Vitamin K

Vitamin K is a group of 2-methilo-naphthoquinone derivatives. There are three notable forms of vitamin K; K1 which can be synthesized by plants, K2 which can be formed by natural bacteria in the int...

Hepatitis B Immune Globulin Nabi

Hepatitis B Immune Globulin (Human), Nabi-HB, is a sterile solution of immunoglobulin (5 1 percent protein) containing antibodies to hepatitis B surface antigen (anti-HBs). It is prepared from plasma...

[Articles] Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study

Hypermethylation of the UTSS region in the TERT promoter is associated with TERT expression in cancers. In paediatric brain tumours, UTSS hypermethylation is associated with tumour progression and poo...

Cytochrome P450–catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis

Thaxtomin phytotoxins produced by plant-pathogenic Streptomyces species contain a nitro group that is essential for phytotoxicity. The N,N′-dimethyldiketopiperazine core of thaxtomins is assembled f...

Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra

The TERT variant rs2736100 is associated with colorectal cancer risk

Novel Derivatives of Docosahexaenoylethanolamide as Therapeutics for Neuronal Disorders

This technology provides derivatives of Docosahexaenoylethanolamide (synaptamide or DEA) which have increased potency and hydrolysis resistance as compared to DEA (structures of these derivatives are...

Promoting telomerase

Two independent teams have identified activating mutations in the promoter of TERT that occur in more than 70% of melanoma cases. The functional role of these mutations still needs further exploration...

Forex, derivatives seen hurting Ranbaxy in Q4 amid atorvastatin woes

Foreign exchange and derivatives issues are expected to dent Ranbaxy’s performance for the fourth quarter ended December 2012, amid concerns pertaining to the recall of certain lots of its gener...

Solvay doubles speciality fluorinated derivatives capacity

Solvay is doubling its production capacity for speciality fluorinated aliphatic derivatives at its Salindres, France plant to meet growing demand in strategic markets, including pharmaceuticals. The G...

Chemoselective nitration of aromatic sulfonamides with tert-butyl nitrite.

A methodology for the efficient conversion of aromatic sulfonamides into their mono-nitro derivatives using tert-butyl nitrite is reported. The reaction exhibits a high degree of chemoselectivity for...

Theoretical and experimental evidence of the photonitration pathway of phenol and 4-chlorophenol: A mechanistic study of environmental significance.

Light-induced nitration pathways of phenols are important processes for the transformation of pesticide-derived secondary pollutants into toxic derivatives in surface waters and for the formation of p...

Unique radical dearomatization and two-electron reduction of a redox-active ligand.

The syntheses and characterizations of [Li(4)][(1,2-di-(tert-butyl)-dpp-BIAN)(2)] (7), (1,2-di-(tert-butyl)-dpp-BIAN) (8), and (1-(tert-butyl)-2-OH-dpp-BIAN) (9) are described. Compound 7 was formed v...

Convenient and mild synthesis of nitroarenes by metal-free nitration of arylboronic acids.

A novel methodology for the direct nitration of arylboronic acids has been developed. By using inexpensive tert-butyl nitrite various aromatic nitro compounds are produced in moderate to good yields (...

Oxidation of synthetic phenolic antioxidants during water chlorination.

The degradation of seven phenolic antioxidants and metabolites during chlorination was investigated. Under strong chlorination conditions (10mgL(-1) chlorine, 24h), five of the target compounds were s...