Notch Pathway Inhibitors DLL4

The Notch signaling pathway has been found to play central roles in humans in stem cell maintenance, cell fate decisions, and in cancer as well. Notch family members are being revealed as oncogenes...

Vascular endothelial growth factor VEGF VEGF R

The importance of tumor angiogenesis in tumor biology is now widely accepted and has emerged as a valid therapeutic target in oncology. Vascular endothelial growth factor (VEGF) represents a key med...

Neoadjuvant therapy

Neoadjuvant therapy is the administration of therapeutic agents before the main treatment. One example is neoadjuvant hormone therapy prior to radical radiotherapy for adenocarcinoma of the prostate...

ACE inhibitors

Phosphodiesterase 4 PDE 4 Inhibitors

Phosphodiesterase 4 (PDE-4) inhibitors have attracted considerable interest as potential therapeutic agents for diseases including chronic obstructive pulmonary disease. PDE-4 inhibitors are known to...

Inhibition of the Notch Signaling Pathway Blocks Lung Cancer Growth in Mouse Model

Spanish researchers have shown that gamma-secretase inhibitors, which block the Notch signaling pathway, effectively stopped the growth of...

Hypoxia, notch signalling, and prostate cancer

In this Review, Marignol and colleagues evaluate the potential involvement of hypoxia in the deregulated expression of notch receptors, ligands, and targets in prostate cancer cells and consider the l...

Dissecting the mechanisms of Notch induced hyperplasia

This genome-wide approach characterizes the repertoire of Notch targets in proliferative growth. Extensive functional categorizations offer significant new insights into regulatory circuits that gover...

Regulation of innate and adaptive immunity by Notch

Notch signalling has well-described roles in lymphocyte development. More recently, it has become apparent that Notch is also crucial for innate immune cells and for mature lymphocyte responses. Here,...

Kinase Inhibitors Could Keep Cancer Patients Alive For Much Longer

Kinase inhibitors, a class of cutting-edge cancer medications, could keep patients alive for far longer than is currently possible after scientists from the University of Sussex and The Institute of C...

Studying The Epigenetics Of Hormone Therapy Resistance Leads To New Drug Target

A team of international cancer researchers led by Dr. Mathieu Lupien at the Princess Margaret Cancer Centre, University Health Network, has identified the signalling pathway that is over-activated in...

Notch control of cell architecture: Potential implications for future cancer therapy

Dissecting the mechanisms implicated in cell architecture should provide new insights for understanding development and tissue morphogenesis in general. An European study focused on the role of the No...

New mechanism of action for PARP inhibitors discovered

(American Association for Cancer Research) PARP inhibitors are promising treatments for BRCA-mutant breast and ovarian cancers. Researchers have identified a new way in which these drugs work. New gen...

One NOTCH Further: Jagged 1 in Bone Metastasis.

The outgrowth of metastatic cells to bone depends on the interaction between multiple intrinsic and host factors. In this issue of Cancer Cell, Sethi and colleagues report Notch signaling in bone cell...

Does notch size predict ACL insertion site size?

PURPOSE: The primary purpose of the current study is to identify a possible correlation between the femoral intercondylar notch size and the ACL insertion site size. The secondary purpose is to determ...

Effects of N-N-(3, 5-difluorophenacetyl-L: -alanyl)-S-phenylglycine t-butyl ester (DAPT) on cell proliferation and apoptosis in Ishikawa endometrial cancer cells.

Endometrial cancer is one of the most common gynecological malignancies in Japan, where the disease shows an increasing morbidity. However, surgical therapy remains the treatment of choice for endomet...

Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells.

Despite evidence supporting an oncogenic role in breast cancer, the Notch pathway's contribution to metastasis remains unknown. Here, we report that the Notch ligand Jagged1 is a clinically and functi...

The involvement of Notch signaling in melanoma vasculogenic mimicry.

Notch signaling plays an important role in tumor angiogenesis. Recent studies suggest that Notch signaling also regulates the progression of primary melanomas toward an aggressive phenotype. The aim o...