagle dogs and the plasma levels of nimesulide were determined by high-performance liquid chromatography-MS/MS. The pharmacokinetic parameters were calculated using a noncompartmental model. The bilayer tablets showed a biphasic in vitro release pattern with initial burst release and sustained release foll...
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Type: Original PaperPurposeNanocrystals exhibit enhanced dissolution rates and can effectively increase the bioavailability of poorly water soluble drug substances. However, methods for in vitro chara...
AAPS PharmSciTech: Developing In Vitro–In Vivo Correlation of Risperidone Immediate Release Tablet
Type: Original PaperThe present study was aimed to predict the absorption profile of a risperidone immediate release tablet (IR) and to develop the level A in vitro–in vivo correlation (IVIVC) of th...
Type: Original PaperThe aim of this work was to establish alternative in vitro dissolution method with good discrimination and in vivo predictability for the evaluation of HPMC extended release matrix...
Type: Original PaperThe effect of ternary solid dispersions of poor water-soluble NSAID meloxicam with moringa coagulant (obtained by salt extraction of moringa seeds) and polyvinylpyrrolidone on the...
Dissolution Tests As A Drug Development Tool: Concept Gets FDA Panel Review
The assessment technique has mostly been seen as a confirmatory, not exploratory, process, but FDA will ask its Advisory Committee for Pharmaceutical Science and Clinical Pharmacology to weigh in on r...
Type: Original PaperThe intramuscular administration of the injectable suspension betamethasone sodium phosphate (BSP) and betamethasone dipropionate (BD) has immediate therapeutic activity due to sol...
Agilent Technologies Inc. has introduced LC Dissolution software, an add-on module for use with the ChemStation Edition of the Agilent OpenLAB Chromatography Data System. This software module simplifi...
Type: Original PaperColloidal solid dispersion is an innovative breakthrough in the pharmaceutical industry that overcomes the solubility-related issue of poorly soluble drugs by using an amorphous ap...
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In this work, the influence of imidazolium ionic liquids (ILs) on bio-chemical parameters that influence the in vivo behavior of nimesulide was evaluated. In this context, the binding of nimesulide to...
In this study, a new discriminative dissolution condition for lacidipine tablets was developed by the established in vitro-in vivo relationship. Series of dissolution media of phosphate buffer solutio...
The aim of this study was to investigate the influence of experimental conditions on levothyroxine sodium release from two immediate-release tablet formulations which narrowly passed the standard requ...
Dissolution Testing of Sublingual Tablets: A Novel In Vitro Method.
In the sublingual (SL) cavity, compared with the gastrointestinal tract, tablets are subjected to minimal physiological agitation, and a limited volume of saliva is available to facilitate disintegrat...
In Vitro Dissolution of Oral Modified-Release Tablets and Capsules in Ethanolic Media.
In 2005, Palladone, an extended-release capsule, was withdrawn from the market after clinical testing showed subjects who took the product with alcohol had increased levels of drug in their blood. To...
